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Strategies to improve regenerative potential of mesenchymal stem cells

World Journal of stem cells 2021年第12期13卷 1845-1862页

作者： Mahmood S Choudhery Department of Biomedical Sciences King Edward Medical UniversityLahore 54000PunjabPakistan Department of Genetics and Molecular Biology University of Health SciencesLahore 54600PunjabPakistan

In the last few decades,stem cell-based therapies have gained attention worldwide for various diseases and *** stem cells,particularly mesenchymal stem cells(MSCs),are preferred due to their significant regenerative potential in cellular therapies and are currently involved in hundreds of clinical *** MSCs have high self-renewal as well as differentiation potential,such abilities are compromised with“advanced age”and“disease status”of the ***,cell-based therapies require high cell number for clinical applications that often require in vitro expansion of *** is pertinent to note that aged individuals are the main segment of population for stem cell-based therapies,however;autologous use of stem cells for such patients(aged and diseased)does not seem to give optimal results due to their compromised *** vitro expansion to obtain large numbers of cells also negatively affects the regenerative potential of *** is therefore essential to improve the regenerative potential of stem cells compromised due to“in vitro expansion”,“donor age”and“donor disease status”for their successful autologous *** current review has been organized to address the age and disease depleted function of resident adult stem cells,and the strategies to improve their *** combat the problem of decline in the regenerative potential of cells,this review focuses on the strategies that manipulate the cell environment such as hypoxia,heat shock,caloric restriction and preconditioning with different factors.

关键词： Hypoxia stem cell aging Growth factors Heat shock Caloric restriction

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