检索结果-南通市图书馆

Ankaflavin ameliorates steatotic liver ischemiareperfusion injury in mice

Hepatobiliary & Pancreatic Diseases International 2015年第6期14卷 619-625页

作者： Hao-Jun Yang Li-Ming Tang Xian-Ju Zhou Jun Qian Jie Zhu Ling Lu Xue-Hao Wang liver Transplantation Center First Affiliated Hospital of Nanjing Medical University Department of General Surgery Changzhou No. 2 People's HospitalAffiliated Hospital of Nanjing Medical University Department of Neurology Laboratory of Neurological DiseasesChangzhou No. 2 People's HospitalAffiliated Hospital of Nanjing Medical University

BACKGROUND： It is well-known that steatotic liver is more susceptible to ischemia-reperfusion （I/R） injury during liver transplantation, liver resection and other liver surgeries. The increasing incidence of non-alcoholic fatty liver disease （NAFLD） decreases the availability of liver donors. Although steatotic liver is now accepted as a source of liver for trans- plantation, NAFLD exacerbates the liver injury after liver surgery. The present study was to investigate the protective role of ankaflavin in steatotic liver I/R injury.

关键词： ankaflavin ischemia-reperfusion Kupffer cells steatotic liver

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Trimetazidine:Is it a promising drug for use in steatotic grafts?

引用

World Journal of Gastroenterology 2006年第6期12卷 908-914页

作者： IsmailBenMosbah AraníCasillas-Ramírez CarmeXaus AnnaSerafín JoanRoselló-Catafau CarmenPeralta Department of Experimental Pathology Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas Instituto de Investigaciones Biomédicas de Barcelona August Pii SunyerBarcelonaSpain

AIM： Chronic organ-donor shortage has led to the acceptance of steatotic livers for transplantation, despite the higher risk of graft dysfunction or nonfunction associated with the ischemic preservation period of these organs. The present study evaluates the effects of trimetazidine （TMZ） on an isolated perfused liver model. METHODS： steatotic and non-steatotic livers were preserved for 24 h in the University of Wisconsin （UW） solution with or without TMZ. Hepatic injury and function （transaminases, bile production and sulfobromophthalein （BSP） clearance） and factors potentially involved in the susceptibility of steatotic livers to ischemia-reperfusion （I/R） injury, including oxidative stress, mitochondrial damage, microcirculatory diseases, and ATP depletion were evaluated. RESULTS： steatotic livers preserved in UW solution showed higher transaminase levels, lower bile production and BSP clearance compared with non-steatotic livers. Alterations in perfusion flow rate and vascular resistance, mitochondrial damage, and reduced ATP content were more evident in steatotic livers. TMZ addition to UW solution reduced hepatic injury and ameliorated hepatic functionality in both types of the liver and protected against the mechanisms potentially responsible for the poor tolerance of steatotic livers to I/R. CONCLUSION： TMZ may constitute a useful approach in fatty liver surgery, limiting the inherent risk of steatotic liver failure following transplantation.

关键词： steatotic liver Ischemia-reperfusion UW preservation solution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：