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Stepping up to meet the challenge of freezing of gait in Parkinson’s disease

Translational Neurodegeneration 2022年第1期11卷 589-600页

作者： Simon Lewis Stewart Factor Nir Giladi Alice Nieuwboer John Nutt Mark Hallett ForeFront Parkinson’s Disease Research Clinic Brain and Mind CentreSchool of Medical SciencesUniversity of SydneySydneyNSWAustralia Jean and Paul Amos Parkinson’s Disease and Movement Disorders Program Emory University School of MedicineAtlantaGAUSA Movement Disorders Unit Department of NeurologyTel-Aviv Sourasky Medical CenterSackler School of Medicine and Sagol School of NeuroscienceTel Aviv UniversityTel AvivIsrael Department of Rehabilitation Sciences KU LeuvenLeuvenBelgium Movement Disorder Section Department of NeurologyOregon Health&Science UniversityPortlandORUSA Human Motor Control Section National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaMDUSA.

There has been a growing appreciation for freezing of gait as a disabling symptom that causes a significant burden in Parkinson’s disease. Previous research has highlighted some of the key components that underlie the phenomenon, but these reductionist approaches have yet to lead to a paradigm shift resulting in the development of novel treatment strategies. Addressing this issue will require greater integration of multi-modal data with complex computational modeling, but there are a number of critical aspects that need to be considered before embarking on such an approach. This paper highlights where the field needs to address current gaps and shortcomings including the standardization of definitions and measurement, phenomenology and pathophysiology, as well as considering what available data exist and how future studies should be constructed to achieve the greatest potential to better understand and treat this devastating symptom.

关键词： Freezing of gait Computational modeling standardized definitions and assessments Novel paradigms Phenomenology Pathophysiology Treatment

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