检索结果-南通市图书馆

Telencephalic stab wound injury induces regenerative angiogenesis and neurogenesis in zebrafish:unveiling the role of vascular endothelial growth factor signaling and microglia

引用

Neural Regeneration Research 2025年第10期20卷 2938-2954页

作者： Danielle Fernezelian Philippe Rondeau Laura Gence Nicolas Diotel Universitéde La Réunion INSERMUMR 1188Diabète athérothrombose Thérapies Réunion Océan Indien(DéTROI)Saint PierreLa RéunionFrance

After brain damage,regenerative angiogenesis and neurogenesis have been shown to occur simultaneously in mammals,suggesting a close link between these ***,the mechanisms by which these processes interact are not well *** this work,we aimed to study the correlation between angiogenesis and neurogenesis after a telencephalic stab wound *** this end,we used zebrafish as a relevant model of neuroplasticity and brain repair ***,using the Tg(fli1:EGFP×mpeg1.1:mCherry)zebrafish line,which enables visualization of blood vessels and microglia respectively,we analyzed regenerative angiogenesis from 1 to 21 days *** parallel,we monitored brain cell proliferation in neurogenic niches localized in the ventricular zone by using *** found that after brain damage,the blood vessel area and width as well as expression of the fli1 transgene and vascular endothelial growth factor(vegfaa and vegfbb)were *** the same time,neural stem cell proliferation was also increased,peaking between 3 and 5 days post-lesion in a manner similar to angiogenesis,along with the recruitment of ***,through pharmacological manipulation by injecting an anti-angiogenic drug(Tivozanib)or Vegf at the lesion site,we demonstrated that blocking or activating Vegf signaling modulated both angiogenic and neurogenic processes,as well as microglial ***,we showed that inhibition of microglia by clodronate-containing liposome injection or dexamethasone treatment impairs regenerative neurogenesis,as previously described,as well as injury-induced *** conclusion,we have described regenerative angiogenesis in zebrafish for the first time and have highlighted the role of inflammation in this *** addition,we have shown that both angiogenesis and neurogenesis are involved in brain repair and that microglia and inflammation-dependent mechanisms activated by Vegf signaling are important contributors to

关键词： angiogenesis cerebral damage inflammation neurogenesis stab wound telencephalon vascular endothelial growth factor zebrafish

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aortoduodenal fistula following aortic reconstruction of a pseudoaneurysm caused by stab wound 12 years ago

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第5期10卷 400-403页

作者： Jian-cang ZHOU＊ Qiu-ping XU Lai-gen SHEN Kong-han PAN Yi-ping MOU Department of Critical Care Medicine Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Gastrointestinal bleeding due to aortoenteric fistula is extremely *** fistula is difficult to be diagnosed timely and entails a significant morbidity and ***,we present an uncommon case of gastrointestinal bleeding caused by aortoduodenal fistula,which was a complication of a successful aortic reconstruction 4 months ago for an aortic pseudoaneurysm resulted from a stab wound 12 years *** urgent laparotomy confirmed an aortoduodenal fistula and repaired the defects in aorta and duodenum,but a prolonged shock led to the patient's *** summary,early diagnosis and surgical intervention for aortoenteric fistula are vital for survival.

关键词： Aortoduodenal fistula Aortic pseudoaneurysm Aortic reconstruction stab wound

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of follow-up and long-term outcomes of gunshot and stab wounds in a French civilian population

引用

Chinese Journal of Traumatology 2022年第4期25卷 201-208页

作者： Julie Fournier Laure Salou-Regis Ghislain Pauleau Geraldine Goin Bruno de La Villeon Yvain Goudard Emergency Department Laveran Military HospitalBoulevard Laveran13013MarseilleFrance Visceral and Digestive Surgery Unit Laveran Military HospitalBoulevard Laveran13013MarseilleFrance

Purpose The data concerning long-term follow-up and outcomes of penetrating trauma are poorly detailed in the *** main objective of our study was to analyze the hospital and extra-hospital follow-up of penetrating trauma victims and to evaluate the late complications and long-term consequences of these *** This work was a retrospective longitudinal monocentric observational study conducted at Laveran Military Hospital,from January 2007 to January *** patients hospitalized for gunshot wound or stab wound management during this period were identified via a retrospective systematic query in the hospital information system using the ICD-10 *** data,traumatism characteristics,hospital management,follow-up and traumatism consequences(i.e.,persistent disability)were *** improve evaluation of traumatism long-term consequences,extra-hospital follow-up data from general physicians(GP)were collected by phone *** this interview,9 closed questions were asked to the *** survey evaluated:the date of the last consultation related to injury with the GP,the specific follow-up carried out by the GP,traumatism consequences,and recurrence of ***,univariate and multivariate with regression analysis were used for statistical *** A total number of 165 patients were ***(Q1,Q3)of hospital follow-up was 28(4,66)*** hundred one patients(61.2%)went to their one-month consultation at *** follow-up was achieved for 76 patients(55.2%).Median(Q1,Q3)of GP follow-up was 47(21,75)***-four patients(14.5%)have been totally lost to follow *** overall follow-up identified 54 patients(32.7%)with long-term consequences,20 being psychiatric disorders and 30 organic *** consequences were mainly peripheral nerve damages(n=20;12.1%).Most of the psychiatric consequences were diagnosed during GP follow-up(n=14;70%).Seventeen cases(10.3%)of recurrence were found and la

关键词： stab wound Gunshot wound Injury Consequences Follow-up Outcomes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：