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Promotional effects of exogenous stimulation with pulsed electromagnetic fields on skin wound healing in diabetic rats

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Journal of Hainan Medical University 2019年第5期25卷 1-5页

作者： Yan Han Ze-Dong Yan Shu-Hua Ge Respiratory Intensive Care Unit Xijing Hospital of Air Force Military Medical University710032Xi'anChina Department of Military Biomedical Engineering of Air Force Military Medical University 710032Xi'anChina

Objective:The current study aims to identify the effects of exogenous application of pulsed electromagnetic fields on skin wound healing in diabetic rats, and thus provides experimental evidence for its more scientific clinical application in the ***: The diabetic animal models were established via intraperitoneal injection of streptozotocin in 4-month-old male rats. Fourth eight rats were randomly assigned into the diabetes group (DM) and diabetes coupled with pulsed electromagnetic fields (DM+PEMF) group. Another 24 normal rats were used as the blank control group (Control). Then, all the rats in the three groups were subjected to dorsal surgery for the establishment of soft tissue wound model (circular wound with the diameter of 2 cm). Then, the rats in the DM+PEMF group were subjected to pulsed electromagnetic fields stimulation. Then, 6 rats in each group were sacrificed at Day 5, 12 and 19 post surgery. The glucose levels, wound closure, wound healing time and tissue tensile strength were examined and ***: Pulsed electromagnetic fields significantly increased the wound closure rate in diabetic rats at Day 5, 12 and 19 post surgery, decreased overall wound healing period in diabetic rats, and also enhanced tissue tensile strength in diabetic rats at Day 5, 12 and 19 post ***: Low-intensity pulsed electromagnetic fields can significantly accelerate diabetic wound healing process, and also improve diabetic tissue repair capacity. This study may be helpful for providing more scientific and reasonable experimental evidence for the treatment of pulsed electromagnetic fields on diabetic wound healing in clinics.

关键词： Pulsed electromagnetic fields Diabetes sskin wound Tissue tensile strength Glucose

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