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A hippocampal anti-hypertensive mechanism induced by twirling reinforcing-reducing manipulation in rats

Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 106-117页

作者： Jiao Sun Liu Yan Yunhong Zhu Jingrong Liang Yingying Zang Tianxiao Zeng Xiaomin Hao Pui Yee Wong Qingguo Liu School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 102488China Department of Rehabilitation Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser Hospital)Qingdao 266033China Department of Acupuncture Mediseed Chinese Medicine Consulting CentrePetaling Jaya 46200Malaysia

Objective:To investigate a hippocampal anti-hypertensive mechanism induced by twirling reinforcingreducing manipulation(TRRM)using proteomics in ***:Forty-two male spontaneously hypertensive rats were randomly divided into 3 groups,and 14 Wistar-Kyoto rats were served as control *** the twirling reinforcing(TRF)group,needles were directly inserted into the Taichong(LR 3)point,then thumbs were moved heavily forward and lightly backward for 3 min,while needles remained inserted for 17 *** the twirling reduction(TRD)group,the same treatment was applied as in the TRF group except that the thumb moved lightly forward and heavily *** the model and control groups,only the corresponding grasping and fixation were *** interventions were conducted for 14 *** blood pressure(BP)of all rats was measured one day before intervention and every other day *** hematoxylin-eosin(H&E)staining,label-free and parallel reaction monitoring proteomic techniques were used to assess hippocampal samples from each ***:Systolic BPs showed a significant decrease in the TRF and TRD groups compared with the model group(P<.01).In the model group,H&E staining showed obvious pathological changes in the hippocampus,while in the TRF and TRD groups,the hippocampal morphology was only slightly *** proteomic analysis revealed 1163 differential protein expressions between *** Ontology enrichment analysis confirmed that the differentially expressed proteins were enriched in different biological processes,cellular components,and molecular *** Encyclopedia of Genes and Genomes enrichment analysis showed that TRRM proteins were expressed in the serotonergic synapse pathway,renin-angiotensin system,the mitogen-activated protein kinase signaling pathway,and the peroxisome pathway,which were all also related to BP ***:TRRM can significantly lower the BP of *** mode of action may be through the activation

关键词： Twirling reinforcing-reducing method Blood pressure hypertension Hippocampus Proteomics spontaneously hypertension rats Taichong Acupuncture

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