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High spindle and kinetochore-associated complex subunit-3 expression predicts poor prognosis and correlates with adverse immune infiltration in hepatocellular carcinoma

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世界胃肠外科杂志:英文版(电子版) 2023年第8期15卷 1600-1614页

作者： Lin-Lin Zheng Ya-Ru Wang Zhen-Rong Liu Zhi-Hao Wang Chang-Cheng Tao Yong-Gang Xiao Kai Zhang An-Ke Wu Hai-Yang Li Jian-Xiong Wu Ting Xiao Wei-Qi Rong Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology Department of Etiology and CarcinogenesisNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Hepatobiliary Hernia Surgery Liaocheng Dongcangfu People's HospitalLiaocheng 252000Shandong ProvinceChina The Second Ward of Hepatobiliary Surgery Qianxinan People's HospitalXingyi 562400Guizhou ProvinceChina Department of Interventional Therapy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin's Clinical Research Center for CancerTianjin 300000China

BACKGROUND spindle and kinetochore-associated complex subunit 3(SKA3)is a malignancyassociated gene that plays a critical role in the regulation of chromosome separation and cell ***,the molecular mechanism through which SKA3 regulates tumor cell proliferation in hepatocellular carcinoma(HCC)has not been fully *** To investigate the molecular mechanisms underlying the role of SKA3 in *** SKA3 expression,clinicopathological,and survival analyses were performed using multiple public database platforms,and the results were verified by Western blot and immunohistochemistry staining using collected clinical *** enrichment analyses were performed to evaluate the biological functions and molecular mechanisms of SKA3 in ***,the Tumor Immune Estimation Resource and single-sample Gene Set Enrichment Analysis(ssGSEA)algorithms were utilized to investigate the abundance of tumor-infiltrating immune cells in *** response to chemotherapeutic drugs was evaluated by the R package“pRRophetic”.RESULTS We found that upregulated SKA3 expression was significantly correlated with poor prognosis in patients with *** Cox regression analysis indicated that SKA3 was an independent risk factor for *** revealed that SKA3 expression may facilitate proliferation and migratory processes by regulating the cell cycle and DNA ***,patients with high SKA3 expression had significantly decreased ratios of CD8+T cells,natural killer cells,and dendritic *** sensitivity analysis showed that the high SKA3 group was more sensitive to sorafenib,sunitinib,paclitaxel,doxorubicin,gemcitabine,and *** High SKA3 expression led to poor prognosis in patients with HCC by enhancing HCC proliferation and repressing immune cell infiltration surrounding ***3 may be used as a biomarker for poor prognosis and as a therapeutic target in HCC.

关键词： spindle and kinetochore-associated protein 3 Hepatocellular carcinoma Prognosis Immune infiltration cells

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