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Determination of sparfloxacin in Human Urine by Reversed-Phase High Performance Liquid Chromatography With Nitrous Acid and Hydroiodic Pre-Column Derivatization

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Chinese Chemical Letters 2001年第11期12卷 1007-1010页

作者： Li Ming DU Zhe Feng FAN Jin Li QIAO Jing Ping WANG Analysis and Test Center Shanxi Teachers UniversityLingfen 041004 Department of Chemistry Arts and Sciences CollegeTaiyuan University of TechnologyTaiyuan 030006

sparfloxacin can be oxidized by nitrous acid, then react with hydroiodic acid to form a fluorescent derivative. Based on this, a reversed-phase high performance liquid chromatographic pre-column derivatization new method is described for the determination of sparfloxacin in human urine. The linear range is 0.05 mg/L to 4.0 mg/L, the recoveries are 91.5%similar to 95.7% and the RSD is 1.2%similar to4.2%. The results showed that this method is suitable for the determination of sparfloxacin in human urine.

关键词： sparfloxacin HPLC pre-column derivatization human urine

Study on Fluorescence Property of sparfloxacin Derivatizing System and its Application

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Chinese Chemical Letters 2000年第3期11卷 255-258页

作者： Du, LM Zhou, J Xu, QQ Fan, ZF Yuan, R Shanxi Normal Univ Ctr Anal & Test Linfen 041004 Peoples R China

In acid medium, sparfloxacin is oxidized by nitrous acid, then reacts with hydrobromic acid to form a new fluorescence substance, which can emit the strong fluorescence. which is 151 fold more than that of sparfloxacin itself. By this, a new sensitive method for the determination of sparfloxacin in human urine by derivative-synchronous fluorescence is presented with good results.

关键词： sparfloxacin nitrous acid derivative-synchronous fluorescence human urine

Simple and sensitive determination of sparfloxacin in pharmaceuticals and biological samples by immunoassay

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Journal of Pharmaceutical Analysis 2012年第3期2卷 214-219页

作者： Hua-Jin Zenga,Ran Yangb,Bing Liub,Li-Fang Leib,Jian-Jun Lib,Ling-Bo Qub,c,n aSchool of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China bDepartment of Chemistry,Zhengzhou University,Zhengzhou 450001,China cSchool of Chemistry & Chemical Engineering,Henan University of Technology,Zhengzhou 450001,China School of Pharmaceutical Sciences Zhengzhou University Zhengzhou 450001 China. Department of Chemistry Zhengzhou University Zhengzhou 450001 China. School of Chemistry & Chemical Engineering Henan University of Technology Zhengzhou 450001 China.

Plasma quinolone concentrations are not routinely measured in clinical ***,in order to optimize quinolone treatment,monitoring of plasma concentrations could sometimes be useful particularly in critically ill *** this study,anti-sparfloxacin antibody was obtained by immunizing rabbits with sparfloxacin conjugated with bovine serum albumin using isobutyl chloroformate *** the assay procedure was optimized,the standard curve of sparfloxacin was *** practical measuring range of the competitive ELISA extended from 5 ng/mL to 2 mg/*** recovery rates and coefficients of variation for rat plasma,urine and tissues were 87.7-106.2% and 4.8-15.3%,*** demonstrate the potential of the ELISA,a preliminary pharmacokinetics and tissue distribution study of sparfloxacin in rats and quantitative analysis of sparfloxacin in several pharmaceuticals were performed and compared with high-performance liquid chromatography(HPLC).The experimental data indicated that the proposed method would be a valuable tool in therapeutic drug monitoring(TDM) for sparfloxacin.

关键词： sparfloxacin Enzyme-linked immunosorbent assay(ELISA) Biological samples Pharmacokinetics Tissue distribution

sparfloxacin对接种于裸鼠足垫的麻风分枝杆菌的抗菌活性

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地方病译丛 1993年第3期14卷 52-54页

作者： M. Gidoh 郭其杰

目前,大多数人相信用DDS,B663和RFP联合化疗治疗麻风病是可靠的。但是,麻风菌对这些药的每一种都有耐药的报道,DDS是抑制剂,B663有不利的副作用,即皮肤色素沉着。RFP是可靠的杀菌药物,但是价格太贵。因此,需要发展新的,与现有的抗麻风... 详细信息

目前,大多数人相信用DDS,B663和RFP联合化疗治疗麻风病是可靠的。但是,麻风菌对这些药的每一种都有耐药的报道,DDS是抑制剂,B663有不利的副作用,即皮肤色素沉着。RFP是可靠的杀菌药物,但是价格太贵。因此,需要发展新的,与现有的抗麻风药无交叉耐药、有杀菌作用、毒性小和比RFP价格低的抗麻风药。

关键词： sparfloxacin 麻风杆菌抗菌活性

sparfloxacin抗裸鼠足垫内麻风菌的活性

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International Journal of Dermatology And Venereology 1993年第3期 190-191页

作者：沈建平

sparfloxacin(SPFX)是一种新喹诺酮类药.作者以前发现该药在裸鼠实验化疗中的抗麻风菌活性比氟嗪酸强。据此,作者对该药的抗麻风活性作了更详细的研究.实验化疗采用动力法。在第一个实验中,以 SPFX2.5和10mg/kg 剂量,每周5或6次连续管饲... 详细信息

sparfloxacin(SPFX)是一种新喹诺酮类药.作者以前发现该药在裸鼠实验化疗中的抗麻风菌活性比氟嗪酸强。据此,作者对该药的抗麻风活性作了更详细的研究.实验化疗采用动力法。在第一个实验中,以 SPFX2.5和10mg/kg 剂量,每周5或6次连续管饲,在接种后60～152天给药。第二个实验中为间歇给药,剂量为10和20mg/kg 每周2次或30mg/kg 每周1次管饲,均在接种后61～154天给药。实验动物为5周龄的 BALB/C 雌性裸鼠,随机分组,每组10

关键词：麻风菌 sparfloxacin 麻风杆菌裸鼠足垫

sparfloxacin在小鼠体内比氟嗪酸杀麻风菌的活性更强

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地方病译丛 1994年第3期15卷 60-61页

作者： Scot.,GF 韩法举

New Method for Optimization and Simultaneous Determination of sparfloxacin and Non Steroidal Anti-Inflammatory Drugs: Its <i>In-Vitro</i>Application

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American Journal of Analytical Chemistry 2012年第4期3卷 328-337页

作者： Somia Gul Najma Sultana Muhammad Saeed Arayne Sana Shamim Mahwish Akhtar College of Pharmacy Dow University of Health Sciences Karachi Pakistan Faculty of Pharmacy Jinnah University for Women Karachi Pakistan United Biotech (Pvt) Ltd. Karachi Pakistan

A simple reversed phase HPLC method was developed and validated for the simultaneous determination of sparfloxacin (SPFX), diclofenac sodium, meloxicam, ibuprofen, flurbiprofen, naproxen and mefenemic acid in a relatively short time with high linearity in bulk material, pharmaceutical formulations and human serum. Purospher STAR C18 (250 × 4.6 mm, 5 μm) column was utilized with mobile phase, methanol and water (90:10, v/v pH 2.70 adjusted by phosphoric acid), was delivered at a flow rate of 1.5 ***–1. Eluent was monitored using UV detector at 240 nm. The proposed method is specific, accurate (98.42% - 102.75%), precise (intra-day and inter-day variation 0.011% - 1.85%) and linear (R2 > 0.999) with in the desired range 0.15 - 40 μ***–1 and the detection and quantification limit was 1.19E+08 – 0.150 μ***–1 and 3.62E+08 – 0.4574 μ***–1 respectively for SPFX and NSAIDs. The analysis of variance (ANOVA) and student’s t-test were applied to verify the results. The anticipated method is applicable to routine analysis of SPFX and NSAIDs in pharmaceutical formulations as well as in human serum samples. It has also applied on interaction of SPFX with NSAIDs.

关键词： sparfloxacin NSAIDs HPLC Interactions ANOVA

新喹诺酮sparfloxacin对哮喘病人体内茶碱药代动力学的影响

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国外医药(抗生素分册) 1992年第5期 397-398页

作者：陈和顺

茶碱广泛用于治疗气道可逆阻塞疾病的患者。然而,在治疗哮喘病方面茶碱,通常与各种其它药物联用。茶碱与其它药物的相互作用已有大量报道。当某些喹诺酮抗菌药物与茶碱联用时,由于茶碱的排泄受到抑制,增加了副作用,可能影响治疗。由于... 详细信息

茶碱广泛用于治疗气道可逆阻塞疾病的患者。然而,在治疗哮喘病方面茶碱,通常与各种其它药物联用。茶碱与其它药物的相互作用已有大量报道。当某些喹诺酮抗菌药物与茶碱联用时,由于茶碱的排泄受到抑制,增加了副作用,可能影响治疗。由于喹诺酮一般被认为是茶碱代谢的抑制剂,引起茶碱血浆清除率的减小。然而,茶碱和喹诺酮相互作用的确切机理还不十分清楚。因此,测定茶碱和喹诺酮相互作用的药代动力学仍然是一个感兴趣的课题。过去几年,具有广谱抗菌活性的大量新喹诺酮抗菌药物,已经得到发展。Sparflo

关键词：哮喘病人茶碱药代动力学 sparfloxacin

新喹诺酮类合成抗菌剂sparfloxacin

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国外医药（合成药．生化药．制剂分册） 1992年第5期13卷 285-289页

作者：许铁男东北第六制药厂

斯帕沙星(sparfloxacin)为广谱的新喹诺酮类合成抗菌剂,对包括肺炎球菌、甲氧西林耐药性金黄色葡萄球菌的革兰阳性菌、包括绿脓杆菌、沙雷菌、包括葡萄糖非发酵菌的革兰阴性菌、厌氧菌、军团菌、支原体、衣原体、结核菌、非定型抗酸菌... 详细信息

斯帕沙星(sparfloxacin)为广谱的新喹诺酮类合成抗菌剂,对包括肺炎球菌、甲氧西林耐药性金黄色葡萄球菌的革兰阳性菌、包括绿脓杆菌、沙雷菌、包括葡萄糖非发酵菌的革兰阴性菌、厌氧菌、军团菌、支原体、衣原体、结核菌、非定型抗酸菌等均显示出广泛的抗菌活性,其抗菌效力在新喹诺酮类中属最强者。

关键词：喹诺酮类抗菌剂 sparfloxacin