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Recent advances in nanomaterials for sonodynamic therapy

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Nano Research 2020年第11期13卷 2898-2908页

作者： Ting Xu Shaojing Zhao Changwei Lin Xiuli Zheng Minhuan Lan Hunan Provincial Key Laboratory of Micro&Nano Materials Interface Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha410083China Department of Gastrointestinal surgery The Third Xiang Ya Hospital of Central South UniversityChangsha410013China Key Laboratory of Photochemical Conversion and Optoelectronic Materials and City U-CAS Joint Laboratory of Functional Materials and Devices Technical Institute of Physics and Chemistry(TIPC)Chinese Academy of SciencesBeijing100190China

Sonodynamic therapy(SDT),as a novel non-invasive strategy for eliminating tumor,has the advantages of deeper tissue penetration,fewer side effects,and better patient compliance,compared with photodynamic therapy(PDT).In SDT,ultrasound was used to activate sonosensitizer to produce cytotoxic reactive oxygen species(ROS),induce the collapse of vacuoles in solution,and bring about irreversible damage to cancer *** recent years,much effort has been devoted to developing highly efficient sonosensitizers which can efficiently generate ***,the traditional organic sonosensitizers,such as porphyrins,hypericin,and curcumins,suffer from complex synthesis,poor water solubility,and low tumor targeting efficacy which limit the benefits of *** contrast,inorganic sonosensitizers show good in vivo stability,controllable physicochemical properties,ease of achieving multifunctionality,and high tumor targeting,which greatly expanded their application in *** this review,we systematically summarize the nanomaterials which act as the carrier of molecular sonosensitizers,and directly produce ROS under ***,the prospects of inorganic nanomaterials for SDT application are also discussed.

关键词： sonodynamic therapy sonosensitizers reactive oxygen species carriers nanomaterial

Modulation of reactive oxygen species to enhance sonodynamic therapy

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Particuology 2023年第4期75卷 199-216页

作者： Xiaoyu Liu Xueting Pan Chaohui Wang Huiyu Liu Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic CompositesBeijing Laboratory of Biomedical MaterialsBionanomaterials&Translational Engineering LaboratoryBeijing Key Laboratory of BioprocessBeijing University of Chemical TechnologyBeijing100029China

Reactive oxygen species(ROS),involving in many biological reactions,play an important role in disease *** the various ROS-based therapeutic modalities,sonodynamic therapy(SDT)stands out with its unique *** turn,the SDT efficacy is mainly dependent on the ROS levels in the disease ***,in recent years,researchers have extensively investigated SDT with high ROS generation *** this review,we focus on effective strategies to improve the therapeutic ef-ficiency of SDT by modulating ROS,overview the basic mechanisms of ROS generation by sonosensitizers,highlight the rational design of sonosensitizers,and summarize strategies to improve the SDT efficacy by modulating disease *** addition,multiple ROS synergistic treatment modalities and the prospect of SDT are *** believe that the understanding and exploration of SDT enhancement strategies will facilitate the clinical translation of SDT.

关键词： Reactive oxygen species Sonodynamic therapy sonosensitizers Oxidative stress Combination therapy

Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives

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Military Medical Research 2023年第1期10卷 94-112页

作者： Qing-Long Guo Xing-Liang Dai Meng-Yuan Yin Hong-Wei Cheng Hai-Sheng Qian Hua Wang Dao-Ming Zhu Xian-Wen Wang School of Biomedical Engineering Research and Engineering Center of Biomedical MaterialsAnhui Medical UniversityHefei 230032China Department of Neurosurgery the First Affiliated Hospital of Anhui Medical UniversityHefei 230032China Department of Oncology the First Affiliated Hospital of Anhui Medical UniversityHefei 230032China Department of General Surgery and Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor Nanfang Hospitalthe First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510515China

Glioblastoma multiforme(GBM) is the most common primary malignant brain tumor, and it is associated with poor prognosis. Its characteristics of being highly invasive and undergoing heterogeneous genetic mutation, as well as the presence of the blood–brain barrier(BBB), have reduced the efficacy of GBM treatment. The emergence of a novel therapeutic method, namely, sonodynamic therapy(SDT), provides a promising strategy for eradicating tumors via activated sonosensitizers coupled with low-intensity ultrasound. SDT can provide tumor killing effects for deep-seated tumors, such as brain tumors. However, conventional sonosensitizers cannot effectively reach the tumor region and kill additional tumor cells, especially brain tumor cells. Efforts should be made to develop a method to help therapeutic agents pass through the BBB and accumulate in brain tumors. With the development of novel multifunctional nanosensitizers and newly emerging combination strategies, the killing ability and selectivity of SDT have greatly improved and are accompanied with fewer side effects. In this review, we systematically summarize the findings of previous studies on SDT for GBM, with a focus on recent developments and promising directions for future research.

关键词： Glioblastoma multiforme(GBM) Blood–brain barrier(BBB) Sonodynamic therapy(SDT) sonosensitizers Combination therapy

Titanium carbide nanosheets with defect structure for photothermal-enhanced sonodynamic therapy

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Bioactive Materials 2022年第2期7卷 409-419页

作者： Guangqiang Li Xiaoyan Zhong Xianwen Wang Fei Gong Huali Lei Yangkai Zhou Chengfei Li Zhidong Xiao Guoxi Ren Liang Zhang Zhiqiang Dong Zhuang Liu Liang Cheng College of Science State Key Laboratory of Agricultural MicrobiologyHuazhong Agricultural UniversityWuhan430070China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China Department of Toxicology School of Public HealthMedical College of Soochow UniversitySuzhou215123China State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai200050China College of Biomedicine and Health College of Life Science and TechnologyHuazhong Agricultural UniversityWuhanHubei430070China

Sonodynamic therapy(SDT)has attracted widespread interest in biomedicine,owing to its novel and noninvasive therapeutic method triggered by ultrasound(US).Herein,the Ti_(3)C_(2) MXene nanosheets(Ti_(3)C_(2) NSs)are developed as good sonosensitizers via a two-step method of chemical exfoliation and high-temperature *** the high-temperature treatment,the oxygen defect of Ti_(3)C_(2) MXene nanosheets(H-Ti_(3)C_(2) NSs)is greatly ***,the electron(e^(-))and hole(h^(+))generated by US can be separated faster due to the improved degree of oxidation,and then the recombination of e^(-)-h^(+)can be prevented with the abundant oxygen defect under US irradiation,which induced the sonodynamic efficiency greatly to improve around 3.7-fold compared with Ti_(3)C_(2) NSs without high-temperature *** PEGylation,the H-Ti_(3)C_(2)-PEG NSs show good stability and *** vitro studies exhibit that the inherent property of mild photothermal effect can promote the endocytosis of H-Ti_(3)C_(2)-PEG NSs,which can improve the SDT *** vivo studies further display that the increased blood supply by the mild photothermal effect can significantly relieve hypoxia in the tumor microenvironment,showing photothermal therapy(PTT)enhanced *** importantly,the H-Ti_(3)C_(2)-PEG NSs can be biodegraded and excreted out of the body,showing no significant long-term *** work develops the defective H-Ti_(3)C_(2) NSs as high-efficiency and safe sonosensitizers for photothermal-enhanced SDT of cancer,extending the biomedical application of MXene-based nanoplatforms.

关键词： Ti_(3)C_(2)MXenes Oxygen defect sonosensitizers Sonodynamic therapy Biosafety

Phthalocyanine iron nanodots for combined chemodynamic-sonodynamic cancer therapy

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Science China Materials 2022年第9期65卷 2600-2608页

作者： Yuehan Gong Xianwen Wang Fei Gong Guangqiang Li Yuqi Yang Linqian Hou Qiao Zhang Zhuang Liu Liang Cheng Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and DevicesSoochow UniversitySuzhou 215123China

Sonodynamic therapy(SDT)is a new non-invasive treatment method that has received widespread attention due to its deep tissue penetration and high ***,the low sonodynamic efficiency of sonosensitizers makes SDT poorly effective and limits its ***,it is urgent to prepare safe and highly efficient ***,a new kind of sonosensitizer,iron phthalocyanine nanodots(FePc NDs),is fabricated via a facile thermal organic-phase synthesis procedure for enhanced SDT against *** to the presence of Fe,FePc NDs can also be used as Fenton reagents to efficiently generate hydroxyl radicals(·OH)in the presence of hydrogen peroxide(H_(2)O_(2)).Notably,after modification with polyethylene glycol(PEG),FePc-PEG NDs exhibit remarkable biocompatibility and physiological stability,as well as good tumor accumulation *** with the control group,in vitro and in vivo experimental results demonstrate obvious cell killing efficiency and significant tumor suppression with the treatment of FePc-PEG NDs under ultrasound(US)*** importantly,FePc-PEG NDs have good biological safety and do not cause any adverse effects on *** work highlights the use of FePc-PEG NDs as a highly effective and low-toxic sonosensitizer for enhanced SDT.

关键词： phthalocyanine iron nanodots sonosensitizers sonodynamic therapy chemodynamic therapy toxicity

Piezotronic and piezo-phototronic effects on sonodynamic disease therapy

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BMEMat(BioMedical Engineering Materials) 2023年第1期1卷 3-18页

作者： Yunchao Zhao Tian Huang Xiaodi Zhang Yuanbo Cui Lili Zhang Linlin Li Zhong Lin Wang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijingChina Center on Nanoenergy Research School of Physical Science and TechnologyGuangxi UniversityNanningChina Department of Neurology Institute for Cell EngineeringJohns Hopkins University School of MedicineBaltimoreUSA Santa Clara University Santa ClaraUSA HCA Florida Healthcare Westside/Northwest Hospital Internal Medicine PlantationUSA School of Nanoscience and Technology University of Chinese Academy of SciencesBeijingChina Georgia Institute of Technology AtlantaUSA

With the development of engineered nanomaterials and nanomedicines,uti-lization of nanomaterials to generate excessive reactive oxygen species underexogenous ultrasound(US)irradiation for realizing disease therapy,namelysonodynamic therapy(SDT),has attracted widespread *** traditional photodynamic therapy,US shows deeper tissue penetration toreach deep-seated ***,the development of high-efficiencysonosensitizers remains one of the gravest challenges in current relatedresearch and future clinical ***,benefiting from the piezo-tronic and piezo-phototronic effects,novel sonosensitizers based on piezo-electric semiconductor(PS)nanomaterials have exhibited inspiring applicationprospects in *** this review,we outline the structures and physico-chemical properties of PS nanomaterials that has potential applications inSDT,and introduce the presumed mechanisms of PS nanomaterials in ***,the latest research progress of PS nanomaterials as sonosensitizers incancer therapy and antibacterial applications are ***,theexisting challenges and future development trends in this field are prospected.

关键词： cancer therapy piezo-phototronic effect piezoelectric effect piezoelectric semiconductor sonodynamic therapy sonosensitizers