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Primary testicular neuroendocrine tumor with liver lymph node metastasis: A case report and review of the literature

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World Journal of Clinical Cases 2022年第32期10卷 12028-12035页

作者： Tong Xiao Long-Hua Luo Liang-Fei Guo Li-Qin Wang Liang Feng Department of Urology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina.

BACKGROUND Primary testicular neuroendocrine tumors(TNETs)are sporadic,accounting for only 0.23%of all testicular *** cases have been reported in the literature,and no uniform treatment protocol *** report a case of a primary TNET with liver lymph node metastasis diagnosed at the age of 24 years and discuss its clinicopathological features,diagnosis,differential diagnosis,treatment,and *** SUMMARY We report the case of a 24-year-old patient with a primary TNET with liver lymph node *** patient was found to have a right testicular swelling of about 3 cm×4 cm in size with unclear borders and no testicular pressure pain seven years ago without any examination or *** month ago,an ultrasound examination was performed for persistent enlargement of the right testis,which showed an occupying lesion of the right testis approximately 110 mm×102 mm×82 mm in *** resonance imaging scan of the testis(plain scan)showed that the right testis was an occupying lesion with inhomogeneous density and mixed signal,the boundary was still clear,and the possibility of seminoma was considered;chest X-ray and computed tomography did not show any apparent *** patient underwent radical orchiectomy,and the pathological examination suggested a right TNET with a typical carcinoid tumor histological *** month after the surgery,the patient received nine cycles of lanreotide chemotherapy at a dose of 90 mg/mo without adverse *** distant lymph node or other organ metastases were detected at *** is in good physical condition and attends regular follow-up *** Neuroendocrine tumors are rare in clinical practice,and the diagnosis mainly relies on the characteristics of microscopic tumor cells and immunohistochemical *** involves radical *** it is accompanied by distant lymph node metastasis and the metastatic lesion can be resected,it should be surgically removed;if it cannot b

关键词： Testis Neuroendocrine tumor Immunohistochemistry Differential diagnosis somatostatin analog Lanreotide Liver metastasis Treatment Case report

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Advancements in medical treatment for pancreatic neuroendocrine tumors:A beacon of hope

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World Journal of Gastroenterology 2024年第12期30卷 1670-1675页

作者： Somdatta Giri Jayaprakash Sahoo Department of Endocrinology and Metabolism Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherry605006India

This editorial highlights the remarkable advancements in medical treatment strategies for pancreatic neuroendocrine tumors(pan-NETs),emphasizing tailored approaches for specific *** surgery and somatostatin analogs(SSAs)play pivotal roles in managing tumors,while palliative options such as molecular targeted therapy,peptide receptor radionuclide therapy,and chemotherapy are reserved for SSA-refractory ***,insul-inomas,glucagonomas,carcinoid tumors and VIPomas necessitate distinct thera-peutic *** the genetic basis of pan-NETs and exploring immunotherapies could lead to promising avenues for future *** review underscores the evolving landscape of pan-NET treatment,offering renewed hope and improved outcomes for patients facing this complex disease.

关键词： Pancreatic neuroendocrine tumor Medical management somatostatin analog Immunotherapy Everolimus

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EFFECT OF PREOPERATIVE USE OF LONG-ACTING OCTREOTIDE ON GROWTH HORMONE SECRETING PITUITARY ADENOMA AND TRANSSPHENOIDAL SURGERY

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Chinese Medical Sciences Journal 2005年第1期20卷 23-26,页

作者： JianYin Chang-baoSu Zhi-qinXu YiYang Wen-binMa WeiTao ZhongYang Xue-weiXia DepartmentofNeurosurgery PekingUnionMedicalCollegeHospitalChineseAcademyofMedicalSciences＆PekingUnionMedicalCollegeBeijing100730

Objective To investigate whether somatostatin analog octreotide long acting release (LAR) shrinks growth hormone (GH) secreting adenomas, and improves the results of subsequent transsphenoidal surgery. Methods Seventeen previously untreated active acromegalic patients with pituitary adenomas were treated with LAR (30 mg intramuscular injection every 28 days) for 3 months prior to transsphenoidal surgery. Clinical reaction, mean GH secretion, and tumor volume were measured under basal conditions and after LAR treatment. Results Presurgical treatment improved acromegaly symptoms and induced a significant reduction of GH under the 5 ng/mL limit in microadenoma (P 25%) occurred in the macroadenoma group. Statistical analysis showed tumor shrinkage caused by LAR was greater in macroadenoma group than that in microadenoma group (P < 0.05). During operation, adenoma was soft in 15 cases, with the exception of 2 cases in which the soft tumor was divided by fibrous septa, but all tumor removal was smooth. Conclusions A short term administration of preoperative LAR may induce a significant decrease in GH-secretion level and adenoma volume. Presurgical use of octreotide LAR improves surgical results especially in macroadenomas.

关键词： pituitary adenoma somatostatin analog transsphenoidal surgery

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Surgical treatment of non-functioning pancreatic neuroendocrine tumors:current controversies and challenges

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Journal of Pancreatology 2020年第2期3卷 51-58页

作者： Memeh Kelvin O. Vaghaiwalla Tanaz Keutgen Xavier M. Section of Endocrine Surgery Division of General Surgery and Surgical OncologyDepartment of SurgeryThe University of Chicago MedicineChicagoILUSA

There has been a rising trend in the incidence and prevalence of non-functioning pancreatic neuroendocrine tumors(NFPanNETs).While a significant number of the newly diagnosed NFPanNETs are asymptomatic,a majority of patients will present with liver metastasis(LM)at the time of *** resection remains the only curative treatment,especially for localized *** a majority of small NFPanNETs are indolent,some are *** heterogeneity in tumor biology presents the surgeon with the unique challenge of determining which patient will benefit from surgery,given the morbidity of pancreatic *** has been a recent push for a more aggressive approach to the care of these patients,given the emergence of data supporting such ***,the risk of over or under treatment has generated immense debate amongst experts in the *** heterogeneity of current practice guidelines and institutional practices around the world is a reflection of the disparate opinion on the management of *** this review,we set out to examine the evidence regarding some of the most controversial and challenging aspects of the surgical treatment of *** evaluate the following questions;should patients with small NFPanNETs≤2 cm in size be resected;should patients with metastatic NFPanNETs undergo surgical debulking,and should there be resection of the primary tumor in the setting of non-resectable metastatic disease?Although there are currently no Level 1 data to answer these questions conclusively,we believe that the current literature supports a more aggressive approach to the management of NFPanNET.

关键词： Carcinoid tumors Enucleation Liver debulking Neuroendocrine cancer Neuroendocrine tumor Pancreatic enucleation Pancreatic tumor PRRT somatostatin analog

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