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somatostatin 3 loss of function impairs the innate immune response to intestinal inflammation

Aquaculture and Fisheries 2021年第6期6卷 548-557页

作者： Jing Ma Jie Chen Bruno Louro Rute S.T.Martins Adelino V.M.Canario International Research Center for Marine Biosciences Ministry of Science and TechnologyShanghai Ocean UniversityShanghai201306China Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources Ministry of EducationShanghai Ocean UniversityShanghai201306China National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean UniversityShanghai201306China CCMAR-Centre of Marine Sciences University of the AlgarveGambelas Campus8005-139FaroPortugal

somatostatin is a neuropeptide and a key regulator of the growth *** Sst encoding genes(sst1 to sst6)have been identified in teleost fish genomes but little is known about their *** present study aimed at replicating the context of the inflammatory bowel disease(IBD)and clarifying the involvement of sst3 in the intestine innate defence barrier in zebrafish *** first established a CRISP/Cas9 sst3 deficient line(MT)and analysed the morphological and transcriptomic response to 0.4%dextran sulfate sodium(DSS).Alcian blue staining of larval sections 6 days post fertilization showed an increased in acidic mucins in the intestinal bulb and mid-intestine,with a much stronger response in the MT compared to wild type(WT).The transcriptomic analysis revealed that WT and MT shared enriched gene ontology(GO)terms and pathways linked to catabolism,chondrocyte development,innate immune system,xenobiotic metabolism and oxidative *** contrast,the WT specific response to DSS was enriched in GO terms and pathways linked to transcription and translation,various developmental processes,regulation of biosynthetic processes,apelin signalling and apoptosis while the MT specific response included terms and pathways linked to protein metabolism and catabolic processes,extracellular matrix-receptor interaction and proteasome and chondrocyte ***,this study demonstrated that Sst3 deficiency impairs insulin growth factor and adipocytokine signalling exacerbating the inflammatory response to DSS.

关键词： somatostatin 3 Zebrafish IBD Inflammation RNA-Seq

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