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Correlation between soluble receptor for advanced glycation end products levels and coronary artery disease in postmenopausal nondiabetic women

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World Journal of Cardiology 2021年第5期13卷 130-143页

作者： Soumitra Ghosh Divya Kapoor Rajesh Vijayvergiya Sonal Sangwan Sujata Wangkheimayum Sakshi Mehta Veena Dhawan Department ofCardiology PGIMERChandigarh 160012India Department of Experimental Medicine and Biotechnology PGIMERChandigarh 160012India Department of Biochemistry PGIMERChandigarh 160012India

BACKGROUND The established cardiovascular risk factors cannot explain the overall risk of coronary artery disease(CAD),especially in ***,there is a growing need for the assessment of novel biomarkers to identify women at *** receptor for advanced glycation end products(RAGE)and its interaction with the advanced glycation end product(AGE)ligand have been associated with *** soluble fraction of RAGE(sRAGE)antagonizes RAGE signaling and exerts an antiatherogenic *** The study aim was to explore the association between plasma levels of sRAGE and CAD in nondiabetic postmenopausal *** This case-control study included 110 nondiabetic postmenopausal women who were enrolled in two *** I included 55 angiographically proven CAD subjects with>50%stenosis in at least one of the major coronary arteries and Group II included 55 healthy control women who did not have CAD or hadendent of other risk *** Our findings indicated that low sRAGE levels were independently associated with CAD in nondiabetic postmenopausal *** assessment of CAD in postmenopausal women can be improved by including sRAGE along with other risk factors.

关键词： Coronary artery disease soluble receptor for advanced glycation end products Postmenopausal status Nondiabetic females Correlation Regression

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