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Communication between bone marrow mesenchymal stem cells and multiple myeloma cells:Impact on disease progression

World Journal of Stem Cells 2023年第5期15卷 421-437页

作者： Daniel García-Sánchez Alberto González-González Ana Alfonso-Fernández Mónica Del Dujo-Gutiérrez Flor M Pérez-Campo Department of Molecular Biology_IDIVAL Faculty of MedicineUniversity of CantabriaSantander 39011CantabriaSpain Servicio de Traumatología y Cirugía Ortopédica Hospital Universitario Marqués de ValdecillaInstituto de Investigación Sanitaria Valdecilla(IDIVAL)Facultad de MedicinaUniversidad de CantabriaSantander 39008CantabriaSpain

Multiple myeloma(MM)is a hematological malignancy characterized by the accumulation of immunoglobulin-secreting clonal plasma cells at the bone marrow(BM).The interaction between MM cells and the BM microenvironment,and specifically BM mesenchymal stem cells(BM-MSCs),has a key role in the pathophysiology of this *** data support the idea that BM-MSCs not only enhance the proliferation and survival of MM cells but are also involved in the resistance of MM cells to certain drugs,aiding the progression of this hematological *** relation of MM cells with the resident BM-MSCs is a two-way *** modulate the behavior of BM-MSCs altering their expression profile,proliferation rate,osteogenic potential,and expression of senescence *** turn,modified BM-MSCs can produce a set of cytokines that would modulate the BM microenvironment to favor disease *** interaction between MM cells and BM-MSCs can be mediated by the secretion of a variety of soluble factors and extracellular vesicles carrying microRNAs,long non-coding RNAs or other ***,the communication between these two types of cells could also involve a direct physical interaction through adhesion molecules or tunneling ***,understanding the way this communication works and developing strategies to interfere in the process,would preclude the expansion of the MM cells and might offer alternative treatments for this incurable disease.

关键词： Multiple myeloma Mesenchymal stem cells Bone marrow microenvironment soluble factors Extra-cellular vesicles Cells adhesion molecules Tunnellingnanotubes

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Mesenchymal stem cells secretome:The cornerstone of cell-free regenerative medicine

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World Journal of Stem Cells 2020年第12期12卷 1529-1552页

作者： Alberto González-González Daniel García-Sánchez Monica Dotta JoséC Rodríguez-Rey Flor M Pérez-Campo Department of Molecular Biology_IDIVAL Faculty of MedicineUniversity of CantabriaSantander 39011CantabriaSpain

Mesenchymal stem cells(MSCs)are the most frequently used stem cells in clinical trials due to their easy isolation from various adult tissues,their ability of homing to injury sites and their potential to differentiate into multiple cell ***,the realization that the beneficial effect of MSCs relies mainly on their paracrine action,rather than on their engraftment in the recipient tissue and subsequent differentiation,has opened the way to cell-free therapeutic strategies in regenerative *** the soluble factors and vesicles secreted by MSCs are commonly known as *** secretome has a key role in cell-to-cell communication and has been proven to be an active mediator of immunemodulation and regeneration both in vitro and in ***,the use of secretome has key advantages over cell-based therapies,such as a lower immunogenicity and easy production,handling and ***,MSCs can be modulated to alter their secretome composition to better suit specific therapeutic goals,thus,opening a large number of *** these advantages now place MSCs secretome at the center of an important number of investigations in different clinical contexts,enabling rapid scientific progress in this field.

关键词： Mesenchymal stem cells Secretome soluble factors Extra-cellular vesicles Exosomes Bone regeneration

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