检索结果-南通市图书馆

Elevated soluble 4-1bb is associated with serum markers of hepatitis B virus in patients with chronic hepatitis B

World Journal of Clinical Cases 2021年第7期9卷 1619-1630页

作者： Meng-Ru Zhan Xiu-Zhu Gao Chang Wang Fei Peng Xiao-Mei Wang Hong-Qin Xu Jun-Qi Niu Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Phase I Clinical Research Center The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Previous studies have suggested that the costimulatory molecule 4-1bb plays pivotal roles in regulating immunity during chronic viral ***,up to now,there are few studies about 4-1bb in chronic hepatitis B(CHB).AIM To clarify this issue,we report our comprehensive study results on the expression levels of 4-1bb in patients with *** From September 2018 to June 2019,a total of 64 patients with CHB were recruited from the Department of Hepatology,The First Hospital of Jilin *** blood samples were collected from 52 treatment-naïve and 12 entecavir-treated patients with CHB as well as 37 healthy donors(including 24 healthy adults and 13 healthy children).The levels of soluble 4-1bb(s4-1bb)in plasma were measured by ELISA.4-1bb mRNA expression in peripheral blood mononuclear cells was detected by real-time quantitative *** The s4-1bb levels in the plasma of patients with CHB were significantly higher than those in healthy adults(94.390±7.393 ng/mL vs 8.875±0.914 ng/mL,P4-1bb level in plasma was significantly increased in patients with a higher viral load and a disease flare ***,there were no significant differences between treatment-naïve and entecavir-treated ***,among treatment-naïve patients with CHB,the levels of s4-1bb in plasma had a significant positive correlation with hepatitis B surface antigen,hepatitis B virus DNA,hepatitis B e antigen,and triglyceride levels(r=0.748,P406,P=0.004;r=0.356,P=0.019 and r=-0.469,P=0.007,respectively).The 4-1bb mRNA expression was higher in the peripheral blood mononuclear cells of patients with CHB than in the peripheral blood mononuclear cells of healthy adults,but the difference was not statistically *** These results suggest that the levels of s4-1bb may be associated with pathogenesis of hepatitis B virus and therefore may be a promising biomarker for disease progression.

关键词： Hepatitis B virus Hepatitis B Chronic 4-1bb soluble 4-1bb Hepatitis B virus serum marker

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：