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Adjuvant transcatheter arterial chemoembolization after curative resection for hepatocellular carcinoma patients with solitary tumor and microvascular invasion: a randomized clinical trial of efficacy and safety

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Cancer Communications 2018年第1期38卷 655-666页

作者： Wei Wei Pei-En Jian Shao-Hua Li Zhi-Xing Guo Yong-Fa Zhang Yi-Hong Ling Xiao-Jun Lin Li Xu Ming Shi Lie Zheng Min-Shan Chen Rong-Ping Guo State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Hepatobiliary and Pancreatic Surgery Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Medical Imaging Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Background:The optimal strategy for adjuvant therapy after curative resection for hepatocellular carcinoma(HCC)patients with solitary tumor and microvascular invasion(MVI)is *** trial evaluated the efficacy and safety of adjuvant transcatheter arterial chemoembolization(TACE)after hepatectomy versus hepatectomy alone in HCC patients with a solitary tumor≥5 cm and ***:In this randomized,open-labeled,phase III trial,HCC patients with a solitary tumor≥5 cm and MVI were randomly assigned(1:1)to receive either 1-2 cycles of adjuvant TACE after hepatectomy(Hepatectomy-TACE)or hepatectomy alone(Hepatectomy Alone).The primary endpoint was disease-free survival(DFS);the secondary end-points included overall survival(OS)and adverse ***:Between June 1,2009,and December 31,2012,250 patients were enrolled and randomly assigned to the Hepatectomy-TACE group(n=125)or the Hepatectomy Alone group(n=125).Clinicopathological characteristics were balanced between the two *** median follow-up time from randomization was 37.5 months[interquartile range 18.3-48.2 months].The median DFS was significantly longer in the Hepatectomy-TACE group than in the Hepatectomy Alone group[17.45 months(95%confidence interval[CI]11.99-29.14)vs.9.27 months(95%CI 6.05-13.70),hazard ratio[HR]=0.70(95%CI 0.52-0.95),P=0.020],*** median OS was also significantly longer in the Hepatectomy-TACE group than in the Hepatectomy Alone group[44.29 months(95%CI 25.99-62.58)vs.22.37 months(95%CI 10.84-33.91),HR=0.68(95%CI 0.48-0.97),P=0.029].Treatment-related adverse events were more frequently observed in the Hepatectomy-TACE group,although these were generally mild and *** most common grade 3 or 4 adverse events in both groups were neutropenia and liver ***:Hepatectomy followed by adjuvant TACE is an appropriate option after radical resection in HCC patients with solitary tumor≥5 cm and MVI,with acceptable toxicity.

关键词： solitary tumor Hepatocellular carcinoma Adjuvant therapy Transcatheter arterial chemoembolization Hepatectomy alone Microvascular invasion

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Late-onset non-islet cell tumor hypoglycemia: A case report

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World Journal of Clinical Cases 2021年第1期9卷 163-169页

作者： Shunichi Matsumoto Eijiro Yamada Yasuyo Nakajima Naoki Yamaguchi Takashi Okamura Toshiki Yajima Satoshi Yoshino Kazuhiko Horiguchi Emi Ishida Masashi Yoshikawa Jun Nagaoka Sho Sekiguchi Mai Sue Shuichi Okada Izumi Fukuda Ken Shirabe Masanobu Yamada Department of Medicine and Molecular Science Gunma University Graduate School of MedicineMaebashi 371-8511GunmaJapan Division of General Thoracic Surgery Integrative Center of General SurgeryGunma University HospitalMaebashi 371-8511GunmaJapan Department of Endocrinology Diabetes and MetabolismGraduate School of Medicine Nippon Medical SchoolTokyo 1138602Japan

BACKGROUND Hypoglycemia due to non-insulin-producing tumors is referred to as non-islet cell tumor hypoglycemia(NICTH).As NICTH is a rare lesion,the natural course of NICTH is not well *** report a case of NICTH that was observed 30 years before the onset of *** SUMMARY A 50-year-old man was diagnosed with an abnormal right chest shadow during a routine X-ray examination,but no further examination was undertaken because the lesion appeared *** years after the tumor discovery,the patient was admitted to the hospital with symptoms of severe hypoglycemia,which was diagnosed as NICTH based on a complete *** tumor was resected and found to be a solitary fibrous mass(15.6 cm×13.7 cm×10.4 cm);thereafter,the patient’s blood glucose levels normalized and he completely *** NICTH can have an acute onset,even if the tumor has been present and asymptomatic over a long time period.

关键词： Hypoglycemia Non-islet cell tumor hypoglycemia Blood glucose solitary tumor Late onset Case report Insulin-like growth factor II

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Clinicopathological characteristics and longterm survival of patients with synchronous multiple primary gastrointestinal stromal tumors: A propensity score matching analysis

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World Journal of Gastroenterology 2021年第36期27卷 6128-6141页

作者： Hao Wu Chen Li Han Li Liang Shang Hai-Yan Jing Jin Liu Zhen Fang Feng-Ying Du Yang Liu Meng-Di Fu Ke-Wei Jiang Le-Ping Li Department of Gastroenterological Surgery Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinan 250021Shandong ProvinceChina Department of Gastroenterological Surgery Peking University People’s HospitalBeijing 100044China Department of General Surgery The First Affiliated Hospital of Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Digestive tumor Translational Medicine Engineering Laboratory of Shandong ProvinceShandong Provincial HospitalJinan 250021Shandong ProvinceChina Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250021Shandong ProvinceChina Department of Pathology Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinan 250021Shandong ProvinceChina Department of Gastroenterology Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinan 250021Shandong ProvinceChina Department of Clinical Medicine Cheeloo College of MedicineShandong UniversityJinan 250021Shandong ProvinceChina

BACKGROUND Multiple gastrointestinal stromal tumors(MGISTs)are specific and *** is known about the impact of MGISTs on the survival of patients with gastrointestinal stromal tumors(GIST).The diagnosis,treatment and follow-up strategies of MGISTs is not specifically described in *** To compare the clinicopathological characteristics and prognosis of MGISTs and solitary GISTs(SGISTs)METHODS Patients diagnosed with primary GISTs from March 2010 to January 2020 were *** to the inhomogeneous distribution of several baseline characteristics and uneven MGIST and SGIST group sizes,propensity score matching was performed according to comorbidities,body mass index,tumor location,mitotic index,sex,age and American Society of Anesthesiologists *** in clinicopathological characteristics and prognosis between patients with MGISTs and patients with SGISTs were *** Among the entire cohort of 983 patients,the incidence of MGISTs was 4.17%.Before matching,patients with MGISTs and those with SGISTs had disparities in body mass index,surgical approach,tumor size and mitotic *** 1:4 ratio matching,the clinical baseline data were *** 5-year progression-free survival rate was 52.17%in the MGIST group and 75.00%in the SGIST group(P=0.031).On multivariate analysis,tumor location,tumor size,mitotic index,imatinib treatment and MGISTs(hazard ratio=2.431,95%confidence interval=1.097-5.386,P=0.029)were identified as independent prognostic factors of progression-free ***,overall survival was similar between the SGIST and MGIST *** Patients with MGISTs had poorer progression-free survival than patients with *** criteria and diagnostic and treatment strategies should be developed to achieve personalized precision therapy and maximize the survival benefit.

关键词： Gastrointestinal stromal tumors Synchronous Multiple tumors solitary tumor Propensity score matching Prognosis

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Anatomical vs nonanatomical liver resection for solitary hepatocellular carcinoma:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2021年第11期13卷 1833-1846页

作者： Hu Liu Feng-Juan Hu Hui Li Tian Lan Hong Wu Department of Liver Surgery Liver Transplantation DivisionLaboratory of Liver SurgeryWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina The Center of Gerontology and Geriatrics West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND The long-term survival of patients with solitary hepatocellular carcinoma(HCC)following anatomical resection(AR)vs non-anatomical resection(NAR)is still *** is necessary to investigate which approach is better for patients with solitary *** To compare perioperative and long-term survival outcomes of AR and NAR for solitary *** We performed a comprehensive literature search of PubMed,Medline(Ovid),Embase(Ovid),and Cochrane *** of any age and sex,who underwent liver resection,were considered following the following criteria:(1)Studies reporting AR vs NAR liver resection;(2)Studies focused on primary HCC with a solitary tumor;(3)Studies reporting the long-term survival outcomes(>5 years);and(4)Studies including patients without history of preoperative *** main results were overall survival(OS)and disease-free survival(DFS).Perioperative outcomes were also *** A total of 14 studies,published between 2001 and 2020,were included in our meta-analysis,including 9444 patients who were mainly from China,Japan,and *** was performed on 4260(44.8%)*** synthetic results showed that the 5-year OS[odds ratio(OR):1.19;Psolitary HCC.

关键词： Hepatocellular carcinoma Anatomical resection Non-anatomical resection Meta-analysis Systematic review solitary tumor

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Microwave ablation in solitary hepatocellular carcinoma within 3-5 cm requiring consideration

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Hepatobiliary Surgery and Nutrition 2023年第4期12卷 622-624页

作者： Lingmin Jiang Chen Liang Feihu Xie Yun Zheng Department of Liver Surgery Sun Yat-sen University Cancer CenterGuangzhouChina State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer CenterGuangzhouChina

Hepatocellular carcinoma(HCC)is a global health issue and remains the second most common cause of cancer-related deaths(1).With in-depth research in this field,treatment options are becoming more *** resection,thermal ablation,and transplantation could offer a curative chance in early *** ablation therapy,including radiofrequency ablation(RFA),microwave ablation(MWA),etc.,is a proven cure tactic for early-stage ***,MWA may provide superior tumor control over RFA and other ablations for patients with perivascular HCC(2).

关键词： Hepatocellular carcinoma(HCC) solitary tumor microwave ablation(MWA)

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