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Journal of Environmental Science and Engineering 2010年第3期4卷 81-84页

作者： X. Zhang J. Wang R.H. Zhu Department of Chemistry Capital Normal University Beijing 100048

A new analytical procedure based on solid-phase extraction method coupled to GC-FID has been developed and validated for the determination of five phthalate esters （PAEs）（dimethyl-（DMP）, diethyl-（DEP）, di-n-butyl-（DBP）, di-2-ethylhexyl- （DEHP）, di-n-octyl-（DOP）） in fish samples. There was a good linear relationship in the range of 0.05-10μg with the detection limits of 0.09-0.16ng .The recoveries obtained for PAEs ranged from 88.6% to 96.4%with RSD of 4.2%-10.2%.The applicability of the developed method was demonstrated for real fish samples.

关键词： Phthalate esters solid-phase extraction Capillary Gas Chromatography.

A Sensitive High-Performance Liquid Chromatography Coupled with solid- phase extraction for Determination of Fexofenadine in Beagle Plasma

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Journal of Chinese Pharmaceutical Sciences 2005年第4期14卷 246-249页

作者：马雷殷莉莉孙进何仲贵沈阳药科大学药剂教研室辽宁沈阳110016

Introduction Fexofenadine, the primary metabolite of terfenadine, is a selective and peripherally acting Hl receptor antagonist and has been developed as a non-sedating H1 antihistaminic drug. In clinical studies, it ... 详细信息

关键词： RP-HPLC fexofenadine beagles plasma solid-phase extraction

HPLC Determination of Captopril in Human Plasma with Pre-column Derivation and solid-phase extraction and Studies on Its Pharmacokinetic and Relative Bioavailability

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Journal of Chinese Pharmaceutical Sciences 2001年第3期10卷 152-156页

作者：丁劲松张毕奎李焕德刘义钊邓航中南大学湘雅二医院长沙410011 湖南常德第一人民医院常德415700 桂林医学院附属医院桂林510012

A new pre-column derivation HPLC method with solid-phase extraction to determine captopril in human plasma was established. Derivation products were extracted by a solid-phase extraction method after the reagent, p-a-dibromoacetophenone(p-BPB), was added in the plasma samples. The samples were analyzed in a VP-ODS column with UV-detector. The calibration curve of captopril was linear within the range of 5~1000 ngmL-1 with r=0.9987, the recovery of this method was 98.652.04%, within day and between day RSD were no more than 3.4% and 8.4% respectively. To study the pharmacokinetics and the relative bioavailability of captopril tablets, two formulations of captopril tablets were given to 18 healthy male volunteers according to a randomized 2-way cross-over design with a 1-week washout period. The respective AUC0~6 , Cmax and Tmax values of the two formulations were 424.5125.7 and 439.4113.3 mghL-1; 505.9244.6 and 504.8172.2 mgL-1; 0.6620.181 and 0.5280.176 h. Results from statistics analysis showed that there were no significant difference between the AUC0~6 , Cmax and Tmax values of the two formulations, The relative bioavailability of tablets I with respect to II was 96.114.6% from AUC0~6 measurement. Bioequivalance was observed between the two tablets.

关键词： Captopril solid-phase extraction HPLC Pharmacokinetics Bioavailability

Separation and Enrichment of Melamine in Feed by a New Molecularly Imprinted solid-phase extraction Column

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Animal Husbandry and Feed Science 2014年第1期6卷 10-13页

作者： Huang Huabin Zhuang Zhixia Zhou Yanli Zhao Li Wang Xiaoru Xiamen Huaxia Vocational College College of Chemistry and Chemical Engineering Xiamen University

[ Objective] The research aimed to develop a new molecular imprinting solid-phase extraction column for the separation and enrichment of melamine in feed. [ Method] The molecular imprinting polymer of melamine was prepared by mass polymerization method. This polymer was used as filler to prepare molecular imprinting polymer solid-phase extraction（MIP-SPE） column of melamine. The solid-phase extraction conditions were optimized and melamine content in concentrated solution was determined by using HPLC. [ Result] Melamine eould be separated selectively from feed and enriehed by self-made MIP-SPE column. It could wipe off complex matrix from feed and the addition recovery rate was 95%. The contrast experiment between MIP-SPE column and NMIP-SPE （ non-imprinted polymer- solid phase extraction） column showed that the extraction efficiency of the former was obviously higher than the latter. [ Conclusion] The home-made MIP- SPE column could be used to separate and enrich melamine in feed efficiently, with a broad application prospect.

关键词： Molecular imprinting solid-phase extraction Feed Melamine

Analysis of trace mercury in water by solid phase extraction using dithizone modified nanometer titanium dioxide and cold vapor atomic absorption spectrometry

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Rare Metals 2007年第6期26卷 541-546页

作者： MA Xiaoguo HUANG Bei CHENG Meiqing Faculty of Environmental Science and Engineering Guangdong University of Technology Guangzhou 510090 China Department of Chemical Engineering Maoming University Maoming 525000 China

A new method for analysis of trace mercury in water samples was developed, based on the combination of preconcentration/separation using dithizone-modified nanometer titanium dioxide （TiO2） as a solid phase extractant and determination by cold vapor atomic adsorption spectrometry （CVAAS）. Dithizone was dissolved with alcohol and loaded on the surface of nano-sized TiO2 powders by stirring. The static adsorption behavior of Hg^2＋on the dithizone-modified nanoparficles was investigated in detail. It was found that excellent adsorption ratio for Hg^2＋ could be obtained in the pH range of 7-8 with an oscillation time of 15 rain, and a 5 mL of 3.5 mol·L^-1 HCI solution could quantitatively elute Hg^2＋ from nanometer TiO2 powder. Common coexisting ions caused no obvious influence on the determination of mercury. The mechanisms for the adsorption and desorption were discussed. The detection limit （30） for Hg^2＋ was calculated to be 5 ng·L^-1. The proposed method was applied to the determination of Hg^2＋ in a mineral water sample and a Zhujiang River water sample. By the standard addition method, the average recoveries were found to be 94.4%-108.3% with RSD （n = 5） of 2.9%-3.5%.

关键词： analytical chemistry mercury solid-phase extraction TiO2 nanoparticle cold vapor atomic adsorption spectrometry (CVAAS)

Determination of 4-Nitrophenol in water samples by Fluorescence Quenching Combined with Molecularly Imprinted solid-phase extraction

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Determination of 4-Nitrophenol in water samples by Fluoresce...

“2011国际化学年在中国”——中国化学会第十届全国发光分析学术研讨会

作者： Turghun Muhammad Abdukirem Kadier Abdurahman Tursun Key Laboratory of Oil and Gas Fine Chemicals Ministry of Education and Xinjiang Uyghur Autonomous RegionCollege of Chemistry and Chemical EngineeringXinjiang University

In this work,a novel fluorescence quenching method combined with molecularly imprinted solid-phase extraction was proposed and applied for the determination of 4-Nitrophenol(4NP) in water samples.A molecularly imprinted polymer(MIP) for 4NP was synthesized by bulk polymerization using 4-vinylpyridine as functional monomer,trimethylolpropane trimethacrylate as crosslinker in acetonitrile.

关键词： 4-Nitrophenol fluorescence quenching molecularly imprinted polymer solid-phase extraction

Molecular Imprinted solid-phase extraction of Huperzine A from Huperzia serrata

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Molecular Imprinted Solid-phase Extraction of Huperzine A fr...

第五届全国化学生物学学术会议

作者： Wang GuoSong Cao QiuE Zhu XiuFang Ding ZhongTao~* Key Laboratory of Medicinal Chemistry for Nature Resource,Ministry of Education,School of Chemical Science and Technology,Yunnan University,Kunming 650091,Yunnan,P.R.China

＜正＞Huperzine A,a lycopodium alkaloid,is recognized to be a promising lead structure in the therapy of senile dementia and cognitive impairment in Alzheimer’s *** this work,some molecularly imprinted polymers（MIPs）of huperzine A were synthesized with methacrylic acid, acrylamide,2-vinylpyridine,or 4-vinylpyridine as functional monomer,***

关键词： Huperzia serrata imprinted polymers Huperzine A solid-phase extraction

Novel surface dummy-template imprinted magnetic nanoparticles for solid-phase extraction of bisphenol A

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Novel surface dummy-template imprinted magnetic nanoparticle...

中国化学会第十一届全国生物医药色谱及相关技术学术交流会

作者： Xiao Wu Xiaoliang Zhu Yarong Li Chiyang He School of Chemistry and Chemical Engineering Wuhan Textile University

＜正＞In this work,a new type of hexafluorobisphenol A imprinted magnetic nanoparticles（MNPs）was prepared via a hybrid imprinting strategy for solid-phase extraction of bisphenol A（BPA）.The new imprinted MNPs were characterized by FT-IR,TGA,TEM,XRD and *** imprinted MNPs showed higher binding ability for BPA than the non-imprinted MNPs and a fast binding *** used as a SPE sorbent for BPA,the extraction efficiencies were 95-104%within the concentration of 10-100 ng/m L

关键词： dummy-template imprinting magnetic nanoparticle solid-phase extraction bisphenol A HPLC-UV

Determination of vitamin A in blood serum by solid-phase extraction using C16-modified attapulgite

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Determination of vitamin A in blood serum by solid-phase ext...

2019浙江省妇产科医师大会及妇产科学学术年会

作者： Rongrong Xuan Tingting Wang Chunyan Hou Xie Li Ying Li Yihui Chen Yajie Gao Dan Qiu Xunwen Xiao Lihua Zhang Yukui Zhang Obstetrical Department Affiliated Hospital of Medical School Ningbo University and Ningbo City Third Hospital Fenghua Institute Ningbo University of Technology School of Materials and Chemical Engineering Ningbo University of Technology Key Laboratory of Separation Science for Analytical Chemistry National Chromatographic Research and Analysis CenterDalian Institute of Chemical PhysicsChinese Academy of Sciences Ningbo Customs district P.R.China

A C16-modified attapulgite was prepared via cation exchange,and then utilized as a novel sorbent for solid-phase extraction(SPE) of vitamin A in blood serum of pregnant *** C16-modified attapulgite was characterized by fourier transform infrared *** factors for SPE,including methanol percentage in the sampling solvent and eluting solvent,pH in the eluting solvent,salt in the eluting solvent,sample loading volume and elution volume,were completely *** adsorption capacity of vitamin A was up to 28 mg/g according to the Langmuir isotherm *** the optimal SPE conditions,a simple C16-modified attapulgite-based SPE method for the determination of vitamin A in blood serum samples has been proposed,the limit of detection(LOD) was 0.001 μg/mL,and the recoveries were in the range of 86.9-92.8% with relative standard deviations for the intraday and inter-day less than 8.7%.Owing to the high adsorption capacity of vitamin A,this C16-modified attapulgite served as SPE sorbent could provide a promising tool for the determination of trace vitamin A in blood serum samples with limited available volume.

关键词： Attapulgite Blood serum samples Cetyltrimethyl ammonium bromide solid-phase extraction Vitamin A

Determination of vitamin A in blood serum by solid-phase extraction using C16-modified attapulgite

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Determination of vitamin A in blood serum by solid-phase ext...

2019长三角围产医学学术会议暨浙江省围产医学学术大会

作者： Rongrong Xuan Tingting Wang Chunyan Hou Xie Li Ying Li Yihui Chen Yajie Gao Dan Qiu Xunwen Xiao Lihua Zhang Yukui Zhang Obstetrical Department Affiliated Hospital of Medical School Ningbo University and Ningbo City Third Hospital Fenghua Institute Ningbo University of Technology School of Materials and Chemical Engineering Ningbo University of Technology Key Laboratory of Separation Science for Analytical Chemistry National Chromatographic Research and Analysis Center Dalian Institute of Chemical Physics Chinese Academy of Sciences Ningbo Customs district P.R.China

A C16-modified attapulgite was prepared via cation exchange, and then utilized as a novel sorbent for solid-phase extraction(SPE) of vitamin A in blood serum of pregnant women. The C16-modified attapulgite was characterized by fourier transform infrared spectroscopy. Several factors for SPE, including methanol percentage in the sampling solvent and eluting solvent, pH in the eluting solvent, salt in the eluting solvent, sample loading volume and elution volume, were completely investigated. The adsorption capacity of vitamin A was up to 28 mg/g according to the Langmuir isotherm model. Under the optimal SPE conditions, a simple C16-modified attapulgite-based SPE method for the determination of vitamin A in blood serum samples has been proposed, the limit of detection(LOD) was 0.001 μg/mL, and the recoveries were in the range of 86.9-92.8% with relative standard deviations for the intraday and inter-day less than 8.7%. Owing to the high adsorption capacity of vitamin A, this C16-modified attapulgite served as SPE sorbent could provide a promising tool for the determination of trace vitamin A in blood serum samples with limited available volume.

关键词： Attapulgite Blood serum samples Cetyltrimethyl ammonium bromide solid-phase extraction Vitamin A