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Surface activity of cancer cells:The fusion of two cell aggregates

BIOCELL 2023年第1期47卷 15-25页

作者： IVANA PAJIC-LIJAKOVIC MILAN MILIVOJEVIC Faculty of Technology and Metallurgy Belgrade UniversityBelgradeSerbia

A key feature that distinguishes cancer cells from all other cells is their capability to spread throughout the *** how cancer cells collectively migrate by following molecular rules which influence the state of cell-cell adhesion contacts has been comprehensively formulated,the impact of physical interactions on cell spreading remains less *** effects of physical interactions exist as the interplay between various physical parameters such as(1)tissue surface tension,(2)viscoelasticity caused by collective cell migration,and(3)solid stress accumulated in the cell aggregate core *** review aims to point out the role of these physical parameters in cancer cell spreading by considering and comparing the rearrangement of various mono-cultured cancer and epithelial model systems such as the fusion of two cell *** epithelial cells undergo volumetric cell rearrangement driven by the tissue surface tension,which directs cell movement from the surface to the core region of two-aggregate systems,cancer cells rather perform surface cell *** cells migrate toward the surface of the two-aggregate system driven by the solid stress while the surface tension is significantly *** solid stress,accumulated in the core region of the two-aggregate system,is capable of suppressing the movement of epithelial cells that can undergo the jamming state transition;however,this stress enhances the movement of cancer *** have focused here on the multi-scale rheological modeling approaches that aimed at reproducing and understanding these biological systems.

关键词： Collective cell migration Tissue surface tension Surface activity of cancer cells Viscoelasticity solid stress The state of cell-cell adhesion contacts

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ONSET CONDITION OF STRAIN LOCALIZATION IN MATRIX OF SATURATED POROUS MEDIA

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Applied Mathematics and Mechanics(English Edition) 2005年第11期26卷 1475-1483页

作者：赵纪生陶夏新师黎静欧进萍 LIN Jian-zhong Institute of Engineering Mechanics China Earthquake Administration Harbin 150080 P.R. China School of Civil Engineering Harbin Institute of Technology Harbin 150006 P. R. China 不详

Based on governing equations of saturated porous media and Liapunov＇ s stability here, onset conditions matrix of porous media used by solid stress and Terzaghi＇s effective stress constitutive description under seepage flow state, are presented, which have different forms with different representation of the solid phase, matrix or skeleton, constitutive model of porous media. The main difference relates with how to describe the interaction between solid phase and liquid phase in constitutive model. The derived onset condition of strain localization under Terzaghi＇ s effective stress description can be used to interpret different failure types, piping effect, landslides and mudflows, by means of the type and the magnitude ratio of relative movement between solid phase and liquid phase. Examples here illuminate the onset condition of how to work.

关键词： porous medium solid stress Terzaghi's effective stress constitutive model of matrix onset condition of strain localization

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