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Adult pancreatoblastoma: Current concepts in pathology

World Journal of Gastroenterology 2021年第26期27卷 4172-4181页

作者： Ayo O Omiyale Department of Cellular Pathology Imperial College Healthcare NHS TrustLondon W68RFUnited Kingdom

Adult pancreatoblastoma is an exceptionally rare malignant tumour of the pancreas that mimics other solid cellular neoplasms of the pancreas,which may pose diagnostic *** of its rarity,little is known about its clinical and pathologic *** article reviews the clinical and pathologic features of pancreatoblastoma in adults including differential diagnosis,treatment,and *** pancreatoblastoma commonly occurs in childhood,there have now been more than 70 adult pancreatoblastomas described in the *** is a slight male *** are no symptoms unique to pancreatoblastomas and adult patients are frequently *** most common presenting symptom is abdominal ***,the tumours are often large and ***,pancreatoblastomas are composed of neoplastic cells with predominantly acinar differentiation and characteristic squamoid *** tumours are positive for trypsin,chymotrypsin,lipase,and *** of heterozygosity on chromosome 11p is the most common molecular alteration in *** pancreatoblastomas are aggressive tumours with frequent local invasion,recurrence,and distant *** consists of surgical *** and radiotherapy may have a role in the treatment of recurrent,residual,unresectable,and metastatic *** is important to distinguish pancreatoblastomas from morphological mimics such as acinar cell carcinomas,solid pseudopapillary neoplasms,and pancreatic neuroendocrine neoplasms.

关键词： Pancreas Adult pancreatoblastoma pancreatic cancer solid pancreatic mass Non-ductal pancreatic tumours

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Role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer

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World Journal of Gastroenterology 2014年第31期20卷 10758-10768页

作者： Barbara Bournet Marion Gayral Jérme Torrisani Janick Selves Pierre Cordelier Louis Buscail Department of Gastroenterology CHU Toulouse Rangueil University of Toulouse INSERM UMR 1037 CHU Toulouse Rangueil University of Toulouse Department of Pathology CHU Toulouse Purpan University of Toulouse

pancreatic ductal adenocarcinoma remains one of the most deadly types of tumor. Endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA) is a safe, cost-effective, and accurate technique for evaluating and staging pancreatic tumors. However, EUS-FNA may be inconclusive or doubtful in up to 20% of cases. This review underlines the clinical interest of the molecular analysis of samples obtained by EUS-FNA in assessing diagnosis or prognosis of pancreatic cancer, especially in locally advanced tumors. On EUS-FNA materials DNA, mRNA and miRNA can be extracted, amplified, quantified and subjected to methylation assay. Kras mutation assay, improves diagnosis of pancreatic cancer. When facing to clinical and radiological presentations of pseudo-tumorous chronic pancreatitis, wildtype Kras is evocative of benignity. Conversely, in front of a pancreatic mass suspected of malignancy, a mutated Kras is highly evocative of pancreatic adenocarci-noma. This strategy can reduce false-negative diagnoses, avoids the delay of making decisions and reduces loss of surgical resectability. Similar approaches are conducted using analysis of miRNA expression as well as Mucin or markers of invasion(S100P, S100A6, PLAT or PLAU). Beyond the diagnosis approach, the prediction of response to treatment can be also investigated form biomarkers expression within EUS-FNA materials.

关键词： pancreatic ductal adenocarcinoma Endoscopic ultrasound-guided fine-needle aspiration solid pancreatic mass KRAS-mutation assay qPCR analysis Micro-RNA Chronic pancreatitis

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