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Prevention of grafted liver from reperfusive injury

World Journal of Gastroenterology 2001年第4期7卷 572-574页

作者： Kai Ma Yang Yu Xian-Min Bu Yan-Jun Li Xian-Wei Dai Liang Wang Yang Dai Hai-Ying Zhao Xiang-Hong Yang Department of General Surgery,Second Clinical College,China Medical University,Shenyang 110003,Liaoning Province,ChinaDepartrnent of Physiology,Shenyang Physical Education College,Shenyang,Liaoning Province,ChinaDepartment of Pathology,China Medical University,Shenyang,Liaoning Province,China Department of General Surgery Second Clinical College China Medical University Shenyang 110003 Liaoning Province China.

INTRODUCTIONThe incidence of primary non-function(PNF)of grafted liver in the early postoperative stage is 2%-23%[1-4],its main cause is the ischemic-rechemic injure[5,6].In this experiment,anisodamine was added into the preserving fluid and the grafted liver was rewarmed at different temperatures to protect the cell membranc and prevent ischemic-reperfusive injury.

关键词： Liver Transplantation Animals Body Temperature Drugs, Chinese Herbal Free Radical Scavengers Hepatocytes Lipid Peroxidation Liver Male Microscopy, Electron Rats Rats, Wistar Reactive Oxygen Species Reperfusion Injury control Research Support, Non-U.S. Gov't solanaceous alkaloids Superoxide Dismutase

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The effects of anisodamine and dobutamine on gut mucosal blood flow during gut ischemia/reperfusion

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World Journal of Gastroenterology 2002年第3期8卷 555-557页

作者： Sen Hu Zhi-Yong Sheng,Burns Institute,304th Hospital of PLA,Beijing 100037,China Burns Institute 304th Hospital of PLA 51 Fu Cheng Road Beijing 100037 China.

AIM: To determine if anisodamine is able to augment mucosal perfusion during gut I/R ischemia-reperfusion. METHODS: A jejunal sac was formed in Sprague Dawley rat. A Laser Doppler probe and a tonometer were inserted into the sac which was filled with saline. The superior mesenteric artery was occluded (SMAO)for 60 minutes followed by 90 minutes of reperfusion. At the end of 60 minutes of SMAO, either 0.2 mg/kg of anisodmine or dobutamine was injected into the jejunal sac. Laser Doppler mucosal blood flow and regional PCO2 (PrCO2)measurements were made. RESULTS: Mucosal blood flow was significantly increased at 30,60 and 90 minutes of reperfusion (R30, R60, R90) when intraluminal anisodamine or dobutamine was present compared to intraluminal saline only(44+/-3.3% or 48+/-4.1% vs 37+/-2.6% at R30, 57+/-5.0% or 56+/-4.7% vs 45+/-2.7% at R60, 64+/-3.3% or 56+/-4.2% vs 48+/-3.4% at R90,respectively P<0.05). Blood flow changes were also reflected by lowering of jejunal PrCO2 measurements after intraluminal anisodamine or dobutamine compared with that of the saline controls (41+/-3.1 mmHg or 44+/-3.0 mmHg vs 49+/-3.7 mmHg at R30,38+/-3.7 mmHg or 40+/-2.1 mmHg vs 47+/-3.8 mmHg at R60,34+/-2.1 mmHg or 39+/-3.0 mmHg vs 46+/-3.4 mmHg at R90, respectively, P<0.05). Most interesting finding was that there were significantly higher mucosal blood flow and lower jejunal PrCO2 in anisodamine group than those in dobutamine group at 90 minutes of reperfusion(64+/-3.3% vs 56+/-4.2% for blood flow or 34+/-2.1 mmHg vs 39+/-3.0 mmHg for PrCO2, respectively, P<0.05), suggesting that anisodamine had a more lasting effect on mucosal perfusion than dobutamine. CONCLUSION: Intraluminal anisodamine and dobutamine can augment mucosal blood flow during gut I/R and alleviate mucosal acidosis. The results provided beneficial effects on the treatment of splanchnic hypoperfusion following traumatic or burn shock.

关键词： Animals Carbon Dioxide Dobutamine Intestinal Mucosa Ischemia Jejunum Male Rats Rats, Sprague-Dawley Regional Blood Flow Reperfusion Injury Research Support, Non-U.S. Gov't solanaceous alkaloids

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Treatment of 104 Cases of Chemotherapy-Induced Leukopenia by Injection of Drugs into Zusanli

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Journal of Traditional Chinese Medicine 2001年第1期21卷 27-28页

作者：尹先哲尹德印刘新群丁旭萌周永生 The Second People's Hospital of Nanyang City Nanyang 473012 Henan Province

From April 1992 to April 1998, 104 cases of chemotherapy-induced leukopenia were treated by injection into Zusanli (ST 36) with a mixture consisting of dexamethasone, 654-2, ATP and inosine. The therapeutic results were satisfactory as reported in the following.Clinical Data In this series, all the 127 cases were definitely diagnosed by pathological examination. Of them, 93 were male and 34 female, ranging in age from 12 to 75 years. 38 cases were carcinoma of esophagus, 22 carcinoma of cardia of stomach, 21 cancer of lung, 11 hepatic carcinoma, 8 lymphoma, 8 mammary cancer, 7 carcinoma of colon, and 12 other kinds of the tumors. Leukocyte count was below 4.0×109/L in all the patients after being treated by chemotherapy.

关键词： Acupuncture Points Adenosine Triphosphate Adolescent Adult Aged Antineoplastic Agents Carcinoma, Squamous Cell Child Dexamethasone Esophageal Neoplasms Female Humans Injections Inosine Leukopenia Male Middle Aged solanaceous alkaloids Stomach Neoplasms

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