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Assessment of breast cancer immunohistochemistry and tumor characteristics in Nigeria

World Journal of Clinical Oncology 2020年第11期11卷 935-944页

作者： Usman Malami Aliyu Abdulrahaman Auwal Musa Department of Radiotherapy and Oncology Usmanu Danfodiyo University/Teaching HospitalSokoto 840212Nigeria Department of Histopathology Usmanu Danfodiyo University Teaching HospitalSokoto 840221Nigeria

BACKGROUND Female breast cancer is the leading type of cancer worldwide with an incidence of approximately 2.1 million in *** receptor status plays a vital role in its *** To determine the molecular expression pattern of biomarkers in breast cancer and their correlation with tumor *** This prospective study was designed to analyze expression patterns of estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor(HER2/neu)in breast cancer *** dataset has been taken from the Department of Radiotherapy and Oncology of Usmanu Danfodiyo University Teaching Hospital sokoto,Nigeria from 1 January 2015 to 2 December *** dataset had 259 records and 7 *** version 23.0 for statistical analysis was *** data analyzed demographic and other clinicopathological characteristics as categorical *** mean and standard deviation were determined for the quantitative *** A total of 259 breast cancer cases were included in the *** mean age was 48.3±11.0,with an age range of 26-80 years and a median age of 46 *** morphological categories were invasive ductal carcinoma 258(99.6%)and invasive lobular carcinoma 1(0.4%).ER,positivity increased in 73 patients(50%)under the age of 50 years,as well as PR positivity increased in 34 patients(23.6%)under the age of 50 ***/2neupositivity decreased in 8 patients(5.6%)under the age of 50 *** receptors were statistically significant with clinicopathological characteristics(P<0.05).CONCLUSION Our study showed that ER,PR and HER2/neuexpression had a strong correlation with age,tumor grade,tumor size and lymph node ***,hormone receptor assessment is highly recommended because of its significance in clinical management and prognostication.

关键词： Breast cancer Hormonal receptors sokoto state Tertiary Health Institution Northwestern Nigeria

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