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Nanofiber matrix formulations for the delivery of Exendin-4 for tendon regeneration: In vitro and in vivo assessment

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Bioactive Materials 2023年第7期25卷 42-60页

作者： Sama Abdulmalik Jack Gallo Jonathan Nip Sara Katebifar Michael Arul Amir Lebaschi Lucas N.Munch Jenna M.Bartly Shilpa Choudhary Ivo Kalajzic Yeshavanth Kumar Banasavadi-Siddegowdae Syam P.Nukavarapu Sangamesh G.Kumbar Department of Orthopedic Surgery University of Connecticut HealthFarmingtonCTUSA Department of Biomedical Engineering University of ConnecticutStorrsCTUSA Department of Materials Science and Engineering University of ConnecticutStorrsCTUSA Department of Physiology and Neurobiology University of ConnecticutStorrsCTUSA Department of Immunology Center on AgingUniversity of Connecticut HealthFarmingtonCTUSA Department of Reconstructive Sciences University of Connecticut HealthFarmingtonCTUSA Surgical Neurology Branch National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesdaMDUSA

Tendon and ligament injuries are the most common musculoskeletal injuries,which not only impact the quality of life but result in a massive economic *** interventions for tendon/ligament injuries utilize biological and/or engineered grafts to reconstruct damaged tissue,but these have *** matrices confer superior physicochemical properties over biological grafts but lack desirable bioactivity to promote tissue *** incorporating drugs can enhance bioactivity,large matrix surface areas and hydrophobicity can lead to uncontrolled burst release and/or incomplete release due to *** overcome these limitations,we evaluated the delivery of a peptide growth factor(exendin-4;Ex-4)using an enhanced nanofiber matrix in a tendon injury *** overcome drug surface binding due to matrix hydrophobicity of poly(caprolactone)(PCL)-which would be expected to enhance cell-material interactions-we blended PCL and cellulose acetate(CA)and electrospun nanofiber matrices with fiber diameters ranging from 600 to 1000 *** avoid burst release and protect the drug,we encapsulated Ex-4 in the open lumen of halloysite nanotubes(HNTs),sealed the HNT tube endings with a polymer blend,and mixed Ex-4-loaded HNTs into the polymer mixture before *** reduced burst release from~75%to~40%,but did not alter matrix morphology,fiber diameter,or tensile *** evaluated the bioactivity of the Ex-4 nanofiber formulation by culturing human mesenchymal stem cells(hMSCs)on matrix surfaces for 21 days and measuring tenogenic differentiation,compared with nanofiber matrices in basal media ***,we observed that Ex-4 nanofiber matrices accelerated the hMSC proliferation rate and elevated levels of sulfated glycosaminoglycan,tendon-related genes(Scx,Mkx,and Tnmd),and ECM-related genes(Col-Ⅰ,Col-Ⅲ,and Dcn),compared to *** then assessed the safety and efficacy of Ex-4 nanofiber matrices in a full-thickness rat Achilles tendon

关键词： Nanofiber matrix formulation Protein delivery soft tissue regeneration Halloysite nanotubes

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Cartilage and facial muscle tissue engineering and regeneration： a mini review

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Bio-Design and Manufacturing 2018年第2期1卷 115-122页

作者： Michael Del Monico Mohammadreza Tahriri Mina D. Fahmy Hamed Ghassemi Daryoosh Vashaee Lobat Tayebi Marquette University School of Dentistry Milwaukee WI 53233 USA Eye Research Center Farabi Eye Hospital Tehran University of Medical Sciences Tehran Iran Department of Electrical and Computer Engineering North Carolina State University Raleigh NC 27606 USA

Cartilage and facial muscle tissue provide basic yet vital functions for homeostasis throughout the body, making human survival and function highly dependent upon these somatic components. When cartilage and facial muscle tissues are harmed or completely destroyed due to disease, trauma, or any other degenerative process, homeostasis and basic body functions consequently become negatively affected. Although most cartilage and cells can regenerate themselves after any form of the aforementioned degenerative disease or trauma, the highly specific characteristics of facial muscles and the specific structures of the cells and tissues required for the proper function cannot be exactly replicated by the body itself. Thus, some form of cartilage and bone tissue engineering is necessary for proper regeneration and function. The use of progenitor cells for this purpose would be very beneficial due to their highly adaptable capabilities, as well as their ability to utilize a high diffusion rate, making them ideal for the specific nature and functions of cartilage and facial muscle tissue. Going along with this, once the progenitor cells are obtained, applying them to a scaffold within the oral cavity in the affected location allows them to adapt to the environment and create cartilage or facial muscle tissue that is specific to the form and function of the area. The principal function of the cartilage and tissue is vascularization, which requires a specific form that allows them to aid the proper flow of bodily functions related to the oral cavity such as oxygen flow and removal of waste. Facial muscle is also very thin, making its reproduction much more possible. Taking all these into consideration, this review aims to highlight and expand upon the primary benefits of the cartilage and facial muscle tissue engineering and regeneration, focusing on how these processes are performed outside of and within the body.

关键词： soft tissue regeneration Cartilage tissue engineering Muscle tissue engineering Facial regeneration

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Decellularized adipose matrix provides an inductive microenvironment for stem cells in tissue regeneration

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World Journal of Stem Cells 2020年第7期12卷 585-603页

作者： Ji-Zhong Yang Li-Hong Qiu Shao-Heng Xiong Juan-Li Dang Xiang-Ke Rong Meng-Meng Hou Kai Wang Zhou Yu Cheng-Gang Yi Department of Plastic Surgery Xijing HospitalFourth Military Medical UniversityXi'an 710032Shaanxi ProvinceChina

Stem cells play a key role in tissue regeneration due to their self-renewal and multidirectional differentiation,which are continuously regulated by signals from the extracellular matrix(ECM)***,the unique biological and physical characteristics of the ECM are important determinants of stem cell *** the acellular ECM of specific tissues and organs(such as the skin,heart,cartilage,and lung)can mimic the natural microenvironment required for stem cell differentiation,the lack of donor sources restricts their *** the rapid development of adipose tissue engineering,decellularized adipose matrix(DAM)has attracted much attention due to its wide range of sources and good regeneration *** for DAM preparation involve various physical,chemical,and biological *** combinations of these methods may have different impacts on the structure and composition of DAM,which in turn interfere with the growth and differentiation of stem *** is a narrative review about *** summarize the methods for decellularizing and sterilizing adipose tissue,and the impact of these methods on the biological and physical properties of *** addition,we also analyze the application of different forms of DAM with or without stem cells in tissue regeneration(such as adipose tissue),repair(such as wounds,cartilage,bone,and nerves),in vitro bionic systems,clinical trials,and other disease research.

关键词： Extracellular matrix Decellularized adipose matrix Decellularized adipose tissue Adipose-derived extracellular matrix Adipose tissue extracellular matrix Adipose matrix Stem cells soft tissue regeneration Decellularization methods

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Implant site development using titanium plate and platelet-rich fibrin for congenitally missed maxillary lateral incisors:A case report

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World Journal of Clinical Cases 2022年第6期10卷 2015-2022页

作者： Tian-Shou Zhang Mahmoud Mudalal Si-Cong Ren Yan-Min Zhou Department of Prosthodontics School and Hospital of StomatologyJilin UniversityChangchun 130021Jilin ProvinceChina Department of Dental Implantology School and Hospital of StomatologyJilin UniversityChangchun 130021Jilin ProvinceChina Department of Oral and Maxillofacial Surgery and Periodontology Faculty of DentistryThe Arab American UniversityJenin 240Palestine

BACKGROUND Bone deficiency and soft tissue atrophy in the absence of maxillary lateral incisors are among the most challenging problems for implant *** bone grafting is the gold standard for bone augmentation,but not without ***-rich fibrin(PRF),a biodegradable autologous biomaterial,has been widely used for bone and soft tissue ***,titanium plate is an advantageous barrier due to its good space-maintaining ***,there is a lack of literature on implant site development using titanium plate and PRF for congenitally missing maxillary lateral *** SUMMARY The patient was a 19-year-old girl with a congenitally missing tooth(#12).She underwent implant placement and simultaneous autologous bone grafting with titanium plate and *** the follow-up visit 15 d post-procedure,the vascularization of soft tissue was *** was no swelling or pain after the *** months postoperatively,bone regeneration was ***,the definitive restoration was placed,and the patient was satisfied with the esthetic *** Implant site development using titanium plate and PRF for congenitally missing maxillary lateral incisors is a feasible *** this case,the labial bone plate was displaced but remained connected to the base bone,ensuring blood *** titanium plate fixed the labial bone plate and maintained the osteogenic space,while the PRF provided growth factors and leukocytes for bone and soft tissue ***,the procedure reduced the surgical complexity and adverse reactions,displaying outstanding esthetic outcomes.

关键词： Implant placement Platelet-rich fibrin Missing incisor Bone augmentation soft tissue regeneration Case report

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