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Significant Phenomena Observed in the Molecule-Ion Adduct System of sodium arsenite with aoCyclodextrin

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Chinese Journal of Chemistry 2011年第4期29卷 679-684页

作者：党政宋乐新杨军杨晶 CAS Key Laboratory of Soft Matter Chemistry University of Science and Technology of China Hefei Anhui 230026 China Department of Chemistry University of Science and Technology of China Hefei Anhui 230026 China

The data of 1H nuclear magnetic resonance and molar conductivity prove that there is a molecule-ion interaction between a-cyclodextrin （a-CD） and sodium arsenite （SA）, and the interaction site is different from that between β-CD and SA. The packing mode of a-CD molecules after adduct with SA is changed from cage to channel type. Several experimental phenomena from thermogravimetric analyses and gas chromatography coupled to time-of-flight mass spectrometry measurements reveal that the presence of SA has led to a large change of thermal decomposition behavior of a-CD, and vice versa. The current work reveals the particularity of the interaction between SA and a-CD, which would provide new insight into the understanding of molecule-ion interactions.

关键词： cyclodextrin adduct sodium arsenite noncovalent interactions

Microcalorimetric Study on the Effect of sodium arsenite on Metabolic Activity of Mitochondria Isolated from Carassius auratus Liver Tissue

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Chinese Journal of Chemistry 2006年第8期24卷 997-1000页

作者：戴捷刘义朱军成张业中 Department of Environmental Engineering College of Chemistry and Environmental Engineering Yangtze University Jingzhou Hubei 434025 China Department of Chemistry College of Chemistry and Molecular Sciences Wuhan University Wuhan Hubei 430072 China

Metabolic thermogenic curves of mitochondria isolated from liver tissue of Carassius auratus and the effect of different concentration of NaAsO2 on it were investigated by TAM air isothermal microcalorimeter, ampoule method, at 28.00 ℃. From the thermogenic curves, activity recovery rate constants k, the maximum heat production rate （Pmax） and the total heat produced （Q） were obtained. The values of k and Pmax decline gradually with the increase of the concentration of NaAsO2, and both of the values of Pmax and k are highly correlated to the concentration of NaAsO2. When concentration of NaAsO2 reached 16.0 μg/mL, the maximum heat production rate dropped to 70.8% of the control group, and the corresponding percentage of k was 71.4% of the control group. This experimental result indicates that the addition of NaAsO2 has restrained the metabolic activities of mitochondria in vitro.

关键词： microcalorimetry thermokinetics sodium arsenite mitochondria

Ameliorating effects of Raphanus sativus leaves on sodium arsenite-induced perturbation of blood indices in Swiss albino mice

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Asian Pacific Journal of Tropical Biomedicine 2017年第10期7卷 915-920页

作者： Sayada Dilruba MMHasibuzzaman Mashiur Rahman Nayan Chandra Mohanto Sharmin Aktar Atiqur Rahman Md Imam Hossain Abu Shadat Mohammod Noman Farjana Nikkon Zahangir Alam Saud Khaled Hossain Department of Biochemistry and Molecular Biology University of RajshahiRajshahi 6205Bangladesh Department of Biochemistry EXIM Bank Agricultural University BangladeshChapainawabganj 6300Bangladesh Department of Biochemistry and Molecular Biology Shahjalal University of Science and TechnologySylhet 3114Bangladesh Department of Biochemistry and Molecular Biology Mawlana Bhashani Science and Technology UniversitySantoshTangail 1902Bangladesh Department of Biotechnology and Genetic Engineering Mawlana Bhashani Science and Technology UniversitySantoshTangail 1902Bangladesh Department of Biochemistry and Molecular Biology University of ChittagongChittagong 4331Bangladesh

Objective: To evaluate the ameliorating effects of Raphanus sativus leaves(RSL)against sodium arsenite(Sa)-induced adverse effects through mice ***: Swiss albino mice were divided into four equal groups: control, Sa, RSL,RSL + Sa. Sa(10 mg/kg body weight/day), and powder form of RSL(50 mg/kg body weight/day) were provided as food supplement orallty. Blood indices were measured using commercially available kits through colorimetric ***: It was observed that lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase activities were significantly(P < 0.05)higher in Sa-treated mice than those in the control group. RSL significantly reduced Sainduced elevation of the activities of these enzymes in serum significantly(P < 0.05).Serum butyrylcholinesterase activity and high density lipoproteins cholesterol levels in Satreated mice were significantly(P < 0.05) lower than the control group, and the food supplementation of RSL could significantly(P < 0.05) prevent the reduction of Sa-mediated serum butyryl cholinesterase activity and high density lipoproteins cholesterol levels. RSL could also reduce the Sa-induced elevation of serum urea level significantly(P < 0.05).Conclusions: Results of this study suggest the protective or ameliorating effects of RSL on Sa-induced perturbation of blood indices are related to the hepatic, cardiovascular and kidney dysfunction. Therefore, RSL may be useful to reduce arsenic toxicity in human in the future.

关键词： sodium arsenite Raphanus sativus leaves Ameliorating effect Serum indices

sodium arsenite and arsenic trioxide differently affect the oxidative stress,genotoxicity and apoptosis in A549 cells:an implication for the paradoxical mechanism

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Sodium arsenite and arsenic trioxide differently affect the ...

大气中NO2浓度的测定方法—sodium arsenite法

第十一届全国博士生学术年会

作者： Xuejun Jiang Zunzhen Zhang Department of Environmental Health West China School of Public HealthSichuan University

Although arsenic toxicity greatly depends on its chemical forms,few studies have taken into account the paradoxical phenomenon which is manifested by that sodium arsenite（NaAsO） acts as a potent carcinogen but arsenic trioxide（AsO） serves as an effective therapeutic *** this study,we compared the in vitro effects of NaAsO and AsO on cell viability,colony formation,cell cycle progression, apoptosis,genotoxicity and oxidative stress in human lung adenocarcinoma A549 *** results demonstrated that both NaAsO and AsO caused oxidative stress, genotoxicity,cytotoxicity,cell cycle arrest as well as apoptosis,while AsO induced higher production of reactive oxygen species（ROS） with a more remarkable decrease in superoxide dismutase（SOD） activities and intracellular levels of glutathione（GSH） than ***,the degree of DNA damage,chromosomal breakage,cell cycle arrest and apoptosis in AsO-treated cells were more severe than those in NaAs02-treated *** findings suggest that differential effects and mechanisms of NaAsO and AsO may responsible for the paradoxical effects of arsenic on the carcinogenesis and anticancer function.

关键词： sodium arsenite Arsenic trioxide Paradoxical effect Oxidative stress Apoptosis Genotoxicity.

来源： cnki会议评论

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煤炭转化 1979年第3期 110-110页

本文报导测定大气中NO浓度的方法之一—sodium arsenite法的测定精度的对比研究结果。对比试样是采用含有50～370μg/m~3NO的城市大气。研究结果表明,当NO浓度在84～312μg/m~3范围内

关键词： sodium arsenite 测定方法 NO2

PUB22 and PUB23 U-box E3 ubiquitin ligases negatively regulate 26S proteasome activity under proteotoxic stress conditions

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Journal of Integrative Plant Biology 2022年第3期64卷 625-631页

作者： Min Yong Ahn Dong Hye Seo Woo Taek Kim Department of Systems Biology Division of Life ScienceYonsei UniversitySeoul 03722Korea Institute of Life Science and Biotechnology Yonsei UniversitySeoul 03722Korea

The mechanism regulating proteasomal activity under proteotoxic stress conditions remains ***,we showed that arsenite-induced proteotoxic stress resulted in upregulation of Arabidopsis homologous PUB22 and PUB23 U-boxE3 ubiquitin ligases and that pub22 pub23 double mutants displayed arsenite-insensitive seed germination and root growth ***22/PUB23 downregulated 26 S proteasome activity by promoting the dissociation of the 19 S regulatory particle from the holo-proteasome complex,resulting in intracellular accumulation of UbG76 VGFP,an artificial substrate of the proteasome complex,and insoluble poly-ubiquitinated *** results suggest that PUB22/PUB23 play a critical role in arsenite-induced proteotoxic stress response via negative regulation of 26 S proteasome integrity.

关键词： Arabidopsis thaliana proteotoxic stress sodium arsenite U-box E3 ligases PUB22/23 26S proteasome complex

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Effects of Some Thiol Chelators on Enzymatic Activities in Blood, Liver and Kidneys ofAcute Arsenic (Ⅲ) Exposed Mice

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Biomedical and Environmental Sciences 1998年第1期11卷 38-45页

作者： NEELIMATRIPATHI S.J.SFLORA DivisionofPharmacologyandToxicology DefenceResearchandDevelopmentEstablishmentGwalior－474002India D

The effects of meso 2, 3-dimercaptosuccinic acid (DMSA), sodium 2, 3 dimercaptopropane 1-sulfonate (DMPS) and S-adenosyl L-methionine (SAM) on the enzymatic activities of mice were studied. The mice were given intraperitoneal (i. p. ) injections of these chelating agents (1 mmol/kg) and 3 h later the activity of 8-aminolevulinic acid dehydratase (ALAD) in the blood, and aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyltranspeptidase (γ-GT), alkaline phosphatase (ALP) in the liver and kidney were determined. The activity of blood ALAD was significantly increased by the administration of DMSA and SAM while DMPS had only a moderate effect. The activities of other hepatic enzymes changed little when the mice were treated with these chelating agents, except for a significant reduction in hepatic ALP activlty following DMPS administration. Arsenic (Ⅲ) administration markedly increased the activities of ALT and ALP in the liver and kidneys. The changes in the enzymatic activities by treatment with arsenic were prevented by injection of DMSA,DMPS and SAM, DMSA being the most effective. These results indicate that DMSA, DMPS and SAM were not toxic to the liver or kidneys of mice and that treatment with DMSA is more effective than DMPS or SAM in protecting mice from acute hepatic or renal toxicity caused by arsenic.

关键词： ADENOSYL-L-METHIONINE LEAD-INTOXICATION MESO-2,3-DIMERCAPTOSUCCINIC ACID 2,3-DIMERCAPTOSUCCINIC ACID THERAPEUTIC EFFICACY sodium arsenite DMSA RATS EXCRETION AGENTS

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蜂胶提取物拮抗砷化物对人体外周血淋巴细胞致突变作用研究

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现代预防医学 2006年第4期33卷 475-476页

作者：王菊香 056029 河北工程学院医学院邯郸

目的:研究蜂胶对亚砷酸钠诱发的体外培养的人体外周血淋巴细胞染色体畸变抑制作用。方法:不同浓度的蜂胶提取物和亚砷酸钠溶液按照不同加入顺序与人体外周血接触培养,观察畸变类型和畸变细胞率。结果:蜂胶和亚砷酸钠分先后与血细胞作用... 详细信息

目的:研究蜂胶对亚砷酸钠诱发的体外培养的人体外周血淋巴细胞染色体畸变抑制作用。方法:不同浓度的蜂胶提取物和亚砷酸钠溶液按照不同加入顺序与人体外周血接触培养,观察畸变类型和畸变细胞率。结果:蜂胶和亚砷酸钠分先后与血细胞作用组,当蜂胶终浓度为20μg/ml及以上时,总畸变细胞率及各类型畸变率低于阳性对照组,差异有统计学意义(P<0·01),蜂胶和亚砷酸钠同时作用组,当蜂胶终浓度为10μg/ml及以上时总畸变细胞率及各类型畸变率低于阳性对照组,差异有统计学意义。结论:蜂胶对亚砷酸钠所致细胞染色体突变有抑制作用,其对突变细胞有分化逆转作用。

关键词： Propolis sodium arsenite Chromosomal aberration Perpheral blood lymphocyte.

MiADMSA minimizes arsenic induced bone degeneration in Sprague Dawley rats

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Emerging Contaminants 2020年第1期6卷 204-211页

作者： Shashikanta Sau K.B.Sathua S.J.S.Flora Division of Pharmacology and Toxicology National Institute of Pharmaceutical Education and ResearchNew Transit CampusBijnor RoadSarojini NagarNear CRPF Base CampLucknowUPIndia

Arsenic considered as one of the most hazardous chemical while arsenic poisoning is also one of the serious medical issues *** term arsenic exposure is associated with bone *** exact mechanism involving arsenic induced bone degeneration remains unclear but,plentiful literature suggested that oxidative/nitrosative stress caused by generation of reactive oxygen species(ROS)and reactive nitrogen species(RNS)is one of the leading *** treatment strategies are available for bone degeneration however,the suitable treatment for arsenic induced bone degeneration still *** the current investigation,we evaluated the efficacy of chelation against arsenic induced bone degeneration in experimental *** Sprague Dawley rats were exposed to sodium arsenite and dimethylarsinic acid(DMA)(50 ppm)for 18 *** arsenic exposure,animals were treated with Monoisoamyl dimercaptosuccinic acid(MiADMSA)for three course of treatment(50 mg/kg,p.o.,once daily for 5 days)with an interval of one week between two courses of *** minimizes the bone degeneration through reduction of oxidative stress(Reactive Oxygen Species,Reactive Nitrogen Species,and thiobarbituric reactive substances),alteration of antioxidant status(rGSH,Superoxide dismutase,Catalase)which led to the depletion in the levels of inflammatory markers like TNFa and IL-1b and alteration in the bone remodelling biomarkers like ALP,RANKL,and *** can be concluded from this study that MiADMSA could be an effective therapeutic strategy against arsenic induced bone degeneration and the possible mechanism could be the chelation of arsenic accompanied by the reduction in oxidative stress and inflammation.

关键词： sodium arsenite Bone degeneration Oxidative/nitrosative stress MiADMSA