检索结果-南通市图书馆

Linolenic acid-metronidazole inhibits the growth of Helicobacter pylori through oxidation

世界胃肠病学杂志:英文版 2023年第32期29卷 4860-4872页

作者： Wen-Ting Zhou Yuan-Yuan Dai Li-Juan Liao Shi-Xian Yang Hao Chen Liang Huang Juan-Li Zhao Yan-Qiang Huang School of Basic Medicine Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina School of Basic Medicine Youjiang Medical University for NationalitiesAffiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Laboratory Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina School of Basic Medicine Department of PathologyWannan Medical CollegeWuhu 533000Anhui ProvinceChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina School of Basic Sciences Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Resistance to antibiotics is one the main factors constraining the treatment and control of Helicobacter pylori(***)***,there is an urgent need to develop new antimicrobial agents to replace *** previous study found that linolenic acid-metronidazole(Lla-Met)has a good antibacterial effect against ***,both antibiotic-resistant and sensitive ***,*** does not develop resistance to ***,it could be used for preparing broad-spectrum antibacterial ***,since the antibacterial mechanism of Lla-Met is not well understood,we explored this phenomenon in the present *** To understand the antimicrobial effect of Lla-Met and how this could be applied in treating corresponding *** *** cells were treated with the Lla-Met compound,and the effect of the compound on the cell morphology,cell membrane permeability,and oxidation of the bacteria cell was ***,the differently expressed genes in *** in response to Lla-Met treatment were *** Lla-Met treatment induced several changes in *** cells,including roughening and *** vivo experiments revealed that Lla-Met induced oxidation,DNA fragmentation,and phosphatidylserine ectropionation in *** *** Lla-Met with L-cysteine abrogated the above *** analysis revealed that Lla-Met treatment up-regulated the expression of superoxide dismutase sodb and MdaB genes,both anti-oxidation-related *** Lla-Met kills *** mainly by inducing oxidative stress,DNA damage,phosphatidylserine ectropionation,and changes on cell morphology.

关键词： Helicobacter pylori Oxidation Superoxide dismutase sodb genes MdaB genes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：