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Density-induced social stress alters oxytocin and vasopressin activities in the brain of a small rodent species

Integrative Zoology 2021年第2期16卷 149-159页

作者： Shuli HUANG Guoliang LI Yongliang PAN Mingjing SONG Jidong ZHAO Xinrong WAN Charles JKREBS Zuoxin WANG Wenxuan HAN Zhibin ZHANG State Key Laboratory of Integrated Pest Management Institute of ZoologyChinese Academy of SciencesBeijingChina CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijingChina School of Medicine Huzhou UniversityHuzhouChina Key Laboratory of Human Disease Comparative Medicine National Health Commission of China(NHC)Beijing Engineering Research Center for Experimental Animal Models of Human DiseasesInstitute of Laboratory Animal SciencePeking Union Medicine CollegeChinese Academy of Medical ScienceBeijingChina Department of Zoology University of British ColumbiaVancouverBritish ColumbiaCanada Department of Psychology and Program in Neuroscience Florida State UniversityTallahasseeFloridaUSA College of Resources and Environmental Sciences China Agricultural UniversityBeijingChina

It is known that social stress could alter oxytocin(OT)and arginine-vasopressin(AVP)expression in specific regions of brains which regulate the aggressive behavior of small rodents,but the effects of density-induced social stress are still unknown.Brandt’s voles(Lasiopodomys brandtii)are small herbivores in the grassland of China,but the underlying neurological mechanism of population regulation is still unknown.We tested the effects of housing density of Brandt’s voles on OT/AVP system with physical contact(allowing aggression)and without physical contact(not allowing aggression)under laboratory conditions.Then,we tested the effects of paired-aggression(no density effect)of Brandt’s voles on OT/AVP system under laboratory conditions.We hypothesized that high density would increase aggression among animals which would then increase AVP but reduce OT in brains of animals.Our results showed that high housing density induced more aggressive behavior.We found high-densityinduced social stress(with or without physical contact)and direct aggression significantly increased expression of mRNA and protein of AVP and its receptor,but decreased expression of mRNA and protein of OT and its receptor in specific brain regions of voles.The results suggest that density-dependent change of OT/AVP systems may play a significant role in the population regulation of small rodents by altering density-dependent aggressive behavior.

关键词： aggression behavior density-dependent stress oxytocin(OT) social stress vasopressin(AVP)

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How social stress and oxytocin influence the way people update their belief?

How social stress and oxytocin influence the way people upda...

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第二十一届全国心理学学术会议

作者： Wenying Yuan Xinyuan Yan Ingrid Huang Di Wu Zhengxuan Li Yina Ma State Key Laboratory of Cognitive Neuroscience and Learning IDG/McGovern Institute for Brain Research Beijing Normal University

stress, a common experience in daily life, has both health risks and benefits. While prolonged stress has been linked with impaired immunity and higher risk for depression and anxiety disorders, stress has been recognized as potentially adaptive in the regulation of our immunity and cognitive performance. social evaluation can serve as social support to protect individuals from stress but can also intensify stress. However, it remains unknown how acute social stress influences the processing of social feedback. Here, combining a two-stage belief update paradigm and a social evaluative stress paradigm, we examine whether and how acute social stress and intranasal administration of oxytocin influence individual’s belief update upon desirable and undesirable social feedback. We found that participants’ heart rate and cortisol level were significantly increased after experiencing stress. Moreover, oxytocin decreased participants’ cortisol response to social stress. We further showed that oxytocin administration under stress led to the most optimistic-oriented belief updating pattern, suggesting an interactive effect of social stress and oxytocin on optimistic beliefs. Moreover, this interactive effect was mainly found for belief updating selectively upon desirable feedback but not upon undesirable feedback. social stress and oxytocin treatment facilitate optimistic belief updating. Supporting the protective hypothesis, individuals experiencing and given oxytocin treatment exhibit the highest level of optimism.

关键词： Oxytocin social stress Belief update optimism

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A short note on how tied fights affect cortisol levels

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Integrative Zoology 2013年第3期8卷 324-326页

作者： Edwin L.COOPER Kathy T.NGO Department of Neurobiology University of CaliforniaLos AngelesCAUSA Department of Molecular Cell and Developmental BiologyUniversity of CaliforniaLos AngelesCAUSA

Previous work exploring the interrelationships between sex steroids(e.***.androgens,testosterones and 11-ketotestosterones)and social behavior in teleosts suggest that mirror-elicited aggression in cichlid fish may not trigger a hormonal response.Using the Mozambique tilapia(Oreochromis mossambicus)to analyze immune responses as a result of social stress,we measured levels of cortisol and melatonin using Enzyme-Linked Immunosorbent Assay(ELISA)assays.In this work,we demonstrated that cortisol concentrations are significantly lower yet the levels of melatonin remain unchanged in tilapia that are fighting their mirror image.Our results suggested that in tied fights,certain hormone levels remain unchanged(e.***.androgens)due to the lack of melatonin induction.

关键词： cortisol hormone level melatonin social stress tilapia

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Opposite Sex Contact and Isolation: A Novel Depression/Anxiety Model

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Neuroscience Bulletin 2016年第1期32卷 92-98页

作者： Liu Yang Li-Jun Shi Bei Tang Qiu-Qin Han Jin Yu Gen-Cheng Wu Yu-Qiu Zhang Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Institute of Neurobiology Institutes of Brain Science and State Key Laboratory of Medical NeurobiologyCollaborative Innovation Center for Brain Science Liver Cancer Institute Zhongshan Hospital Shanghai Medical College Fudan University Department of Integrative Medicine and Neurobiology Shanghai Medical College Fudan University

To mimic human mood disorders, traditional chronic stresses and social defeat stress have been developed and widely applied. However, these active stresses do not mimic the emotional flaws induced by stresses, and their input levels vary greatly. Also, emotional stresses resulting from social unobtainability remain largely elusive due to the lack of useful animal models. In this study, we developed a mouse model named ‘‘opposite sex contact and isolation’’(OSCI) and found that OSCI induced significant social avoidance, anhedonia, and anxiety. These behavioral defects developed differently after 7 days of OSCI. The social avoidance behavior was self-curable while anxiety gradually worsened but was alleviated by re-pairing with the same female partner. Corresponding to the behavior changes, the plasma corticosterone and phosphorylated c AMP response element binding protein levels were decreased in the nucleus accumbens of the mice that experienced isolation. Together,this study has developed a novel strategy for depression/anxiety modeling and shows that OSCI may be a useful tool for studying the lovelorn/lovesick type of depression.

关键词： social isolation Depression Anxiety Opposite sex contact social stress Lovelorn

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