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World Journal of Psychiatry 2025年第1期15卷 137-144页

作者： Juan Fang Li-Hui Li Ming-Qian He Yue Ji Dong-Yan Lu Li-Bing Zhang Jin-Lan Yao School of Medicine Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Frailty has become a significant public health *** recent increase in the number of frail older adults has led to increased attention being paid to psycho-logical care services in *** social isolation of pre-frail older adults can impact their psychological *** To explore the mediating effect of health literacy between social isolation and psychological distress among communitydwelling older adults with *** This descriptive cross-sectional study was conducted with 254 pre-frail older individuals aged 60 years and *** isolation,health literacy,and psycholo-gical distress were comprehensively measured using the Lubben social Network Scale-6,12-item Short-Form Health Literacy Questionnaire,and the Kessler Psy-chological Distress *** were evaluated using the SPSS 27.0 package program and the PROCESS macro *** statistical analyses,correlation analyses,and bootstrap mediation tests were used to assess associations between the *** The results showed that social isolation had an effect on health literacy among pre-frail older adults(β=0.240,Psocial isolation impact on psycho-logical distress pre-frail older adults(β=-0.415,Psocial isolation and psychological distress among community-dwelling older adults with pre-frailty,with a mediation effect of-0.074,accounting for 17.83%of the total effect.

关键词： Frail Ageing Psychological distress Health literacy social isolation

social isolation in Male Rats During Adolescence Inhibits the Wnt/β-Catenin Pathway in the Prefrontal Cortex and Enhances Anxiety and Cocaine-Induced Plasticity in Adulthood

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Neuroscience Bulletin 2020年第6期36卷 611-624页

作者： Santiago Cuesta Alejandrina Funes Alejandra M.Pacchioni Area Toxicologia Departamento de Ciencias de los Alimentos y del MedioambienteFacultad de Ciencias Bioquimicas y FarmaceuticasUniversidad Nacional de RosarioSuipacha 5312000 RosarioSanta FeArgentina Consejo Nacional de Investigaciones Cientificas y Tecnicas RosarioArgentina Present Address:Department of Microbiology University of Texas Southwestern Medical CenterDallasTX 75390USA

In adult animals,it is well established that stress has a proactive effect on psychostimulant ***,whether only a short period of stress during adolescence can also affect cocaine responses later in life and what mechanisms are involved are ***,we showed that 5 days of social isolation during rat adolescence had a long-term impact on anxiety-like behaviors,cocaine-induced conditioned place preference,and the expression of sensitization during *** the molecular level,social isolation decreased the activity of the Wnt/β-catenin pathway in the prefrontal cortex(PFC).Furthermore,after the expression of cocaine sensitization,isolated rats showed an increase in this pathway in the nucleus ***,these findings suggest that,adolescent social isolation by altering the Wnt/β-catenin pathway in the developing PFC might increase the cocaine responses during adulthood,introducing this pathway as a novel neuroadaptation in the cortical-accumbens connection that may mediate a stress-induced increase in vulnerability to drugs.

关键词： social isolation Adolescence Cocaine vulnerability Wnt/(i-catenin pathway

social isolation and loneliness among older adults in the context of COVID-19:a global challenge

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Global Health Research and Policy 2020年第1期5卷 210-212页

作者： Bei Wu NYU Aging Incubator and Hartford Institute for Geriatric Nursing 433 First Ave5th FloorNew YorkNY 10010USA

We are experiencing a historical moment with an unprecedented challenge of the COVID-19 global *** outbreak of COVID-19 will have a long-term and profound impact on older adults’health and *** isolation and loneliness are likely to be one of the most affected health *** isolation and loneliness are major risk factors that have been linked with poor physical and mental health *** paper discusses several approaches that may address the issues of social isolation and *** approaches include promoting social connection as public health messaging,mobilizing the resources from family members,community-based networks and resources,developing innovative technology-based interventions to improve social connections,and engaging the health care system to begin the process of developing methods to identify social isolation and loneliness in health care settings.

关键词： COVID-19 social isolation Aging Public health messaging

Association between COVID-19 and anxiety during social isolation:A systematic review

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World Journal of Clinical Cases 2021年第25期9卷 7433-7444页

作者： Erlene Roberta Ribeiro dos Santos Jose Lucas Silva de Paula Felipe Maia Tardieux Vânia NazaréCosta-e-Silva Amos Lal Antonio Flaudiano Bem Leite Department of Neuropsychiatry and Behavioral Science-Neurosciences Research Circle on TechnologiesStrategies and Instruments Applied to Collective HealthVitória de Santo Antão 55608680Brazil Department of Collective Health Research Circle on TechnologiesStrategies and Instruments Applied to Collective HealthVitória de Santo Antão 55608680Brazil State Audit Component of the Unified Health System State Health SecretariatRecife 50751530Brazil Department of Medicine Division of Pulmonary and Critical Care MedicineMayo ClinicRochesterMN 55905United States Department of Epidemiological Surveillance Henrique de HolandaMunicipal Health SecretariatVitória de Santo Antão 55608680Brazil

BACKGROUND The uncertainties about coronavirus disease 2019(COVID-19),the change in routine,lifestyles and the reduction of physical contact can cause stress,anxiety,emotional overload,poor sleep and even physical health *** To evaluate the scientific publications available on the relationship between COVID-19 and anxiety experienced in the general population,during the period of social isolation,adopted by governmental organizations and public health policymakers as a measure to contain the spread of *** A literature search was performed systematically exploring the PubMed and Medline databases using the following terms classified as MeSH descriptors:(“anxiety”AND“pandemic”AND“COVID-19”).For the search,in the Biblioteca Virtual em Saúde–BVS,***,Web of Science and National Library plat forms, the following keywords were used: ("anxiety" AND "coronavirus" AND"social isolation"). Thirty-seven peer-reviewed articles were found. PRISMA andthe Downs & Black checklist were used for qualitative *** applying the inclusion criteria, seven (n = 7) original scientific articles wereselected. The collated evidence demonstrated increased levels of symptoms ofanxiety and depression during the period of social isolation. The populationbetween 21 to 40 years was most affected. The risk of severe depression was twiceas high at the epicenter of the pandemic. Sleep quality was significantly *** about politics, religion, and consumption of products from China werefound to generate fear and anticipate probable changes in the pattern of postpandemicconsumption. social isolation exacerbated feelings of extreme hopelessness,sadness, loneliness and suicidal *** conclude that there is a potential relationship between social isolation duringthe COVID-19 pandemic and symptoms of anxiety. It is important to note that thedirect and indirect costs of not identifying the detrimental effects of thisphenomenon and ne

关键词： Pandemic COVID-19 Anxiety social isolation Mental health Public health

Impact of social isolation and resident intruder stress on aggressive behavior in the male rat

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Neural Regeneration Research 2010年第15期5卷 1175-1179页

作者： Sheng Wei Huiyun Zhang Jie Gao Ling Xue Peng Sun Yubin Chao Gang Xue Mingqi Qiao Key Laboratory of Classic Theories on Traditional Chinese Medicine Shandong University of Traditional Chinese Medicine Ministry of Education Jinan 250355 Shandong Province China

Stress studies frequently utilize physical stressors to establish animal models of stress. In the majority of cases, these models are not consistent with human circumstances. The present study simulated a social isolation plus resident intruder stress model in the rat. The rats were subjected to daily social isolation and resident intruder stress for 2 weeks. Behaviors were then tested. Rats subjected to social stress exhibited different aggressive behavior styles; some rats had greater scores on composite aggression behaviors, as well as locomotor and exploratory activity, but lower scores on latency than others. The high-aggressive group exhibited predominantly anger-out, while the low-aggressive group exhibited anger-in. Results suggest that social isolation plus resident intruder may serve as an appropriate model for anger-in and anger-out emotion modeling in the rat.

关键词： aggressive behavior test social isolation resident intruder stress rat model anger-out/anger-in

Moderating Mechanism in the Relationship between social isolation and Mental Health among College Students during High-Risk Period of COVID-19 Transmission in Hubei, China

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International Journal of Mental Health Promotion 2023年第2期25卷 193-206页

作者： Dong Yang Chia Ching Tu Zhengyan Guo Xiao Dai Chia Feng Tu International College Krirk UniversityBangkok10220Thailand Chinese International College Dhurakij Pundit UniversityBangkok10210Thailand Wei Gong Memorial Hospital Toufen CityMiaoli County351011Taiwan

This study explored the effect of perceived social isolation on the mental health of college students during the high-risk period of COVID-19 transmission in Hubei,China and the role of social support from online friends in alleviating this *** questionnaire responses of 213 college students from four universities in Hubei were *** and structural models were constructed using structural equation *** findings revealed that perceived social isolation while under home quarantine was a negative predictor of the mental health of college students in *** social support from online friends may lead to a relatively strong relationship between perceived social isolation and mental health in these college students,whereas high social support from online friends may lead to a relatively weak relationship between perceived social isolation and mental health.

关键词： social isolation social support mental health moderator Hubei

social isolation and health-promoting behaviors among older adults living with different health statuses:A cross-sectional study

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International Journal of Nursing Sciences 2021年第3期8卷 304-309,I0005页

作者： Fan Wu Yu Sheng College of Medicine and Health Science Wuhan Polytechnic UniversityHubeiChina School of Nursing Peking Union Medical CollegeBeijingChina

Objectives:To describe the characteristics and relationships of social isolation and health promoting behaviors of Chinese older adults with different health ***:Totally 485 older adults were *** were divided into three groups based on their health status:healthy group(n=72),group with one disease(n=183)and group with multimorbidity(n=230).Lubben social Network Scale-6 and Health-Promoting Lifestyle Profile II were used to measure their social isolation and health-promoting behaviors,***:Among the aged with one disease or multimorbidity,30.6%(56/183)and 31.7%(73/230)were socially isolated,respectively,based on the score of the Lubben social Network *** three groups differed significantly in health-promoting behaviors and scores on several *** group with multimorbidity exhibited more social isolation and fewer health-promoting behaviors than other *** isolation was among the factors adversely affecting health-promoting behaviors in older ***:Health care providers should help older adults with multimorbidity preserve the remaining abilities to improve health-promoting ***,it is important to support healthy older adults to increase self-responsibility to achieve healthy aging.

关键词： Aged China Healthy aging Health status Multimorbidity Healthy lifestyle social isolation

Adolescent social isolation influences cognitive function in adult rats

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Neural Regeneration Research 2013年第11期8卷 1025-1030页

作者： Feng Shao Xiao Han Shuang Shao Weiwen Wang Department of Psychology Peking University Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences

Adolescence is a critical period for neurodevelopment. Evidence from animal studies suggests that isolated rearing can exert negative effects on behavioral and brain development. The present study aimed to investigate the effects of adolescent social isolation on latent inhibition and brain-derived neurotrophic factor levels in the forebrain of adult rats. Male Wistar rats were randomly divided into adolescent isolation （isolated housing, 38-51 days of age） and social groups. Latent inhibition was tested at adulthood. Brain-derived neurotrophic factor levels were measured in the medial prefrontal cortex and nucleus accumbens by an enzyme-linked immunosorbent assay. Adolescent social isolation impaired latent inhibition and increased brain-derived neurotrophic factor levels in the medial prefrontal cortex of young adult rats. These data suggest that adolescent social isolation has a profound effect on cognitive function and neurotrophin levels in adult rats and may be used as an animal model of neurodevelopmental disorders.

关键词： neural regeneration adolescence social isolation latent inhibition brain-derived neurotrophicfactor medial prefrontal cortex nucleus accumbens adult cognitive function neurodevelopmentaldisorders grants-supported paper neuroregeneration

Analysis of the Current Situation and Influencing Factors of social isolation Among the Elderly in the Community

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Proceedings of Anticancer Research 2024年第3期8卷 150-156页

作者： Weiwei Dong Xiaohui Qi Jialiang Wang Dongmei Cui Yanling Li Shaohua Li Physical Examination Center Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Departement of Respiratory and Critical Care Medicine Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Neurosurgery Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Departement of Nursing Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Departement of Neonatology Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

Objective: To investigate the current situation of social isolation among the elderly in the community, and to analyze its influencing factors. Methods: A total of 265 elderly people were selected to conduct the survey using the general information questionnaire and the Chinese version of the social isolation scale for the elderly. Results: The social isolation score of the elderly was (20.15 ± 0.23). Factors such as age, education level, economic status, and social participation ability influenced the social isolation score (P social isolation of the elderly is more serious, and the social isolation can be alleviated by improving the level of education and the economic situation and strengthening social participation.

关键词： Community Elderly social isolation

The Relationship Between social isolation and Psychological Well-Being Among Older Adults in the Community

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Journal of Clinical and Nursing Research 2024年第9期8卷 183-190页

作者： Weihua Liu Yanling Li Xiaoxing Wang Lijing Yan Fengwan Wang Ying Wang Surgical Comprehensive Ward Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Nursing Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Respiratory and Critical Care Medicine Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Department of Integrated Traditional Chinese and Western Medicine Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina

Objective:To investigate the psychological well-being of the elderly in Baoding City,Hebei Province,and analyze its influencing factors,with a focus on exploring the relationship between social isolation and psychological *** study aims to provide a reference for effective interventions that promote the physical and mental health of elderly individuals in the ***:A total of 265 elderly individuals from six communities in Baoding City,Hebei Province were surveyed between November 2023 and March 2024 using the general information questionnaire,the social isolation Scale for the Elderly,and the Comprehensive Happiness ***:The total score of the social isolation Scale for the elderly in the community was(14.15±3.73)points,indicating a moderate level of social *** average score of P50 on the Psychological Well-being Scale was 4.88,suggesting that the psychological well-being of the elderly in the community was moderate to *** regression analysis showed that the level of social isolation significantly influenced the psychological well-being of the elderly(Psocial isolation negatively correlated with psychological ***:Healthcare professionals should pay attention to the social isolation of elderly individuals in the community and develop targeted interventions to improve their psychological well-being and quality of life.

关键词： Elderly in the community social isolation Psychological well-being