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Acupuncture for olfactory dysfunction in infected COVID-19 patients:Study protocol for a randomized,sham-controlled clinical trial

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 118-124页

作者： Linda Lidan Zhong Yiping Wong Choryin Leung Chifung Choy Hungwai Cho Alan Yatlun Wong Kaming Yau Rowena Howwan Wong Bacon Fungleung Ng Zhaoxiang Bian School of Chinese Medicine Hong Kong Baptist UniversityHong Kong 999077China Tseung Kwan O Hospital Hong Kong Hospital AuthorityHong Kong 999077China Department of Ear Nose and Throat(ENT)Tseung Kwan O HospitalHong Kong 999077China Haven of Hope Chinese University of Hong Kong Chinese Medicine Clinic Cum Training and Research Centre(Sai Kung District)Hong Kong 999077China Chinese Medicine Department Hong Kong Hospital AuthorityHong Kong 999077China

Background:Olfactory dysfunction(OD)is a common symptom of Corona Virus Disease 2019(COVID-19).It is defined as the reduced or distorted ability to smell during sniffing(orthonasal olfaction)and represents one of the early symptoms in the clinical course of COVID-19 infection.A large online questionnaire-based survey has shown that some post-COVID-19 patients had no improvement 1 month after discharge from the ***:To explore the efficacy of acupuncture for OD in COVID-19 infected patients and to determine whether acupuncture could have benefits over sham acupuncture for OD in post-COVID-19 ***:This is a single-blind,randomized controlled,cross-over *** plan to recruit 40 post-COVID-19 patients with smell loss or smell distortions lasting for more than 1 *** patients will be randomly allocated to the intervention group(real acupuncture)or the control group(sham acupuncture)at a 1:1 *** patient will receive 8 sessions of treatment over 4 weeks(Cycle 1)and a 2-week *** the follow-up,the control group will be subjected to real acupuncture for another 4 weeks(Cycle 2),and the real acupuncture group will undergo the 4-week sham *** primary outcomes will be the score changes on the questionnaire of olfactory functioning and olfaction-related quality of life at week 6,8,12,and 14 from the *** secondary outcomes will be the changes in the olfactory test score at week 6 and 12 from the baseline measured by using the Traditional Chinese version of the University of Pennsylvania smell Identification Test(UPSIT-TC).Discussion:The results of this trial will help to determine the effectiveness of acupuncture for OD in post-COVID-19 *** may provide a new treatment option for patients.

关键词： Olfactory dysfunction smell loss smell distortions COVID-19 Acupuncture Chinese medicine UPSIT

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