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smart drug delivery systems to overcome drug resistance in cancer immunotherapy

Cancer Biology & Medicine 2023年第4期20卷 248-267页

作者： Wenzhe Yi Dan Yan Dangge Wang Yaping Li State Key Laboratory of drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Department of Pharmaceutics School of PharmacyNanjing Medical UniversityNanjing 211116China Yantai Key Laboratory of Nanomedicine&Advanced Preparations Yantai Institute of Materia MedicaYantai 264000China Shandong Laboratory of Yantai drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264000China

Cancer immunotherapy,a therapeutic approach that inhibits tumors by activating or strengthening anti-tumor immunity,is currently an important clinical strategy for cancer treatment;however,tumors can develop drug resistance to immune surveillance,resulting in poor response rates and low therapeutic efficacy.In addition,changes in genes and signaling pathways in tumor cells prevent susceptibility to immunotherapeutic agents.Furthermore,tumors create an immunosuppressive microenvironment via immunosuppressive cells and secrete molecules that hinder immune cell and immune modulator infiltration or induce immune cell malfunction.To address these challenges,smart drug delivery systems(SDDSs)have been developed to overcome tumor cell resistance to immunomodulators,restore or boost immune cell activity,and magnify immune responses.To combat resistance to small molecules and monoclonal antibodies,SDDSs are used to co-deliver numerous therapeutic agents to tumor cells or immunosuppressive cells,thus increasing the drug concentration at the target site and improving efficacy.Herein,we discuss how SDDSs overcome drug resistance during cancer immunotherapy,with a focus on recent SDDS advances in thwarting drug resistance in immunotherapy by combining immunogenic cell death with immunotherapy and reversing the tumor immunosuppressive microenvironment.SDDSs that modulate the interferon signaling pathway and improve the efficacy of cell therapies are also presented.Finally,we discuss potential future SDDS perspectives in overcoming drug resistance in cancer immunotherapy.We believe that this review will contribute to the rational design of SDDSs and development of novel techniques to overcome immunotherapy resistance.

关键词： Cancer immunotherapy drug resistance smart drug delivery system immunosuppressive microenvironment immune cell

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smart stimuli-responsive drug delivery systems in spotlight of COVID-19

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Asian Journal of Pharmaceutical Sciences 2023年第6期18卷 73-99页

作者： Zeinab Najjari Farzaneh Sadri Jaleh Varshosaz Novel drug delivery systems Research Center Department of PharmaceuticsSchool of Pharmacy and Pharmaceutical SciencesIsfahan University of Medical SciencesIsfahanIran

The world has been dealing with a novel severe acute respiratory syndrome(SARS-CoV-2)since the end of 2019,which threatens the lives of many peopleworldwide.COVID-19 causes respiratory infection with different symptoms,from sneezing and coughing to pneumonia and sometimes gastric symptoms.Researchers worldwide are actively developing novel drug delivery systems(DDSs),such as stimuli-responsive DDSs.The ability of these carriers to respond to external/internal and even multiple stimuli is essential in creating“smart”DDS that can effectively control dosage,sustained release,individual variations,and targeted delivery.To conduct a comprehensive literature survey for this article,the terms“Stimuli-responsive”,“COVID-19”and“drug delivery”were searched on databases/search engines like“Google Scholar”,“NCBI”,“PubMed”,and“Science Direct”.Many different types of DDSs have been proposed,including those responsive to various exogenous(light,heat,ultrasound andmagnetic field)or endogenous(microenvironmental changes in pH,ROS and enzymes)stimuli.Despite significant progress in DDS research,several challenging issues must be addressed to fill the gaps in the literature.Therefore,this study reviews the drug release mechanisms and applications of endogenous/exogenous stimuli-responsive DDSs while also exploring their potential with respect to COVID-19.

关键词： Stimuli-responsive smart drug delivery system Biomedical applications Endogenous and exogenous stimuli COVID-19

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Recent advances of two-dimensional materials in smart drug delivery nanosystems

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Bioactive Materials 2020年第4期5卷 1071-1086页

作者： Hua Zhang Taojian Fan Wen Chen Yingchun Li Bing Wang Key Laboratory of Xinjiang Phytomedicine Resources and Utilization of Ministry of Education School of PharmacyShihezi UniversityShihezi832000China Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics Collaborative Innovation Center for Optoelectronic Science&TechnologyInternational Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationShenzhen UniversityShenzhen518060China

smart drug delivery nano-systems show significant changes in their physical or chemical properties in response to slight change in environmental physical and/or chemical signals,and further releasing drugs adjusted to the progression of the disease at the right target and rate intelligently.Two-dimensional materials possess dramatic status extend all over various scientific and technological disciplines by reason of their exceptional unique properties in application of smart drug delivery nano-systems.In this review,we summarized current progress to highlight various kinds of two-dimensional materials drug carriers which are widely explored in smart drug delivery systems as well as classification of stimuli responsive two-dimensional materials and the advantages and disadvantages of their applications.Consequently,we anticipate that this review might inspire the development of new two-dimensional materials with smart drug delivery systems,and deepen researchers’understanding of smart nano-carries based on two-dimensional materials.

关键词： Two-dimensional materials smart drug delivery system Nano-carriers Disease

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