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small noncoding rnas play superior roles in maintaining hematopoietic stem cell homeostasis

Blood Science 2022年第3期4卷 125-132页

作者： Hui Wang Wenchang Qian Yingli Han Pengxu Qian Center of Stem Cell and Regenerative Medicine and Bone Marrow Transplantation Center of the First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Liangzhu Laboratory Zhejiang University Medical CenterHangzhouChina Institute of Hematology Zhejiang University and Zhejiang Engineering Laboratory for Stem Cell and ImmunotherapyHangzhouChina

The maintenance of the mammalian blood system depends on hematopoietic stem cells(HSCs),which are a rare class of adult stem cells with self-renewal and multilineage differentiation *** homeostasis of hematopoietic stem cells is finely tuned by a variety of endogenous and exogenous regulatory factors,and disrupted balance will lead to hematological diseases including leukemia and ***,emerging studies have illustrated the cellular and molecular mechanisms underlying the regulation of HSC ***,the rapid development of second-generation sequencing technologies has uncovered that many small noncoding rnas(ncrnas)are highly expressed in HSCs,including snornas,mirnas,tsrnas,circular rnas,*** this study,we will summarize the essential roles and regulatory mechanisms of these small ncrnas in maintaining HSC ***,this review provides up-to-date information in the regulation of HSC homeostasis by small ncrnas,which sheds light into the development of therapeutic strategies against hematopoietic malignancies.

关键词： Hematopoietic stem cell Homeostasis Self-renewal small noncoding rnas

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Paternal environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational epigenetic inheritance of multiple diseases

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Frontiers of Medicine 2022年第2期16卷 176-184页

作者： Xin Yin Azhar Anwar Yanbo Wang Huanhuan Hu Gaoli Liang Chenyu Zhang Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy State Key Laboratory of Pharmaceutical Biotechnology and Department of PhysiologyJiangsu Engineering Research Center for MicroRNA Biology and BiotechnologyNJU Advanced Institute of Life Sciences(NAILS)School of Life SciencesNanjing UniversityNanjing 210023China

Studies of human and mammalian have revealed that environmental exposure can affect paternal health conditions as well as those of the ***,studies that explore the mechanisms that meditate this transmission are ***,small noncoding rnas(sncrnas)in sperm have seemed crucial to this transmission due to their alteration in sperm in response to environmental exposure,and the methodology of microinjection of isolated total RNA or sncrnas or synthetically identified sncrnas gradually lifted the veil of sncRNA regulation during intergenerational inheritance along the male ***,by reviewing relevant literature,this study intends to answer the following research concepts:(1)paternal environmental factors that can be passed on to offspring and are attributed to spermatozoal sncrnas,(2)potential role of paternal spermatozoal sncrnas during the intergenerational inheritance process,and(3)the potential mechanism by which spermatozoal sncrnas meditate intergenerational *** summary,increased attention highlights the hidden wonder of spermatozoal sncrnas during intergenerational ***,in the future,more studies should focus on the origin of RNA alteration,the target of RNA regulation,and how sncRNA regulation during embryonic development can be sustained even in adult offspring.

关键词： small noncoding rnas epigenetic inheritance paternal intergenerational inherence extracellular vesicles

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