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Effects of psychological stress on small intestinal motility and bacteria and mucosa in mice

World Journal of Gastroenterology 2005年第13期11卷 2016-2021页

作者： Shao-XuanWang Wan-ChunWu DepartmentofGastroenterology YijishanHospitalWuhu241001AnhuiProvinceChina

AIM: To investigate the effects of psychological stress on small intestinal motility and bacteria and mucosa in mice, and to explore the relationship between small intestinal dysfunction and small intestinal motility and bacteria and mucosa under psychological stress. METHODS: Sixty mice were randomly divided into psychological stress group and control group. Each group were subdivided into small intestinal motility group (n= 10), bacteria group (n = 10), and D-xylose administered to stomach group (n= 10). An animal model with psychological stress was established housing the mice with a hungry cat in separate layers of a two-layer cage. A semi-solid colored marker (carbon-ink) was used for monitoring small intestinal transit. The proximal small intestine was harvested under sterile condition and processed for quantitation for aerobes (Escherichia coli) and anaerobes (Lactobacilli). The quantitation of bacteria was expressed as Iog10(colony forming units/g). D-xylose levels in plasma were measured for estimating trie damage of small intestinal mucosa. RESULTS: small intestinal transit was inhibited (39.80±9.50% vs 58.79±11.47%,Psmall intestinal flora (1.78±0.30 log10(CFU/g) vs 1.37±0.21 log10(CFU/g), P0.05). D-xylose concentrations in plasma in psychological stress mice were significantly higher than those in the control group (2.90±0.89 mmol/L vs 0.97±0.33 mmol/L, Psmall intestinal dysfunction under psychological stress may be related to the small intestinal

关键词： Psychological stress small intestinal motility small intestinal bacteria small intestinal mucosa

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small intestinal bacteria overgrowth decreases small intestinalmotility in the NASH rats

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World Journal of Gastroenterology 2008年第2期14卷 313-317页

作者： Wan-Chun Wu Wei Zhao Sheng Li Department of Gastroenterology Yijishan Hospital Wuhu 241000 Anhui ProvinceChina

AIM: To explore the relationship between small intestinalmotility and small intestinal bacteria overgrowth(SIBO) in Nonalcoholic steatohepatitis (NASH), andto investigate the effect of SIBO on the pathogenesisof NASH in rats. The effect of cidomycin in alleviatingseverity of NASH is also studied. METHODS: Forty eight rats were randomly dividedinto NASH group (n = 16), cidomycin group (n = 16)and control group (n = 16). Then each group weresubdivided into small intestinal motility group (n = 8),bacteria group (n = 8) respectively. A semi-solid coloredmarker was used for monitoring small intestinal *** proximal small intestine was harvested under sterilecondition and processed for quantitation for aerobes(E. coli) and anaerobes (Lactobacilli). Liver pathologicscore was calculated to qualify the severity of *** ALT, AST levels were detected to evaluate theseverity of hepatitis. RESULTS: small intestinal transit was inhibited inNASH group (P small intestine transit rate than rats in NASHgroup (P small intestinal florain NASH group than in control group (1.70 ± 0.12 log10(CFU/g) vs 1.28 ± 0.07 log10 (CFU/g), P small intestinalmovement in NASH rats. SIBO may be an importantpathogenesis of Nash. And treatment with cidomycin by mouth can alleviate the severity of NASH.

关键词： Nonalcoholic steatohepatitis small intestinal motility small intestinal bacteria overgrowth treatment

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