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Acupotomy ameliorates subchondral bone absorption and mechanical properties in rabbits with knee osteoarthritis by regulating bone morphogenetic protein 2-smad1 pathway

引用

Journal of Traditional Chinese Medicine 2023年第4期43卷 734-743页

作者： Chen Xilin GUO Yan LU Juan QIN Luxue HU Tingyao ZENG Xin WANG Xinyue ZHANG Anran ZHUANG Yuxin ZHONG Honggang GUO Changqing School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 100029China Acupuncture and Moxibustion Department Beijing Hospital of Traditional Chinese Medicine affiliated with Capital Medical UniversityBeijing 100010China Shenzhen Hospital of Southern Medical University Shenzhen 518000China Institute of Bone Injury China Academy of Chinese Medical SciencesBeijing 100010China

OBJECTIVE:To investigate the effects of acupotomy on the subchondral bone absorption and mechanical properties in rabbits with knee osteoarthritis(KOA).METHODS:The rabbits were divided into blank control,model,acupotomy and electroacupuncture(EA)groups,with 12 rabbits in *** Videman's method was used to prepare KOA *** acupotomy and EA group were given indicated intervention for 3 *** behavior of rabbits in each group was ***,cartilage–subchondral bone units were obtained and morphological changes were observed by optical microscope and micro computed *** test was used to detect the mechanical properties of subchondral bone,Western blot and real-time polymerase chain reaction(RT-PCR)were applied to detect the expression of bone morphogenetic protein 2-smad1(BMP2-smad1)pathway in subchondral ***:Compared with the control group,rabbits in the KOA group showed lameness,knee pain,and cartilage degradation;the subchondral bone showed active resorption,the mechanical properties decreased significantly and the BMP2-smad1 pathway downregulated *** acupotomy and EA intervention could increase the thickness of trabecular bone(***),the bone volume fraction(BV/TV)and the thickness of subchondral bone plate,reduce the separation of trabecular bone(***),improve the maximum load and elastic modulus of subchondral bone,and effectively delay cartilage degeneration in KOA *** process may be achieved through upregulation the related proteins of BMP2-smad1 *** maximum load and elastic modulus of subchondral bone in the acupotomy group were slightly better than those in the EA ***:Acupotomy could effectively protect cartilage by inhibiting abnormal bone resorption and improving mechanical properties of subchondral bone thorough the related proteins of BMP2-smad1 pathway in KOA rabbits.

关键词： acupuncture therapy osteoarthritis knee subchondral bone mechanical properties bone morphogenetic protein 2 smad1 protein

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