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Effectiveness of Xiaoyao capsule(逍遥丸)on sleep disorders and mood disturbance in patients in recovery from coronavirus disease 2019:a randomized controlled trial

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Journal of Traditional Chinese Medicine 2023年第2期43卷 343-351页

作者： YANG Cunqing LIAN Fengmei YANG Guiping HUANG Yufeng ZHANG Shuangbin WANG Jianghua ZHOU Jing GUO Dongqing SHEN Chuanyun YE Tiansong FU Aojie LI Xiaoli CHEN Le ZHANG Huifeng TU Qiyin WANG Ying YANG Wenzhe TONG Xiaolin BA Yuanming Department of Endocrinology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Department of Gastroenterology Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Party Committee Office of Xiaogan Hospital of Traditional Chinese Medicine Xiaogan 432100China Department of Nephrology Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Department of internal Medicine Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Liver Disease Branch Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Department of massage Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Department of Medicine Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Department of internal Medicine Dawu County Hospital of Traditional Chinese MedicineXiaogan 432800China Department of Pulmonary Diseases Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Pharmaceutical Preparation Section Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Acupuncture and Moxibustion Deparment Xiaogan Hospital of Traditional Chinese MedicineXiaogan 432100China Institute of Metabolic Diseases Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Department of nephropathy Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061China

OBJECTIVE:To study the efficacy of Xiaoyao capsule(逍遥丸)in improving the clinical symptoms of sleep and mood disorders during recovery from coronavirus disease 2019(COVID-19).METHODS:The study cohort comprised 200 patients with sleep and mood disorders during recovery from *** were randomized into the control group and the experimental group in a 1:1 ratio by blocked *** patients received either Xiaoyao capsule(experimental group)or a placebo Xiaoyao capsule(control group)for 2 *** improvements in the Traditional Chinese Medicine(TCM)syndrome scales,total effective rates,and disappearance rates of irritability,anxiety,and poor sleep were compared between the two ***:The TCM syndrome pattern scales,total effective rates,and disappearance rates of irritability,anxiety,and poor sleep did not significantly differ between the experimental group versus the control group in the full analysis set and the per protocol set after 1 and 2 weeks of treatment(P>0.05).CONCLUSIONS:Xiaoyao capsule do not significantly improve the clinical symptoms of sleep and mood disorders in patients in recovery from COVID-19.

关键词： COVID-19 sleep wake disorders mood disorders Xiaoyao capsule

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Reconsidering the role of depression and common psychiatric disorders as partners in the type 2 diabetes epidemic

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World Journal of Diabetes 2024年第6期15卷 1374-1380页

作者： Angelo Emilio Claro Clelia Palanza Marianna Mazza Alessandro Rizzi Andrea Corsello Linda Tartaglione Giuseppe Marano Giovanna Elsa Ute Muti Schuenemann Marta Rigoni Alfredo Pontecorvi Luigi Janiri Paola Muti Dario Pitocco Diabetes Care Unit Department of Medical and Surgical SciencesFondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20122Italy Istituto Italiano di Antropologia ISItARome 00100Italy Unit of Psychiatry Department of NeurosciencesFondazione Policlinico Universitario A Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Dipartimento di Medicina e Chirurgia Traslazionale UniversitàCattolica del Sacro CuoreRome 00168Italy Health Research Methods Evidence and Impact DepartmentMcMaster UniversityOntario 1280Canada Department of Endocrine-Metabolic and Dermo-Rheumatology Fondazione Policlinico Universitario A Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy

Common psychiatric disorders(CPDs)and depression contribute significantly to the global epidemic of type 2 diabetes(T2D).We postulated a possible pathophysiological mechanism that through Bridge-Symptoms present in depression and CPDs,promotes the establishment of emotional eating,activation of the reward system,onset of overweight and obesity and,ultimately the increased risk of developing *** plausibility of the proposed pathophysiological mechanism is supported by the mechanism of action of drugs such as naltrexonebupropion currently approved for the treatment of both obesity/overweight with T2D and as separate active pharmaceutical ingredients in drug addiction,but also from initial evidence that is emerging regarding glucagon-like peptide 1 receptor agonists that appear to be effective in the treatment of drug *** hope that our hypothesis may be useful in interpreting the higher prevalence of CPDs and depression in patients with T2D compared with the general population and may help refine the integrated psychiatric-diabetic therapy approach to improve the treatment and or remission of T2D.

关键词： Depression Glucagon-like peptide-1 receptor agonists Diabetes mellitus type 2 Stress psychological sleep wake disorders Food addiction

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Shumian capsule(舒眠胶囊) improves symptoms of sleep mood disorder in convalescent patients of Corona Virus Disease 2019

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Journal of Traditional Chinese Medicine 2021年第6期41卷 974-981页

作者： LI Li AN Xuedong ZHANG Qing TAO Junxiu HE Jing CHEN Yun LI Kejian LIU Ru GUO Juan ZHANG Hao TONG Xiaolin BA Yuanming Department of Psychiatry Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061China Department of Psychiatry Hubei Province Academy of Traditional Chinese MedicineWuhan 430074China Department of Psychiatry the Affiliated Hospital of Hubei University of Chinese MedicineWuhan 430065China Department of Endocrinology Guang'anmen Hospital of China Academy of Chinese Medical SciencesBeijing 100053China

OBJECTIVE:To evaluate the clinical effectiveness of Shumian capsule(舒眠胶囊)in improving the symptoms of insomnia,anxiety,depression,and other symptoms of convalescent patients of ***:Totally 200 patients were collected and randomly divided into experiment group(n=100)and control group(n=100).The control group was treated with Shumian capsule simulator,and the experiment group was treated with Shumian *** improvement of TCM symptom score,the total effective rate and symptom disappearance rate of TCM symptoms in the two groups before and after treatment were observed,and the clinical effect was ***:One week after treatment,the scores of anxiety symptoms in the experiment group were significantly different from those in the control group(P0.05).There was no significant difference in the total effective rate and disappearance rate of TCM symptoms of insomnia,anxiety and depression between the experiment group and the control group(P>0.05).After 2 weeks of treatment,the scores of insomnia,anxiety,depression and the total effective rate of TCM symptoms in the experiment group were significantly different from those in the control group(P0.05).There were no significant differences in heart rate,respiration,systolic blood pressure and diastolic blood pressure between the experiment group and the control group(P>0.05).CONCLUSION:Shumian capsule can significantly improve the symptoms of insomnia,anxiety and depression in COVID-19’s convalescent patients with sleep and mood disorders.

关键词： COVID-19 convalescence sleep wake disorders mood disorders Shumian capsule

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