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A Through-Intact-skull(TIS)chronic window technique for cortical structure and function observation in mice

eLight 2022年第1期2卷 185-202页

作者： Dongyu Li Zhengwu Hu Hequn Zhang Qihang Yang Liang Zhu Yin Liu Tingting Yu Jingtan Zhu Jiamin Wu Jing He Peng Fei Wang Xi Jun Qian Dan Zhu Britton Chance Center for Biomedical Photonics‑MoE Key Laboratory for Biomedical Photonics Wuhan National Laboratory for Optoelectronics‑Advanced Biomedical Imaging FacilityHuazhong University of Science and TechnologyWuhan 430074HubeiChina Optics Valley Laboratory Hubei 430074China State Key Laboratory of Modern optical Instrumentations Centre for Optical and Electromagnetic ResearchCollege of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang UniversityHangzhou 310058China Interdisciplinary Institute of Neuroscience and Technology Department of AnesthesiologyThe Second Affiliated HospitalSchool of MedicineZhejiang UniversityKaixuan Road 258thHangzhou 310020China Department of Automation Tsinghua UniversityBeijing 100084China School of optical Electronic Information‑Wuhan National Laboratory for Optoelectronics‑Advanced Biomedical Imaging Facility Huazhong University of Science and TechnologyWuhan 430074HubeiChina

Modern optical imaging techniques provide powerful tools for observing cortical structure and functions at high *** skull windows have been established for different applications of cortical imaging,and each has its advantages and *** critical of the limitations,none of the current skull windows is suitable for observing the responses to some acute craniocerebral injuries on a large scale and at high ***,we developed a“Through-Intact-skull(TIS)window”that enables the observation of an immune response on a bilateral cortical scale and at single-cell resolution after traumatic brain injury without affecting the pathological environment of the *** TIS window also has the advantages of craniotomy-freeness,centimeter-field of view,synaptic resolution,large imaging depth,long-term observation capability,and suitability for awake ***,the TIS window is a promising new approach for intravital cortical microscopy in basic research in neuroscience.

关键词： skull optical clearing window Long-term neurovascular imaging Traumatic brain injury Awake animal

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