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The Frequency of skin Tumors and infections in Patients with Autoimmune Diseases

Journal of Cosmetics, Dermatological Sciences and Applications 2016年第4期6卷 140-147页

作者： Khalifa E. Sharquie Adil A. Noaimi Zina T. Burhan Department of Dermatology College of Medicine University of Baghdad Baghdad Iraq Iraqi and Arab Board for Dermatology and Venereology Baghdad Teaching Hospital Medical City Baghdad Iraq Department of Dermatology Baghdad Teaching Hospital Medical City Baghdad Iraq

Background: Autoimmune diseases are a vast array of organ-specific as well as systemic diseases, whose pathogenesis results from the activation of B and T lymphocytes reacting against antigens of the body’s own tissues (defined as self). Objective: To record skin tumors and infections in all autoimmune diseases gathered together in a one pathological state, compared with renal transplant recipients and normal control. Patients and Methods: Four hundred patients with different autoimmune diseases were examined. Fifty patients with pemphigus (15 males, 35 females) are aged from 20 - 70 (41.23 ± 3.89) years. Fifty patients with systemic lupus erythematosus (50 females) are aged from 17 - 45 (30.58 ± 10.08) years. One hundred patients with vitiligo (59 males, 41 females) are aged from 9 - 71 (42.89 ± 5.28) years. One hundred patients with alopecia areata (42 males, 58 females) are aged from 7 - 52 (38.67 ± 9.52) years. One hundred patients with psoriasis (56 males, 44 females) are aged from 7 - 71 (47.36 ± 8.62) years were evaluated. One hundred twenty kidney transplant recipients’ (101 males, 19 females) ages ranged from 14 - 70 (45.43 ± 4.63) years. All patients were examined thoroughly for any cutaneous manifestations and tumors and the findings were compared with the general population as a control group, which consisted of 500 healthy control individuals whose ages ranged from 20 - 71 (44.53 ± 11.48) years. This case series, descriptive, controlled study was performed in Baghdad Teaching Hospital from June 2014 to October 2015. Results: In renal transplant recipients, the findings were observed as follow herpetic infection in 30(25%), bacterial 12(10%) while fungal 24(20%) patients. These infections appeared early in the course of immunosuppression. While the tumors were noticed, the benign tumors were the commonest manifestations, which included viral warts in 45(37.5%) followed by actinic keratosis 15(12.5%), seborrheic keratosis 14(11.6%), sebaceous hyperplasia

关键词： Autoimmune Diseases Kidney Transplant skin infections skin Tumors

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Evaluation of Inhibitory Effect of the Plant Phyllanthus amarus Against Dermatophytic Fungi Microsporum gypseum

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Biomedical and Environmental Sciences 2004年第3期17卷 359-365页

作者： ANURAG AGRAWAL SHALINI SRIVASTAVA J.N.SRIVASTAVA M.M.SRIVASAVA Department of Chemistry Faculty of Science Dayalbagh Educational Institute Deemed University Agra-282 005 IndiaDepartment of Chemistry Faculty of Science Dayalbagh Educational Institute Deemed University Agra-282 005 IndiaDepartment of Botany Faculty of Science Dayalbagh Educational Institute Deemed University Agra-282 005 IndiaDepartment of Chemistry Faculty of Science Dayalbagh Educational Institute Deemed University Agra-282 005 India

Objective The antifungal activity of various solvent extracts (such as ether, chloroform, ethyl acetate and ethyl alcohol) of the plant Phyllanthus amarus against dermatophytic fungi Microsporum gypseum was observed. Method Antifungal bioassay in terms of reduction in weight, colony diameter and sporulation of the target fungal colony was carried out using Broth Dilution method. Results Root part of the plant, extracted in various organic solvents did not show any noticeable antifungal activity. The percentage inhibition observed in different solvent extracts of aerial part was found as reduction in weight: chloroform [50.3%], ethyl acetate [27.7%] and ethyl alcohol [12.1%], reduction in colony diameter: chloroform [53.4%], ethyl acetate [31.4%] and ethyl alcohol [15.0%] and reduction in sporulation: maximum inhibition in chloroform extract, at test concentration of 4000 ppm at incubation period of 8 days. Conclusion Chloroform fraction of the aerial part of the plant P. amarus shows significant inhibitory effect against dermatophytic fungi M. gypseum and requires chemical characterization for its bioactive principle.

关键词： Phyllanthus amarus Antifungal activity Microsporum gypseum skin infections

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