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Exploration of the Evaluation Method for the Soothing Effect of UV Induced Human skin damage Model

China Detergent & Cosmetics 2024年第2期9卷 61-68页

作者： Chen Silin Lin Xichun Lei Cuiting Zheng Muchuang Liao Jialin Guangdong North Indust Trial and Commercial Institutes of Green skincare Co. Ltd.China Guangdong yalijie Fine Chemical Co. Ltd.China

To explore the method of evaluating the soothing effect of human skin damage,a human skin damage model was established using UV light *** test areas were set up,namely blank control area,UV damage prevention and soothing area,immediate soothing area after UV damage and soothing area after UV *** skin parameters,including skin melanin,red pigment value,skin pigmentation value,a*value,and skin redness value,were used to characterize skin pigmentation before and after using the sample Changes in properties such as skin erythema and skin *** results showed that the method showed significant changes in the skin condition of volunteers before and after using the sample,and could achieve a soothing effect,which has certain reference significance.

关键词： UV light skin damage soothing efficacy evaluation

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Radiation dermatitis wet healing:a concept analysis

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Frontiers of Nursing 2023年第3期10卷 301-305页

作者： Juan Xu Guang Yang Ronnell D Dela Rosa Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical SciencesJinanShandong 250117China School of Nursing Philippine Women’s UniversityMetro Manila 1004Philippines College of Nursing and Midwifery Bataan Peninsula State UniversityBalangaBataan 2100Philippines

Objective:To explore the concept of radiation dermatitis wet healing through a literature review and provide references for future treatment of patients with radiation skin ***:Related ar ticles selected from China National Knowledge Infrastructure(CNKI),Wanfang Database,Pub Med,Web of Science,Medline,and EBSCO were analyzed with Rodger’s concept ***:We identified the application status of wet healing in domestic and foreign literature,defined explicit attributes of the procedure,and clarified concepts related to wet healing of radiation skin injury to provide a reference for the management of radiation dermatitis with wet ***:Treatment of radiation dermatitis with wet healing is a unique *** this concept can contribute to its development in the future and can offer a theoretical basis for treatment of patients with radiation skin injury.

关键词： concept analysis radiation skin injury radiodermatitis skin damage wet healing

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PM2.5 Exposure Elicits Oxidative Stress Responses and Mitochondrial Apoptosis Pathway Activation in HaCaT Keratinocytes

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Chinese Medical Journal 2017年第18期130卷 2205-2214页

作者： Rong Hu Xiao-Yuan Xie Si-Ka Xu Ya-Ning Wang Ming Jiang Li-Rong Wen Wei Lai Lei Guan skin Research Center Landproof Testing Technology Co. Ltd. Guangzhou Guangdong 510635 China Department of Dermatology and Venerology The Third Affiliated Hospital of Sun Yat-Sen University Guangzhou Guangdong 510630 China Department of Atmospheric Environmental Monitoring Guangdong Environmental Monitoring Center Guangzhou Guangdong 510308 China

Background：PM2.5 （aerodynamic diameter ≤ 2.5 μtm） is a dominant and ubiquitous air pollutant that has become a global concern as PM2.5 exposure has been linked to many adverse health effects including cardiovascular and pulmonary *** evidence supports a correlation between increased air PM2.5 levels and skin disorders although reports on the underlying pathophysiological mechanisms are *** stress is the most common mechanism of PM2.5-induced adverse health *** study aimed to investigate PM2.5-induced oxidative damage and apoptosis in immortalized human keratinocyte （HaCaT） ***：HaCaT cells were exposed to 0,25,50,100,or 200 μtg/ml PM2.5 for 24 *** oxygen species （ROS） generation,lipid peroxidation products,antioxidant activity,DNA damage,apoptotic protein expression,and cell apoptosis were ***：PM2.5 exposure （0-200 μtg/ml） for 24 h resulted in increased ROS levels （arbitrary unit：201.00 ± 19.28,264.50 ± 17.91,305.05 ± 19.57,427.95 ＋ 18.32,and 436.70 ± 17.77） and malondialdehyde production （0.54 ± 0.05 nmol/mg prot,0.61 ± 0.06 nmol/mg prot,0.68 ± 0.05 nmol/mg prot,0.70 ± 0.05 nmol/mg prot,and 0.76 ± 0.05 nmol/mg prot）,diminished superoxide dismutase activity （6.47 ± 0.28 NU/mg prot,5.97 ± 0.30 NU/mg prot,5.15 ± 0.42 NU/mg prot,4.08 ± 0.20 NU/mg prot,and 3.76 ± 0.37 NU/mg prot）,and increased DNA damage and apoptosis in a dose-dependent manner in HaCaT ***,cytochrome-c,caspase-3,and caspase-9 expression also increased proportionately with PM2.5 ***：PM2.5 might elicit oxidative stress and mitochondria-dependent apoptosis that likely manifests as skin irritation and damage.

关键词： Apoptosis HaCaT Ceils Oxidative Stress PM2.5 skin damage

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Photoprotection-UV Filters： Properties, Use and Safety in Sun Products

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Journal of Pharmacy and Pharmacology 2018年第9期6卷 817-824页

作者： Antonina Agolzer Studio Agolzer Studio Medico di Dermatologia via Gorghi 5 Udine 33100 Italy

Sunscreen application is a common strategy used to prevent the damage induced by UV radiations. In the last 30 years a variety of protective agents against UV exposure have been developed： physical filters, chemical filters and organic filters. Physical filters are the safest： they scatter and reflect UV rays, but are difficult to apply on the skin. Chemical filters are capable of absorbing these rays, they are cosmetically pleasant, but recent studies suggest a toxicological nature for some of these agents. Organic filters are the newest advance in sun products. Since 2003 the COLIPA Index [Europe] has regulated sun product availability on the market. In the USA, the FDA establishes the classification and the safety of sun products, which are considered topical medical drugs. This article summarizes the dermatologist＇s point of view, according to the patient＇s request, professional ethics and increasing offer of sun product.

关键词： Photoprotection UV filters skin cancer skin damage physical filters chemical filters organic filters

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