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Deletion of phosphatidylserine flippase β-subunit Tmem30a in satellite cells leads to delayed skeletal muscle regeneration

引用

Zoological Research 2021年第5期42卷 650-659页

作者： Kuan-Xiang Sun Xiao-Yan Jiang Xiao Li Yu-Jing Su Ju-Lin Wang Lin Zhang Ye-Ming Yang Xian-Jun Zhu Health Management Center Sichuan Provincial People's HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Sichuan Provincial Key Laboratory for Human Disease Gene Study Center for Medical GeneticsSichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences(2019RU026) Sichuan Academy of Medical Sciences and Sichuan Provincial People's HospitalChengduSichuan 610072 China Department of Ophthalmology First People's Hospital of ShangqiuShangqiuHenan 476000China Key Laboratory of Tibetan Medicine Research Chinese Academy of Sciences and Qinghai Provincial Key Laboratory of Tibetan Medicine ResearchNorthwest Institute of Plateau BiologyXiningQinghai 810008China

Phosphatidylserine(PS)is distributed asymmetrically in the plasma membrane of eukaryotic *** flippase(P4-ATPase)transports PS from the outer leaflet of the lipid bilayer to the inner leaflet of the membrane to maintain PS ***βsubunitTMEM30 Ais indispensable for transport and proper function of *** studies have shown that the ATP11 A and TMEM30 A complex is the molecular switch for myotube ***,the role of Tmem30 a in skeletal muscle regeneration remains *** the current study,Tmem30 a was highly expressed in the tibialis anterior(TA)muscles of dystrophin-null(mdx)mice and BaCl2-induced muscle injury model *** generated a satellite cell(SC)-specific Tmem30 a conditional knockout(cKO)mouse model to investigate the role of Tmem30 a in skeletal muscle *** regenerative ability of cKO mice was evaluated by analyzing the number and diameter of regenerated SCs after the TA muscles were injured by *** to the control mice,the cKO mice showed decreased Pax7+and MYH3+SCs,indicating diminished SC proliferation,and decreased expression of muscular regulatory factors(MYOD and MYOG),suggesting impaired myoblast proliferation in skeletal muscle *** together,these results demonstrate the essential role of Tmem30 a in skeletal muscle regeneration.

关键词： Tmem30a skeletalmuscle regeneration Knockout mouse model Atp11a Satellite cell

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