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A Case Report of Mesenteric Panniculitis and Primary sjogren’s syndrome

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Open Journal of Rheumatology and Autoimmune Diseases 2013年第4期3卷 227-230页

作者： R.L.Batten W.F.Ng Musculoskeletal Research Group Institute of Cellular MedicineNewcastle UniversityNewcastle upon TyneTyne and WearNew-castleUK.

Mesenteric Panniculitis is a benign fibro-inflammatory process involving adipose tissue of the mesentery. It is characterised by fat necrosis, chronic inflammation and fibrosis, causing thickening and shortening of the mesentery. Patients may present with localised abdominal pain, abdominal mass, intestinal obstruction and ischaemic colitis. We report a case of mesenteric panniculitis causing abdominal pain in a patient with active Primary sjogren’s syndrome. The rarity of this case makes it of interest. We review the current literature on mesenteric panniculitis and its association with connective tissue disease and inflammatory conditions. A 64-year-old Caucasian male presented in 1994 with dry mouth. A diagnosis of Primary sjogren’s syndrome (Pss) was made on salivary gland biopsy. In 2010 he presented with an exacerbation of his eye symptoms, muscle pain and fatigue. He complained of abdominal pain and night sweating, but denied any weight loss or change in bowel habit. There was no significant past medical history other than Pss. On examination he had a small right submandibular node and mild synovitis at the right proximal interphalangeal joint and carpometacarpal joint. Examination of the abdomen showed marked umbilical tenderness but no organomegally. Blood tests at this time showed an active inflammation: CRP of 61 (NR 5 mg/L), EsR 39 (NR 20 mm/s), strongly positive ENA Ro and La. IgG was elevated at 18.6 (NR 5.8-15.4), Complement was low at 0.17 (NR 0.18-0.6). An abdominal ultrasound scan demonstrated a 6 × 3 ×3 cmarea of diffuse homogenous fat encasing some mesenteric vessels in the area of focal tenderness. CT abdomen and pelvis showed oedematous mesenteric fat and lymph nodes in the jejunal small bowel mesentery, consistent with mesenteric panniculitis. Laparoscopic biopsy was discussed with the surgical team, but was felt not indicated as risk outweighed potential benefit. The patient was treated with a 9-week reducing course of oral steroids. His abdo

关键词： sjogren’s syndrome Autoimmune Disease Mesenteric Panniculitis

A case of recurrent rhabdomyolysis associated with childhood sjogren’s syndrome

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Open Journal of Pediatrics 2013年第3期3卷 276-278页

作者： shuntaro Morikawa Ichiro Kobayashi Yutaka Uzuki Masahiro Ueki Tetsuo Hattori Hayato Aoyagi Department of Pediatrics Obihiro Kyokai HospitalObihiroJapan Department of Pediatrics Hokkaido University Graduate School of MedicineSapporoJapan Department of Pediatrics Sapporo City General HospitalSapporoJapan

We report a 9-year-old Japanese girl who presented with muscle weakness and elevated serum levels of muscle-derived enzymes following mycoplasma infection. Rhabdomyolysis or myositis was suggested by magnetic resonance imaging and repeated four times within 4 years. Each episode developed following respiratory infection and spontaneously recovered. The diagnosis of sjogren’s syndrome was made by decreased salivary secretion, MR sialography, lip biopsy, and positive anti-ssA/Ro antibody. Given the rarity of rhabdomyolysis/myositis, recurrent episode could be induced by infectious disease on the basis of underlying sjogren’s syndrome. Conclusion: sjogren’s syndrome should be considered as an underlying disease of recurrent infection-induced rhabdomyolysis/ myositis.

关键词： Childhood Infection Myositis Mycoplasma Pneumoniae sjogren’s syndrome

Tubulointerstitial Nephritis Complicated with Primary sjogren’s syndrome under Treatment for Type 2 Diabetes Mellitus

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Open Journal of Nephrology 2012年第4期2卷 105-108页

作者： shinichi Antoku Hiroyuki Ito Mizuo Mifune Hiroko Nawata Masahiro Kato Department of Diabetes Metabolism and Kidney DiseaseEdogawa HospitalTokyoJapan Department of Internal Medicine Edogawa HospitalTokyoJapan Department of Neurology Edogawa HospitalTokyoJapan

Tubulointerstitial nephritis complicated by primary sj?gren’s syndrome in a patient under treatment for type 2 diabetes mellitus was diagnosed in the early stage of the disease by renal biopsy. The symptoms of primary sj?gren’s syndrome, such as thirst and polydipsia, were masked by the characteristic symptoms of type 2 diabetes mellitus. An association between sicca symptoms and diabetes mellitus (types 1 and 2) has been previously reported. Hence, it is possible that there are common underlying immunological mechanisms between primary sj?gren’s syndrome and diabetes mellitus of both types. Intervention with steroids in a timely manner appears to have prevented or slowed the progression of re- nal impairment.

关键词： Tubulointerstitial Nephritis sjogren’s syndrome Type 2 Diabetes Mellitus

Persistent Xerophthalmia in a Patient with Rheumatological Disease and Priiviary sjogren’s syndrome: Case Report from Northern Brazil

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Open Journal of Ophthalmology 2023年第2期13卷 263-266页

作者： Camile smith de Oliveira Brito Horlando Junior santos Lages Alcantara Joao de Joao Oliveira Leitao Limeira Julie souza da silvat sebastiao Barreto Falcao Neto Joao Vlctor Oliveira de Melot Youssef sabba Tayah David Tayah Milton Ruiz Alves Federal University of Amazonas Manaus Brazil

This case study aims to contribute to the literature in order to highlight the importance of this collaboration between medical specialties. A female patient R.N.N. F, age 66, from the city of Manaus, with a previous diagnosis of sjogren’s syndrome in regular follow-up by the Rheumatology team at the Araujo Lima outpatient clinic and referred to the Ophthalmology sector for complementary evaluation related to visual discomfort. The fundoscopy performed in the patient was within normal limits, but the symptoms experienced by her proved to be an important clinical finding, which has ratified the need for regular and multidisciplinary follow-up. This report unequivocally demonstrates that even in the face of tests considered within the expected limits for a given population, the clinical presentation can be specific and particular for each analyzed individual. Early screening exams should contemplate the patient in a holistic and individualized way whenever possible.

关键词： sjogren’s syndrome Ophthalmology Rheumatology screening Disease

Hypokalemic Paresis Revealing a Primary sjogren’s syndrome

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Open Journal of Internal Medicine 2015年第3期5卷 33-36页

作者： Madiha Mahfoudhi Hedia Bellali Imen Gorsane Mounira El Euch sami Turki Taieb Ben Abdallah Internal Medicine Department Charles Nicolle HospitalTunisTunisia Epidemiology and statistics Department Mami HospitalArianaTunisia

Hypokalemic acidosis can complicate a primary sjögren’s syndrome. The clinical feature is rarely revealed by manifestations due to hypokalemia. We report the case of a 46-year-old woman, admitted to explore a paresthesia and paresis of inferior limbs. The diagnosis of sjögren’s syndrome was retained since there was the association of xerophthalmia, sialadenitis at the labial biopsy and positive immunological results (anti-ssA and anti-ssB). The absence of another auto-immune or systemic illness allowed us to consider that the sjögren’s syndrome was primary. The biological explorations revealed a hyperchloremic and hypokalemic acidosis. The treatment was based on corticosteroid and potassium supplementation. The follow-up was marked by a clinical and biological amelioration.

关键词： sjogren’s syndrome Hypokalemia Interstitial Nephritis Tubulopathy

Kikuchi-Fujimoto Disease in Patients with sjogren’s syndrome

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Open Journal of Pathology 2013年第1期3卷 32-36页

作者： Lida Radfar Mehdi Radfar Kathy L.Moser Robert Hal scofield College of Dentistry University of Oklahoma Health Sciences CenterOklahoma CityUSA Arthritis&Clinical Immunology Program Oklahoma Medical Research FoundationOklahoma CityUSA

sjogren’s syndrome is a chronic autoimmune exocrinopathy associated with dry eyes and dry mouth as major clinical manifestations. It is characterized by lymphocytic infiltration of lacrimal and salivary glands and autoantibody production, especially anti-Ro (or ssA) and anti-La (or ssB). Lymphoproliferative disorders are a feature of sjogren’s syndrome, and can be considered an extraglandular manifestation of the disease. Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis is a rare form of lymphadenitis. It is reported more often in young adult women with localized lymphadenopathy (usually cervical), fever, rashes, and leukopenia. It is a self-limiting disease with resolution within 1 - 4 months in almost all patients. sjogren’s syndrome has been reported in patients with other systemic diseases including sLE and lymphomas. Here we present a patient with Kikuchi-Fujimoto disease who developed sjogren’s syndrome 8 years after her diagnosis of Kikuchi-Fujimoto disease.

关键词： sjogren’s syndrome Kikuchi-Fujimoto Disease

Visual resolution under photopic and mesopic conditions in patients with sjogren's syndrome

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国际眼科杂志:英文版 2023年第10期16卷 1662-1669页

作者： Mosaad Alhassan Amal Aldarwesh Issa Alessa Rafif Alhijji Reema Alduhayan Ali Almustanyir Department of Optometry College of Applied Medical SciencesKing Saud UniversityRiyadh 11433Saudi Arabia Imaging Research Department King Abdullah International Medical Research CenterKing Saud bin Abdelaziz University for Health SciencesRiyadh 11481Saudi Arabia

AIM:To focus on different visual resolution tasks under photopic and mesopic conditions in sjogren’s syndrome patients compared to age-matched healthy ***:The visual resolution measurements included high and low visual acuities and contrast sensitivity *** tests were conducted under photopic and then mesopic ***-one sjögren’s syndrome patients and 21 aged-matched healthy volunteers completed all the measurements in this ***:sjogren’s syndrome patients have greater impairment in contrast sensitivity than standardized visual *** reduction was significant under the mesopic ***,sjogren’s syndrome patients treated with pilocarpine suffer more than patients without pilocarpine treatment under low light ***:sjogren’s syndrome patients shows greater impairment in different visual resolution tasks due to dry eye symptoms.

关键词： sjogren’s syndrome dry eye visual acuity contrast sensitivity mesopic night vision

Relationship of immunological profiles with fibrosis in salivary gland of sjogren's syndrome

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Relationship of immunological profiles with fibrosis in sali...

Effect of Bushen Qingre Yuyin Decoction on salivary secretion, spleen Index, submandibular Gland Index, submandibular Gland Histomorphology, and aqp5 Expression in the Nonobese Diabetic Mouse Model

第十四届全国免疫学学术大会

作者： Rongjuan Chen bin wang guihua fan yan he yuan liu guixiu shi Department of Rheumatology and Clinical Immunology The First Affiliated Hospital of Xiamen University

Objective:The relationship of immunological profiles with fibrosis in salivary gland of primary sjogren’s syndrome(pss)is still *** study aimed to determine the fibrosis situation in minor salivary gland(MsG) biopsies of pss patients and its association with immunological characteristics in ***:Patients with diagnosis of pss admitted to our hospital were *** analyses of MsG sections were performed with hematoxylin & eosin(HE) and Masson’s trichrome *** lymphocytes subsets were analyzed by immunohistochemistry,in which CD3,CD4,CD8,CD19,CD163,IL-17 A and MPO were *** correlations of glandular fibrosis with blood parameters such as serum autoantibodies and complements were also ***:Fibrosis in MsG of pss patients had a significant correlation with antinuclear antibody(ANA) titer(r=0.458,P=0.007).A close positive association was found between MsG fibrosis and Chisholm & mason grading(r=0.87,Pstochemistry of biopsies revealed that CD3T cells,CD4T cells,CD8T cells,CD19B cells,CD163macrophage,IL17 AT cells and MPO monocytes were closely related to tissue fibrosis in pss salivary glands(Psis further confirmed the positive correlation of glandular fibrosis with B ***:Being the result of glandular injuries in pss,MsG fibrosis is closely related to infiltrating cells especially T cells and B ***,potentially being a treatment targets for delaying glandular dysfunction from irreversible fibrosis,the underlying correlation and aetiopathogenic roles of infiltrating cells need to be elucidated.

关键词： sjogren’s syndrome Fibrosis salivary gland Infiltrating cells

来源： cnki会议评论

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World Journal of Traditional Chinese Medicine 2020年第4期6卷 508-514页

作者： Wan-Ru Wang Huan-Yu Liu Zhi-Xiong Ren Lu Chen sai Liu Lian-Cun shi Xiao-Ping Yan Feng Mi Department of Traditional Chinese Medicine Aviation General HospitalBeijing 100011China Department of Hematology and Oncology Dongzhimen Hospital of BeijingBeijing 100700China Department of Traditional Chinese Medicine Rheumatology China‑Japan Friendship HospitalBeijing 100029China Acupoint Acupuncture Clinic Tom Kristensens Vej 425 TV2300 S CopenhagenDenmark

Objective:The objective of this study was to observe the effect of Bushen Qingre Yuyin Decoction on the spleen index,submandibular gland index,salivary secretion,submandibular gland morphology,and aquaporin 5(AQP5)expression levels in the submandibular *** and Methods:Fifty 8-week-old nonobese diabetic(NOD)female mice were randomly divided into the following five groups:model;hydroxychloroquine;and high-,medium-,and low-dose Bushen Qingre Yuyin Decoction *** blank group consisted of ten 8-week-old Balb/C *** Yuyin Qingre Decoction was administered by gavage at 20,40,and 80 g/kg in the low-,medium-,and high-dose groups,*** hydroxychloroquine group was administered hydroxychloroquine at a dose of 80 mg/kg by *** normal and model groups were administered the same amount of *** the different administrations,the amount of salivary secretion in the mice was regularly *** 12 weeks,the mice were sacrificed,and their submandibular gland tissues were excised,stained with hematoxylin-eosin,and pathologically ***5 expression levels in the tissues were detected using real-time polymerase chain ***:The spleen index of mice in the high-dose group was higher than that in the model group(Psubmandibular gland index of the hydroxychloroquine group and all the Bushen Qingre Yuyin Decoction prescription groups was higher than that in the model group(Ps,the salivary volume of the hydroxychloroquine group and all the Bushen Qingre Yuyin Decoction prescription groups was significantly higher than that of the model group(Pstration group was significantly reduced(Pssion levels in the submandibular glands of mice had significantly increased in the hydroxychloroquine and high-dose groups(Pse group showing the best ***:Bushen Qingre Yuyin D

关键词： Aquaporin 5 Bushen Qingre Yuyin Decoction nonobese diabetic mouse sjogren’s syndrome submandibular gland histomorphology