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Proton beam therapy of periorbital sinonasal squamous cell carcinoma: Two case reports and review of literature

World Journal of Clinical Oncology 2020年第8期11卷 655-672页

作者： Yi-Lan Lin Department of Radiation Oncology Rinecker Proton Therapy CenterMunich 81371Germany

BACKGROUND sinonasal malignancies are rare but demanding due to complex anatomy,usually late diagnosis,and inconsistent therapy strategy based on multimodality *** cell carcinoma(SCC)is the most common histology,with poorer *** the setting of orbital invasion,an orbital exenteration may be ***,in case of primary rejection of disfiguring surgery or unresectable disease,proton beam therapy(PBT)should be largely considered,allowing for better sparing of neighboring critical structures and improved outcomes by dose *** SUMMARY A 62-year-old male presented with a recurrent SCC in the nasal septum abutting frontal skull base and bilateral orbits at 7 mo after primary partial nasal *** of refusal of face-deforming surgery and considerable adverse effects of conventional radiotherapy,the patient underwent a PBT by hyperfractionated accelerated scheme,resulting in complete response and moderate *** 2 years,a nasal reconstruction was implemented with satisfactory appearance and recurrence-freedom to *** patient with an initially extended sinonasal SCC,invading right orbit and facial soft tissue,declined an orbital exenteration and was treated with a normofractionated PBT to the gross tumor and elective cervical *** follow-up showed a continuous tumor remission with reasonable late toxicities,such as cataract and telangiectasia on the *** T4a stage and disapproval of concurrent chemotherapy owing to individual choice,both patients still achieved outstanding treatment outcomes with PBT *** PBT enabled orbit preservation and excellent tumor control without severe adverse effects on both presented patients with locally advanced sinonasal SCC.

关键词： Proton beam therapy Intensity modulated proton therapy sinonasal malignancies Squamous cell carcinoma Orbital exenteration Case report

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