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Induction chemotherapy with docetaxel,cisplatin and fluorouracil followed by concurrent chemoradiotherapy for unresectable sinonasal undifferentiated carcinoma: Two cases of report

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World Journal of Clinical Cases 2019年第6期7卷 765-772页

作者： Sho Watanabe Yoshitaka Honma Naoya Murakami Hiroshi Igaki Taisuke Mori Hidekazu Hirano Natsuko Okita Hirokazu Shoji Satoru Iwasa Atsuo Takashima Ken Kato Kenya Kobayashi Fumihiko Matsumoto Seiichi Yoshimoto Jun Itami Narikazu Boku Department of Head and Neck Medical Oncology National Cancer Center Hospital Department of Radiation Oncology National Cancer Center Hospital Department of Pathology and Clinical Laboratories National Cancer Center Hospital Department of Gastrointestinal Medical Oncology National Cancer Center Hospital Department of Head and Neck Surgery National Cancer Center Hospital

BACKGROUND sinonasal undifferentiated carcinoma(SNUC) is a rare aggressive tumor that is often unresectable. Optimal treatment for patients with unresectable,locally advanced SNUC(LA-SNUC) has not been established,and the patient outcome remains poor. We report two cases of unresectable LA-SNUC in which induction chemotherapy with docetaxel,cisplatin and fluorouracil(TPF) followed by radiotherapy with concurrent cisplatin(CCRT),a standard treatment option for locally advanced head and neck cancer,demonstrated promising *** SUMMARY A 39-year-old man presented with tearing and pain in the right eye. A biopsy of the tumor invading the sinonasal cavities,right orbit and cranial base confirmed the diagnosis of LA-SNUC. Induction TPF chemotherapy induced remarkable tumor shrinkage and rapidly improved the symptoms. He subsequently received CCRT and achieved complete remission of the disease. The other case is a 21-year-old man who presented with worsening vision. The unresectable tumor involving the nasal septum and cranial base was pathologically diagnosed as SNUC. TPF chemotherapy followed by CCRT yielded complete remission of the disease with preserved visual function. Both patients have been disease-free for44 *** Induction TPF chemotherapy followed by CCRT may remarkably improve the outcomes in LA-SNUC patients.

关键词： sinonasal undifferentiated carcinoma Chemotherapy with docetaxel, cisplatin and fluorouracil chemotherapy Docetaxel Cisplatin Fluorouracil Intensity-modulated radiotherapy Chemoradiotherapy Case report

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Multidisciplinary approach to children with sinonasal tumors: A review

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Pediatric Investigation 2019年第3期3卷 173-179页

作者： Norhafiza Mat Lazim Baharudin Abdullah Department of Otorhinolaryngology-Head and Neck Surgery School of Medical SciencesHealth CampusKubang KerianKelantanMalaysia

sinonasal tumors in children are rare and difficult to manage. These tumors can be broadly categorized into congenital or acquired and benign or malignant. The tumors mainly arise from the mucosa, cartilage, or bone of the nasal cavity and may occupy areas of the nasal septum, turbinates, osteomeatal complex, sinuses, and nasopharynx. The management of pediatric sinonasal tumors is challenging, especially in cases of malignancy. Malignant tumors pose a treatment dilemma because most such tumors tend to be aggressive and carry a poor prognosis. Multiple complications associated with the primary disease or treatment may occur, and such complications need to be fully addressed to provide optimal care. In most cases, a multidisciplinary team approach will offer the best possible outcome for children with sinonasal tumors.

关键词： Benign tumor Chemoradiation Endonasal endoscopic surgery Malignant tumor sinonasal tumor Surgery

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sinonasal Undifferentiated Carcinoma—A Case Report

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International Journal of Otolaryngology and Head & Neck Surgery 2014年第6期3卷 382-386页

作者： C. Aparna I. V. Renuka Department of Pathology Guntur Medical College Guntur India

sinonasal tumors with neuroendocrine differentiation are uncommon. They arise from schneiderian epithelium. The authors reported a case in a fifty-six years old female patient who came with complaints of headache and epistaxis. Differential diagnosis and review of literature are presented in detail. This case is presented in view of its rarity.

关键词： sinonasal Undifferentiated Carcinoma sinonasal Neuro Endocrine Carcinoma Schneiderian Epithelium

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sinonasal Schwannoma: A Case Report and Updated Review of the Literature

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Open Journal of Medical Imaging 2015年第2期5卷 66-70页

作者： Edwin A. Takahashi Nathan C. Hull Christopher J. Stevens Joseph M. Hoxworth Steven M. Weindling Christopher P. Wood Department of Radiology Mayo Clinic Rochester USA Department of Radiology Mayo Clinic Scottsdale USA Department of Radiology Mayo Clinic Jacksonville USA

sinonasal schwannomas are rare, benign and slow-growing peripheral nerve sheath tumors without age, race, or gender predilection. We present the unusual case of a 59-year-old female who pre-sented with right-sided retro-orbital pressure and rhinorrhea. Radiographic imaging revealed a mass centered in the right superior nasal cavity with extension through the cribriform plate into the right more than the left subfrontal region. Biopsy confirmed the diagnosis of a sinonasal schwannoma, which was resected via nasal endoscopic surgery and ethmoidectomy. These tumors, albeit rare, should be considered in the differential diagnosis for patients presenting with a para-nasal sinus mass to ensure inclusion of this benign lesion and avoid unnecessary aggressive in-tervention.

关键词： Neurilemmoma Paranasal Sinus sinonasal Tract Schwannoma

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Undifferentiated sinonasal Carcinoma- Case Report

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Journal of Pharmacy and Pharmacology 2017年第7期5卷 434-438页

作者： Miroljub Todorovic Tanja Boljevic Department of Ear Hospital Danilo L Vuka Micunovica 1 Cetinje 81250 Montenegro Clinic for Otorhinolaryngology and Maxillofacial Surgery Clinical Center of Montenegro Podgorica 81000 Montenegro

SNUC （undifferentiated sinonasal carcinoma） is a rare tumor. The exact cause of this cancer is not known. Patients usually have signs and symptoms of bleeding from the nose, runny nose, duplicate photos, symptoms of chronic sinus infections and nose, nasal obstruction, or facial pain. We reported a case of seventy year old patient with sinonasal undifferentiated carcinoma in the right maxillary sinus. Six months ago, the patient was conducted operations polyp in the right nasal hall. He had pain in the right side of his face and swelling in the mouth in the area of the upper jaw on the right side. The patient was operated tumor of the right maxillary sinus, with expansion in the ethmoid sinus, nasal cavity and infratemporal space. The neck dissection was done on the same side. Postoperatively, he received radiation therapy and chemotherapy. SNUC is very rare aggressive cancer that requires aggressive therapy. This cancer is considered in need of modified maxillary sinuses, as well as for modified sinus in polyps or after the operation of the same. Despite extensive surgery, radio therapy and implemented chemotherapy, the prognosis of these tumors is very poor

关键词： sinonasal undifferentiated carcinoma.

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Recurrent sinonasal Hemangiopericytoma: A Rare Case Report

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International Journal of Otolaryngology and Head & Neck Surgery 2020年第1期9卷 14-18页

作者： Worood Husain Mahran Kazerooni Ahmed Jamal Department of ENT Head and Neck Surgery Salmaniya Medical Complex Manama Kingdom of Bahrain

Hemangiopericytoma (HPC) is a rare vascular tumor arising from capillary pericytes. This tumor represents 3% - 5% of all soft tissue sarcomas and 1% of all vascular tumors. Only 15% - 30% of cases occur in the head and neck region, among which sinonasal hemangiopericytoma (HPC) is accounted for around 5% of cases. Hemangiopericytoma (HPC) has a tendency for recurrence. Here, a case of recurrent nasal hemangiopericytoma (HPC) after 12 years of treatment is reported.

关键词： Hemangiopericytoma sinonasal Hemangiopericytoma Endoscopic Approach Staghorn Pattern

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Survival in unresectable sinonasal undifferentiated carcinoma treated with concurrent intra-arterial cisplatin and radiation

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World Journal of Clinical Cases 2015年第2期3卷 191-195页

作者： Sonal S Noticewala Loren K Mell Scott E Olson William Read Department of Radiation Medicine and Applied Sciences Center for Advanced Radiotherapy TechnologiesUniversity of California San Diego Division of Neurosurgery University of California San Diego Department of Hematology and Medical Oncology Emory University

We report the successful use of RADPLAT to treat a patient with an unresectable T4N0 sinonasal undifferentiated carcinoma. This patient received 4 cycles of weekly intra-arterial cisplatin together with thiosulfate infusion with concurrent radiation therapy. Radiation therapy was given in 28 daily fractions to 54 Gy using intensity-modulated radiation therapy followed by a hypofractionated stereotactic boost of 3 fractions to 13 Gy to a total dose of 67 Gy in 31 fractions to the nasal sinus and bilateral neck. Intra-arterial cisplatin was administered using a bilateral approach due to the midline site of this tumor. Within days of the first intra-arterial cisplatin, there was an obvious decrease in tumor size. She has been followed with magnetic resonance imaging and positron emission tomography, and remains disease-free 47 mo post-treatment. Centers with expertise in intra-arterial chemotherapy could consider the RADPLAT approach for patients with unresectable sinonasal undifferentiated carcinoma.

关键词： sinonasal undifferentiated carcinoma Radiation Intra-arterial cisplatin Survival RADPLAT

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Carcinosarcoma of the nasal cavity and paranasal sinuses:Review of the national cancer database

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第2期9卷 115-122页

作者： Jacob C.Harris Jacob G.Eide Rijul S.Kshirsagar Jason A.Brant James N.Palmer Nithin D.Adappa Department of Otorhinolaryngology-Head and NeckSurgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Background:Carcinosarcomas are rare,aggressive malignancies that can arise in the nasal cavity and paranasal *** are limited outcome data ***,we sought to use the National Cancer Database(NCDB)to characterize patient demographics and ***:A retrospective analysis of the NCDB from 2004 to 2016 for patients with sinonasal carcinosarcoma was ***:Thirty patients were *** patients were predominantly male(n=20),white(n=23),and privately insured(n=15),with an average age of 62.4 *** nasal cavity was the most common subsite(n=14),followed by the maxillary sinus(n=8).Most patient were treated with surgery followed by radiation(n=23),with the remaining undergoing surgery alone(n=4),radiation alone(n=2),or no treatment(n=1).One-third(n=10)received adjuvant *** 1-and 5-year overall survival(OS)in the cohort were 79.2%and 43.3%,*** log-rank testing showed OS varied based on intervention(Psinonasal carcinosarcoma *** research is needed to identify predictors of overall survival,and to assess the optimal roles for radiation and systemic chemotherapy.

关键词： cancer carcinosarcoma National Cancer Database NCDB outcomes sinonasal survival

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Esthesioneuroblastoma Masquerading as Chronic Rhinosinusitis

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Case Reports in Clinical Medicine 2015年第9期4卷 303-308页

作者： Sylvia G. McCulloch Harold Y. Lau Yves Starreveld John T. Lysack Desiree Hao Department of Internal Medicine Faculty of Medicine University of Calgary Calgary Canada Tom Baker Cancer Center/University of Calgary Calgary Canada Division of Neurosurgery Foothills Medical Centre Calgary Canada Clinical Neurosciences and Surgery University of Calgary Department of Diagnostic Imaging Foothills Medical Centre Calgary Canada

Background: Esthesioneuroblastoma, a rare tumour of the nasal vault, can present with symptoms that can be mistaken for common conditions such as chronic rhinosinusitis or recurrent epistaxis. Case presentation: A 52-year-old, previously healthy, Caucasian female presented to the emergency room with two months of nasal congestion and a spontaneous, protracted nosebleed that required a nasal clamp to settle. In the following months she had another episode of epistaxis in addition to fatigue, headaches, anosmia, difficulty breathing, worsening vision, weight loss and behavioral changes. Subsequent investigations led to the diagnosis of esthesioneuroblastoma. Conclusion: When patients present with recurrent epistaxis or chronic rhinosinusitis that does not respond to a reasonable course of medical therapy and/or have atypical associated symptoms, further investigations should be considered. The presences of red flags, such as weight loss, severe headaches, vision changes or bizarre behavior are also clues that alternate diagnoses and further additional workup should be considered.

关键词： Esthesioneuroblastoma sinonasal Neoplasms Sinusitis Epistaxis

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Endoscopic Management of Recurrent Anterior Skull Base Schwannoma

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International Journal of Otolaryngology and Head & Neck Surgery 2013年第2期2卷 52-56页

作者： Jivianne T. Lee Lester D. R. Thompson Rohit Garg David B. Keschner Terry Shibuya Department of Pathology Woodland Hills Medical Center Southern California Permanente Medical Group Woodland Hills USA Orange County Sinus and Skull Base Institute Southern California Permanente Medical Group Irvine USA

Objectives: sinonasal schwannomas account for less than 4% of head and neck schwannomas, with the primary treatment modality being surgical excision via external approaches. The aim of this report is to present a rare case of recurrent schwannoma of the ethmoid cavity involving the anterior skull base which was successfully managed with endoscopic resection. Study Design: Case report and review of the literature. Methods: The clinical presentation, radiographic features, histopathologic characteristics, surgical approach, and patient outcome were examined in the context of a literature review. Results: A 43-year-old woman presented with a 9-month history of left facial pain and pressure. She had a prior history of sinonasal schwannoma excision with cerebrospinal fluid (CSF) leak repair via bifrontal craniotomy in 2007. Magnetic resonance imaging (MRI) and nasal endoscopy revealed a left ethmoid mass measuring 2.2 cm × 2.7 cm × 2.4 cm abutting the anterior skull base. The tumor was completely removed using a transnasal endoscopic approach, and the anterior skull base reconstructed with tensor fascia lata graft. Histology of the specimen showed schwannoma, and there has been no evidence of tumor recurrence nor CSF leak after 24 months of follow-up. Conclusion: With continual advances in surgical technique and instrumentation, sinonasal schwannomas have become increasingly more amenable to endoscopic resection even in the case of recurrence and skull base involvement.

关键词： Endoscopic Recurrent Anterior Skull Base sinonasal Schwannoma

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