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sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-Jia Chen Xin-Ning Yu Hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

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Comprehensive analysis of the potential role and prognostic value of sine oculis homeobox homolog family in colorectal cancer

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2138-2156页

作者： Ze-Xuan Fang Chun-Lan Li Zheng Wu Yan-Yu Hou Hua-Tao Wu Jing Liu Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery The First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

BACKGROUND Several genes,important for development,are reduced or silenced in adulthood,and their abnormal expression has been related to the occurrence and development of malignant *** sine oculis homeobox homolog(SIX)proteins belong to the homeobox family and play important roles in the development of different ***,SIXs are predicted to have chromatin-binding and DNA-binding transcription factor activity with reported roles in ***,a comprehensive analysis of SIXs in colorectal cancers(CRCs)has not been *** To explore the expression pattern of six SIX proteins in CRCs and their relationship with the clinicopathological parameters of CRC patients as well as investigate the potential utilization of SIXs as novel prognostic indicators in *** The expression level of SIXs in normal tissues of different organs and related cancerous tissues was analyzed in the Human Protein ***-Meier Plotter and GEPIA2 were used to analyze the prognostic values of *** analyze the potential signaling pathways with SIX family involvement,LinkedOmics was used to perform Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses of SIX4-related ***,immunohistochemical experiments were performed on CRC tissues and adjacent normal tissues,and we examined the SIX4 expression level in 87 pairs of patients with tissue *** relationship between SIX4 and clinicopathological parameters in CRC patients was tested using theχ2 test and Fisher’s exact probability to verify the results of the database *** The RNA levels of SIX1-4 and SIX6 were relatively low in normal human tissues,while SIX5 was highly expressed at both the RNA and protein ***,the protein level of SIX4 was found to be elevated in various *** CRC tissues,SIX1,SIX2 and SIX4 were elevated in cancer tissues compared with adjacent normal *** all SIXs,a high level of SIX4 was found to be associated w

关键词： sine oculis homeobox homolog Colorectal cancer Development Treatment Expression Prognostic indicator

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