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Enhanced urease inhibition activity of Ag nanomaterials capped with N-substituted methyl 5-acetamido-β-resorcylate

Progress in Natural Science:Materials International 2019年第2期29卷 129-137页

作者： Syeda Sohaila Naz Muhammad Raza Shah Nazar Ul Islam Syed Sartaj Alam Nanosciences and Technology Department National Centre for Physics Quaid-i-Azam University Campus ICCBS H.E.J.Research Institute of Chemistry University of Karachi Institute of Chemical Sciences University of Peshawar Sarhad University of Science and Information Technology Department of Plant Pathology The University of AgriculturePeshawar Pakistan

Medically, bacterial ureases are important virulent factors and are used for treatment of peptic ulcers and urinary tones. Reported urease inhibitors are associated with various side effects including antibiotic resistance as a major one. Still there is an urgent need to synthesize new urease inhibitors. In this context we have synthesized new urease inhibitor i.e. AgL that is composed of Ag nanomaterials capped with N-substituted methyl 5-acetamido-β-resorcylate(L). The conjugation of L to silver was confirmed through FTIR, UV–vis and TEM *** silver nanomaterials(Ag) were also prepared. The stability of AgL nanostructures was determined against various parameters(temperature, high salt concentration, pH) and found to be stable. The in vitro antimicrobial(antibacterial, antifungal), enzyme inhibition(xanthine oxidase, urease, carbonic anhydrase, α-chymotrypsin,cholinesterase) and antioxidant activities of AgL were investigated and compared with Ag, L and standard *** comparison to other bioactivities, AgL shows statistically enhanced selective enzyme inhibition activity against urease enzyme. Urease inhibition activity of AgL was significantly greater than standard drug(thiourea),L and Ag. On a per weight basis, AgL required about 11–18 times less amount of L for inhibition of urease enzyme.

关键词： β-Resorcylic acid N-Substituted methyl 5-acetamido-β-resorcylate silver nanomaterials Enhanced urease inhibition activity

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