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装载自噬抑制剂的纳米银核介孔硅协同增强胶质瘤放疗

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Science China Materials 2023年第7期66卷 2902-2912页

作者：吴昊袁月辉康世雄周高信谷越袁星怡李嘉婕顾宁 School of Biomedical Engineering and Informatics Nanjing Medical UniversityNanjing 211166China Medical School Nanjing UniversityNanjing 210093China

先前研究表明,银纳米颗粒可作为潜在的胶质瘤放疗的增敏剂,但这一作用受到自噬的限制.作为最有前途的药物递送载体之一,介孔二氧化硅纳米球由于其优异的药物负载性能、固有的生物相容性和可调节的孔径,对生物医学的发展做出了巨大贡献.... 详细信息

先前研究表明,银纳米颗粒可作为潜在的胶质瘤放疗的增敏剂,但这一作用受到自噬的限制.作为最有前途的药物递送载体之一,介孔二氧化硅纳米球由于其优异的药物负载性能、固有的生物相容性和可调节的孔径,对生物医学的发展做出了巨大贡献.在此,我们设计了一种负载自噬抑制剂3-甲基腺嘌呤的纳米银核介孔二氧化硅纳米球,其在体外和体内均表现出优异的协同抗癌作用.并且证实了抑制自噬可以进一步改善胶质瘤放疗的效果.此外,还从与氧化应激相关的核转录因子Nrf2的角度探讨了可能的机制,包括自噬抑制增强辐射诱导的氧化应激损伤以及Nrf2与自噬的相互作用.这项研究为将纳米银作为与自噬抑制剂结合用于胶质瘤放射增敏提供了一个愿景,并为其临床转化提供了一种可行的策略.

关键词： glioma radiotherapy autophagy mesoporous silica silver nanoparticles

Impact of density of coating agent on antibacterial activity of silver nanoparticle impregnated plasma treated activated carbon

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Journal of Environmental Sciences 2018年第5期30卷 136-144页

作者： Pritam Biswas Rajdip BANDyopadhyaya Department of Chemical Engineering Indian Institute of Technology Bombay

To use stabilized nanoparticles（NPs） in water as disinfectants over a very long period, the amount of coating agent（for NP stabilization） needs to be optimized. To this end, silver nanoparticles（Ag-NPs） with two different coating densities of tri-sodium citrate（12.05 and46.17 molecules/nm2, respectively）, yet of very similar particle size（29 and 27 nm, respectively）were synthesized. Both sets of citrate capped NPs were then separately impregnated on plasma treated activated carbon（AC）, with similar Ag loading of 0.8 and 0.82 wt.%, respectively. On passing contaminated water（containing 10~4 CFU Escherichia coli/m L of water） through a continuous flow-column packed with Ag/AC, zero cell concentration was achieved in 22 and 39 min, with Ag-NPs（impregnated on AC, named as Ag/AC） having lower and higher coating density, respectively. Therefore, even on ensuring similar Ag-NP size and loading, there is a significant difference in antibacterial performance based on citrate coating density in Ag/*** is observed in lower coating density case, due to both：（i） higher Ag~＋ ion release from Ag-NP and（ii） stronger binding of individual Ag-NPs on AC. The latter ensures that, Ag-NP does not detach from the AC surface for a long duration. TGA-DSC shows that Ag-NPs with a low coating density bind to AC with 4.55 times higher adsorption energy, compared to Ag/AC with a high coating density, implying stronger binding. Therefore, coating density is an important parameter for achieving higher antibacterial efficacy, translating into a faster decontamination rate in experiments, over a long period of flow-column operation.

关键词： silver nanoparticles Activated carbon Escherichia coliCitrate coating Coating density Water disinfection

Structural and luminescence enhancement properties of Eu^(3+)/Ag nanocrystallites doped SiO_2-TiO_2 matrices

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Journal of Rare Earths 2013年第5期31卷 441-448页

作者： Arun Kumar K V Revathy K P Prathibha Vasudevan Sunil Thomas Biju P R Unnikrishnan N V School of Pure & Applied Physics Mahatma Gandhi University

We reported here the structural and optical characterisation of silver nanocrystallites/Eu3＋：SiO2-TiO2 matrices synthesised through sol-gel route. Structural characterisations were done by using energy dispersive spectroscopy （EDX）, X-ray diffraction （XRD）, Fourier transform infrared spectroscopy （FTIR）, atomic force microscope （AFM） and transmission electron microscopy （TEM） measurements and optical characterisations were performed by absorption and emission spectroscopy. The TEM and XRD measurements confirmed the presence of nanocrystals. A broad absorption band was observed due to surface plasmon resonance of silver nanocrystals. The effect of silver nanocrystals on the emission spectrum of Eu3＋ doped SiO2-TiO2 matrices was discussed. An attempt was made to explain this fluorescence enhancement by invoking phenomena such as energy transfer, asymmetry ratio, surface plasmon, surface roughness, crystallinity and grain boundary. Our analysis, based on the experimental results, suggested that all the phenomena except crystallinity and grain boundary had favourable effects on fluorescence enhancement. We also estimated the relevant parameters associated with the phenomena that affected the fluorescence emission from the Eu3＋ ions in the matrix. It was seen that the theoretical estimate of fluorescence enhancement agreed well with the experimental estimate.

关键词： sol-gel luminescence SiO2-TiO2 silver nanoparticles rare earths

Facile fabrication of highly conductive, waterproof, and washable e-textiles for wearable applications

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Nano Research 2021年第4期14卷 1043-1052页

作者： Ben Niu Su Yang Tao Hua Xiao Tian MingKin Koo Nanotechnology Center Institute of Textiles&ClothingThe Hong Kong Polytechnic UniversityHung HornHong Kong 999077China

曰ectronic textiles(e-textiles),known as a newly-developed innovation combining the textile and electronic technologies,are burgeoning as the next-generation of wearable electronics for lots of promising ***,a big concern is the durability of the e-textiles during practical ***,we describe a facile method tofabricate mechanically and electrically durable e-textiles by chemical deposition of silver nanoparticles(AgNPs)on widely used cotton *** interface between AgNPs and fabric was tightly strengthened by the bioinspired polydopamine,and a highly waterproof and anticorrosive surface was further obtained by modifying with a fluorine containing agent of 1H,1H,2H,2/~/-perfuorodecanethiol(PFDT).In addition to the low sheet resistance of 0.26 ohm/sq and high conductivity of 233.4 S/cm,the e-textiles present outstanding stability to different mechanical deformations including ultrasonication,bending and machine ***,thanks to the surface roughness of AgNPs and low surface energy of PFDT,a superhydrophobic surface,with a water contact angle of ca.152°,was further obtained,endowing the e-textiles excellent anti-corrosion to water,acid/alkaline solution and various liquids(e.g.,milk,coffee and tea).Finally,the application of this highly conductive e-textiles in wearable thermal therapy is *** with the facile,all-solution-based,and environmentally friendly fabrication protocol,the e-textiles show great potential of large-scale applications in wearable electronics.

关键词： electronic textiles silver nanoparticles washability waterproof

Embedding variable micro-capacitors polydimethylsiloxane for enhancing output of triboelectric nanogenerator in power

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Nano Research 2017年第1期10卷 320-330页

作者： Xiaona Xia Jie Chen Hengyu Guo Guanlin Liu Dapeng Wei Yi Xi Xue Wang Chenguo Hu Department of Applied Physics Chongqing University Chongqing 400044 China Chongqing Key Laboratory of Multi-scale Manufacturing Technology Chongqing Institute of Green and Intelligent Technology Chinese Academy of 5ciences Chongqing 400714 China

Polydimethylsiloxane （PDMS） is an excellent material for investigating the mechanism of triboelectricity as it can easily be used to construct various microstructures. In this study, micro-capacitors （MCs） and variable microcapacitors （VMCs） were embedded in PDMS by filling PDMS with silver nanoparticles （NPs） and constructing an internal cellular structure. The output performance of the triboelectric nanogenerators （TENGs） based on MCs@PDMS and VMCs@PDMS films was systematically investigated, with variation of the filling content of silver NPs and the pore ratio and size. The microstructure, permittivity, dielectric loss, and capacitance of the VMCs@PDMS films were well characterized. The output current of the TENG based on the VMCs@PDMS film was respectively 4.0 and 1.6 times higher than that of the TENGs based on the pure PDMS film and MCs@PDMS film, and the output power density of the former reached 6 W·m-2. This study sheds light on the physical nature of conductive nanoparticle fillings and cellular structures in dielectric triboelectric polymers.

关键词： cellular structure polydimethylsiloxane silver nanoparticles variable micro-capacitor

Schiff-base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes

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Nano Research 2021年第8期14卷 2735-2748页

作者： Ling Cai Yanqiang Huang Yuanyuan Duan Qiao Liu Qilan Xu Jia Jia Jianming Wang Qian Tong Peipei Luo Yujie Wen Luming Peng Qian Wu Xudong Hang Huijun Jiang Ping Zhu Yanmei Yang Boshen Zhou Liping Zeng Hongkai Bi Jin Chen Center for Global Health The Key Laboratory of Modern ToxicologyMinistry of EducationSchool of Public HealthNanjing Medical UniversityNanjing 211166China Department of Pathogen Biology Jiangsu Key Laboratory of Pathogen BiologyNanjing Medical UniversityNanjing 211166China Research Center for the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for Nationalities Baise 533000China The Laboratory Center for Basic Medical Sciences Nanjing Medical UniversityNanjing 211166China Key Laboratory of Mesoscopic Chemistry of MOE and Collaborative Innovation Center of Chemistry for Life Sciences School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210023China School of Pharmacy Nanjing Medical UniversityNanjing 211166China Department of Gastroenterology Sir Run Run HospitalNanjing Medical UniversityNanjing 211166China Key Laboratory of Antibody Technique of National Health Commission Nanjing Medical UniversityNanjing 211166China

Infectious microbes that spread easily in healthcare facilities remain as the severe threat for the public health,especially among immunocompromised *** the intricate problem of dramatic increase in resistance to common biocides,the development of safe and efficient biocide formulated agents to alleviate drug resistance is highly *** this study,Schiff-base ligands were successfully formed on natural biopolymer of epsilon-poly-L-lysine(ε-PL)decorated aldehyde functionalized mesoporous silica SBA-15(CHO-SBA-15)for the selective coordination of silver ions,which was affirmed by various physicochemical *** the identified broad-spectrum antibacterial activities,the as-prepared Schiff-base silver nanocomplex(CHO-SBA-15/ε-PL/Ag,CLA-1)exhibited an improved inhibitory effect on infectious pathogen growth typified by Escherichia coli and Staphylococcus aureus in comparison with two control silver complexes without Schiff-base conjugates,SBA-15/ε-PL/Ag and CHO-SBA-15/Ag,*** addition,CLA-1 remarkably inhibited the growth of Mycobacterium tuberculosis due to the excellent antimicrobial activity of silver ***,CLA-1 kills Candida albicans cells,inhibits biofilm formation,and eliminates preformed biofilms,with no development of resistance during continuous serial *** antifungal activity is connected to disruption of bacterial cell membranes and increased levels of intracellular reactive oxygen *** mouse models of multidrug-resistant *** infection,CLA-1 exhibited efficient in vivo fungicidal efficacy superior to two antifungal drugs,amphotericin B and ***,CLA-1 treatment induces negligible toxicity against normal tissues with ***,this study reveals the pivotal role of the molecular design of Schiff-base silver nanocomplex formation on biopolymer surface-functionalized silica mesopores as a green and efficient nanoplatform to tackle infectious microbes.

关键词： biopolymer drug delivery mesoporous silica silver nanoparticles antimicrobial drug resistance

Preparation and Antibacterial Activity of Three-component NiFe_2O_4@PANI@Ag Nanocomposite

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Journal of Materials Science & Technology 2014年第7期30卷 656-660页

作者： M.Kooti P.Kharazi H.Motamedi Department of Chemistry Shahid Chamran UniversityAhvaz 61357-43169Iran Department of Biology Shahid Chamran UniversityAhvaz 61357-43169Iran

A new three-component and magnetically responsive NiFe2O4@PANI@Ag nanocomposite has been fabricated by coating of nickel ferrite, NiFe2O4, nanoparticles with polyaniline （PANI） and subsequent immobilization of silver nanoparticles onto the surface of polyaniline shell. The as-prepared nanocomposite has been characterized by X-ray diffraction （XRD）, Fourier transform infrared spectroscopy （FT-IR）, scanning electron microscopy （SEM）, and vibrating sample magnetometer （VSM）. The saturation magnetization of the NiFe2O4 core decreases dramatically after coating with polyaniline and silver nanoparticles, however, the nanocomposite NiFe2O4@PANI@Ag can be still separated from solution media through magnetic decantation. The antibacterial activity of the synthesized nanocomposite was studied and compared with those of naked NiFe2O4, NiFe2O4@PANI and some standard antibacterial drugs.

关键词： Antibacterial activity Nanocomposite Core/shell Ferrite Magnetic nanoparticles silver nanoparticles

Deposition of hexagonal boron nitride thin films on silver nanoparticle substrates and surface enhanced infrared absorption

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Chinese Physics B 2014年第4期23卷 513-516页

作者：邓金祥陈亮满超孔乐崔敏高学飞 School of Applied Mathematics and Physics Beijing University of Technology

silver nanoparticle thin films with different average particle diameters are grown on silicon substrates. Boron nitride thin films are then deposited on the silver nanoparticle interlayers by radio frequency （RF） magnetron sputtering. The boron nitride thin films are characterized by Fourier transform infrared spectra. The average particle diameters of silver nanoparticle thin films are 126.6, 78.4, and 178.8 nm. The results show that the sizes of the silver nanoparticles have effects on the intensities of infrared spectra of boron nitride thin films. An enhanced infrared absorption is detected for boron nitride thin film grown on silver nanoparticle thin film. This result is helpful to study the growth mechanism of boron nitride thin film.

关键词： hexagonal boron nitride thin film silver nanoparticles surface enhanced infrared absorption

silver Nanoparticle Fabrication by Laser Ablation in Polyvinyl Alcohol Solutions

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Chinese Physics Letters 2014年第7期31卷 193-196页

作者： Halimah Mohamed. K Mahmoud Goodarz Naseri Amir Reza Sadrolhosseini Arash Dehzangi Ahmad Kamalianfar Elias B Saion Reza Zamiri Hossein Abastabar Ahangar Burhanuddin Y. Majlis Department of Physics Faculty of Science Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia Department of Physics Faculty of Science Malayer University Malayer Iran Wireless and Photonics Networks Research Center of Excellence (WiPNET) Faculty of Engineering Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia Institute of Microengineering and Nanoelectronics (IMEN) Universiti Kebangsaan Malaysia 43600 Bangi Selangor Malaysia Department of Physics 3ahrom University Jahrom Iran Department of Chemistry Faculty of Science Universiti Putra Malaysia 43400 UPM Serdang Selangor Malaysia

A laser ablation technique is applied for synthesis of silver nanoparticles in different concentrations of polyvinyl alcohol （PVA） aqueous solution. The ablation of high pure silver plate in the solution is carried out by a nanosecond Q-switched Nd：YAG pulsed laser. X-ray diffraction and transmission electron microscopy are implemented to explore the particles sizes. The effects of PYA concentrations on the absorbance of the silver nanoparticles are studied as well, by using a UV-vis spectrophotometer. The preparation process is carried out for deionized water as a reference sample. The comparison of the obtained results with the reference sample shows that the formation efficiency of nanoparticles in PYA is much higher and the sizes of particles are also smaller.

关键词： silver nanoparticles