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Subchronic Oral Toxicity of silica Nanoparticles and silica microparticles in Rats

Biomedical and Environmental Sciences 2018年第3期31卷 197-207页

作者： LIANG Chun Lai XIANG Qian CUI Wen Ming FANG Jin SUN Na Na ZHANG Xiao Peng LI Yong Ning YANG Hui YU Zhou JIA Xu Dong Key Laboratory of Food Safety Assessment of Ministry of Health China National Center for Food Safety Risk Assessment Beijing 100021 China Sichuan Province Medical Science Academy & Sichuan Provincial People's Hospital Chengdu 610072 Sichuan China

Objective To investigate the subchronic oral toxicity of silica nanoparticles（NPs） and silica microparticles（MPs） in rats and to compare the difference in toxicity between two particle *** Sprague-Dawley rats were randomly divided into seven groups： the control group; the silica NPs low-, middle-, and high-dose groups; and the silica MPs low-, middle-, and high-dose groups [166.7,500, and 1,500 mg/（kg·bw·day）]. All rats were gavaged daily for 90 days, and deionized water was administered to the control group. Clinical observations were made daily, and body weights and food consumption were determined weekly. Blood samples were collected on day 91 for measurement of hematology and clinical biochemistry. Animals were euthanized for necropsy, and selected organs were weighed and fixed for histological examination. The tissue distribution of silicon in the blood, liver,kidneys, and testis were *** There were no toxicologically significant changes in mortality, clinical signs, body weight,food consumption, necropsy findings, and organ weights. Differences between the silica groups and the control group in some hematological and clinical biochemical values and histopathological findings were not considered treatment related. The tissue distribution of silicon was comparable across all *** Our study demonstrated that neither silica NPs nor silica MPs induced toxicological effects after subchronic oral exposure in rats.

关键词： Subchronic toxicity silica nanoparticles silica microparticles Rats

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