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A von-Neumann-like photonic processor and its application in studying quantum Signature of chaos

Light(Science & Applications) 2024年第4期13卷 672-681页

作者： Shang Yu Wei Liu Si-Jing Tao Zhi-Peng Li Yi-Tao Wang Zhi-Peng Zhong Raj BPatel Yu Meng Yuan-Ze Yang Zhao-An Wang Nai-Jie Guo Xiao-Dong Zeng Zhe Chen Liang Xu Ning Zhang Xiao Liu Mu Yang Wen-Hao Zhang Zong-Quan Zhou Jin-Shi Xu Jian-Shun Tang Yong-Jian Han Chuan-Feng Li Guang-Can Guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China. CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China. Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China. Research Center for Quantum Sensing Zhejiang LabHangzhou 310000China. Quantum Optics and Laser Science Blackett LaboratoryImperial College LondonPrince Consort RdLondon SW72AZUK. Clarendon Laboratory Department of PhysicsOxford UniversityParks Road OX13PUOxfordUK

Photonic quantum computation plays an important role and offers unique advantages.Two decades after the milestone work of Knill-Laflamme-Milburn,various architectures of photonic processors have been proposed,and quantum advantage over classical computers has also been demonstrated.It is now the opportune time to apply this technology to real-world applications.However,at current technology level,this aim is restricted by either programmability in bulk optics or loss in integrated optics for the existing architectures of processors,for which the resource cost is also a problem.Here we present a von-Neumann-like architecture based on temporal-mode encoding and looped structure on table,which is capable of multimode-universal programmability,resource-efficiency,phasestability and software-scalability.In order to illustrate these merits,we execute two different programs with varying resource requirements on the same processor,to investigate quantum Signature of chaos from two aspects:the Signature behaviors exhibited in phase space(13 modes),and the Fermi golden rule which has not been experimentally studied in quantitative way before(26 modes).The maximal program contains an optical interferometer network with 1694 freely-adjustable phases.Considering current state-of-the-art,our architecture stands as the most promising candidate for real-world applications.

关键词： quantum Signature chaos

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Signature of Superconductivity in Pressurized La_(4)Ni_(3)O_(10)

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Chinese Physics Letters 2024年第1期41卷 77-84页

作者：李庆张英杰项浙宁张宇航祝熙宇闻海虎 National Laboratory of Solid State Microstructures and Department of Physics Center for Superconducting Physics and MaterialsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

The discovery of high-temperature superconductivity near 80K in bilayer nickelate La_(3)Ni_(2)O_(7)under high pressures has renewed the exploration of superconducting nickelate in bulk materials.The extension of superconductivity in other nickelates in a broader family is also essential.Here,we report the experimental observation of superconducting Signature in trilayer nickelate La_(4)Ni_(3)O_(10)under high pressures.By using a modified solgel method and post-annealing treatment under high oxygen pressure,we successfully obtained polycrystalline La_(4)Ni_(3)O_(10)samples with different transport behaviors at ambient pressure.Then we performed high-pressure electrical resistance measurements on these samples in a diamond-anvil-cell apparatus.Surprisingly,the Signature of possible superconducting transition with a maximum transition temperature(T_(c))of about 20K under high pressures is observed,as evidenced by a clear drop of resistance and the suppression of resistance drops under magnetic fields.Although the resistance drop is sample-dependent and relatively small,it appears in all of our measured samples.We argue that the observed superconducting signal is most likely to originate from the main phase of La_(4)Ni_(3)O_(10).Our findings will motivate the exploration of superconductivity in a broader family of nickelates and shed light on the understanding of the underlying mechanisms of high-T_(c) superconductivity in nickelates.

关键词： materials superconductivity Signature

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Visually meaningful image encryption algorithm based on digital Signature

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Digital Communications and Networks 2023年第1期9卷 159-165页

作者： Xiaoling Huang Youxia Dong Guodong Ye Wun-She Yap Bok-Min Goi Faculty of Mathematics and Computer Science Guangdong Ocean UniversityZhanjiang524088China Lee Kong Chian Faculty of Engineering and Science Universiti Tunku Abdul RahmanJalan Sungai LongCheras43000SelangorMalaysia

Traditional image encryption algorithms transform a plain image into a noise-like image.To lower the chances for the encrypted image being detected by the attacker during the image transmission,a visually meaningful image encryption scheme is suggested to hide the encrypted image using another carrier image.This paper proposes a visually meaningful encrypted image algorithm that hides a secret image and a digital Signature which provides authenticity and confidentiality.The recovered digital Signature is used for the purpose of identity authentication while the secret image is encrypted to protect its confidentiality.Least Significant Bit(LSB)method to embed Signature on the encrypted image and Lifting Wavelet Transform(LWT)to generate a visually meaningful encrypted image are designed.The proposed algorithm has a keyspace of 139.5-bit,a Normalized Correlation(NC)value of 0.9998 which is closer to 1 and a Peak Signal to Noise Ratio(PSNR)with a value greater than 50 dB.Different analyses are also performed on the proposed algorithm using different images.The experimental results show that the proposed scheme is with high key sensitivity and strong robustness against pepper and salt attack and cropping attack.Moreover,the histogram analysis shows that the original carrier image and the final visual image are very similar.

关键词： Visually meaningful image encryption Lifting wavelet transform Lorenz system Signature Security

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Deciphering the transcriptomic Signature of synaptic activity

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Neural Regeneration Research 2022年第1期17卷 82-84页

作者： Guido Hermey Institute for Molecular and Cellular Cognition Center for Molecular Neurobiology HamburgUniversity Medical Center Hamburg-EppendorfHamburgGermany

Neurons undergo activity-dependent changes in their molecular composition and structure in order to regulate cellular processes such as dendritic growth,synapse elimination,spine maturation and synaptic strength.Such synaptic plasticity plays an important role during a critical period in brain development and contributes to sensory adaptation and to learning and memory in the mature nervous system.Its dysregulation underlies a number of pathological processes in psychiatric and neurodegenerative disorders,such as addiction.

关键词： strength. Signature elimination

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A serum microRNA Signature for enhanced selection of people for lung cancer screening

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Cancer Communications 2022年第11期42卷 1222-1225页

作者： Haixin Yu Janhavi R.Raut Megha Bhardwaj Yan Zhang Evelin Sandner Ben Schöttker Bernd Holleczek Petra Schrotz-King Hermann Brenner Division of Clinical Epidemiology and Aging Research German Cancer Research Center(DKFZ)Heidelberg 69120Baden-WürttembergGermany Medical Faculty Heidelberg University of HeidelbergHeidelberg 69120Baden-WürttembergGermany Division of Preventive Oncology German Cancer Research Center(DKFZ)and National Center for Tumor Diseases(NCT)Heidelberg 69120Baden-WürttembergGermany German Cancer Consortium(DKTK) German Cancer Research Center(DKFZ)Heidelberg 69120Baden-WürttembergGermany Pneumology and Thoracic Oncology Robert-Bosch KrankenhausKlinik SchillerhoeheGerlingen 70839Baden-WürttembergGermany Network Aging Research University of HeidelbergBergheimer Straße 20Heidelberg 69115Baden-WürttembergGermany Saarland Cancer Registry Präsident-Baltz-Straße 5Saarbrucken 66119SaarlandGermany

Dear editor,Lung cancer(LC)is the leading cause of cancer-related mortality globally[1].Earlier detection by screening can substantially reduce LC mortality[2,3],but should be focused on those at highest risk[4].Risk stratification for LC screening,which is mostly based on smoking history[5],is far from perfect[6].Therefore,additional criteria to better define those at highest risk of LC are needed to enhance the efficiency and cost-effectiveness of LC screening.Besides risk prediction models incorporating classical LC risk factors[7].

关键词： mortality cancer Signature

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Development of a prognostic Signature for esophageal cancer based on a novel 7-DNA damage repair genes Signature

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BIOCELL 2022年第12期46卷 2601-2613页

作者： JIAMING ZHAN WEIHUA WANG YANLEI TANG NING ZHOU DAOWEN JIANG Department of Thoracic Surgery Minhang HospitalFudan UniversityShanghai201199China

Esophageal cancer(EC)was an aggressive malignant neoplasm characterized by high morbidity and poor prognosis.Identifying the changes in DNA damage repair genes helps to better understand the mechanisms of carcinoma progression.In this study,by comparing EC samples and normal samples,we found a total of 132 DDR expression with a significant difference.Moreover,we revealed higher expression of POLN,PALB2,ATM,PER1,TOP3B and lower expression of HMGB1,UBE2B were correlated to longer OS in EC.In addition,a prognostic risk score based on 7 DDR gene expression(POLN,HMGB1,TOP3B,PER1,UBE2B,ATM,PALB2)was constructed for the prognosis of EC.Meanwhile,EC cancer samples were divided into 3 subtypes based on 132 DDR genes expressions.Clinical profile analysis showed cluster C1 and C2 showed a similar frequency of T2,which was remarked higher than that in cluster 3.Moreover,we found the immune cell inflation levels were significantly changed in different subtypes of EC.The infiltration levels of T cell CD8+,B cell and NK cells were greatly higher in cluster 2 than that in cluster 1 and cluster 3.The results showed T cell CD4+infiltration levels were dramatically higher in cluster 1 than that in cluster 2 and cluster 3.Finally,we perform bioinformatics analysis of DEGs among 3 subtypes of EC and found DDR genes may be related to multiple signaling,such as Base excision repair,Cell cycle,Hedgehog signaling pathway,and Glycolysis/Gluconeogenesis.These results showed DDR genes may serve as new target for the prognosis of EC and prediction of the potential response of immune therapy in EC.

关键词： Esophageal cancer DNA damage repair genes Signature Tumor immune infiltration

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Functional Striatal Abnormalities:A Distinct Brain Signature of Schizophrenia

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Neuroscience Bulletin 2021年第2期37卷 284-286页

作者： Sugai Liang Tao Li Mental Health Center and Psychiatric Laboratory State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China West China Brain Research Centre West China HospitalSichuan UniversityChengdu 610041China

Schizophrenia is a severe and complex mental disorder 111.Neuroimaging offers a powerful window for identifying the brain biomarkers and investigating the neuropathological mechanisms of psychiatric disorders.A study led by Professors Jiang and Liu,published recently in Nature Medicine,developed a new neuroimaging biomarker to characterize striatal dysfunction based on a multi-site functional MRI dataset with>1000 individuals.They show that this biomarker can distinguish individuals with schizophrenia and predict the short-term effects of antipsychotic treatmem[2].

关键词： individual Signature Schizophrenia

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Can metabolomic Signature foster precision medicine approaches in nonalcoholic fatty liver disease arena?

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Hepatobiliary Surgery and Nutrition 2022年第6期11卷 886-888页

作者： Amedeo Lonardo Azienda Ospedaliero-Universitaria ModenaItaly

Abnormal chemical reactions disrupting physiological bio-transformations in human body set the stage for the development of metabolic disorders(1).Clinically and epidemiologically,the metabolic syndrome is the most demanding among metabolic disorders in as much as it is globally common and exacts a major toll in terms of healthcare expenditures.

关键词： Signature globally foster

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Six-long non-coding RNA Signature predicts recurrence-free survival in hepatocellular carcinoma

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World Journal of Gastroenterology 2019年第2期25卷 220-232页

作者： Jing-Xian Gu Xing Zhang Run-Chen Miao Xiao-Hong Xiang Yu-Nong Fu Jing-Yao Zhang Chang Liu Kai Qu Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong University

BACKGROUND Recent evidence shows that long non-coding RNAs(lncRNAs) are closely related to hepatogenesis and a few aggressive features of hepatocellular carcinoma(HCC). Increasing studies demonstrate that lncRNAs are potential prognostic factors for HCC. Moreover, several studies reported the combination of lncRNAs for predicting the overall survival(OS) of HCC, but the results varied. Thus,more effort including more accurate statistical approaches is needed for exploring the prognostic value of lncRNAs in HCC.AIM To develop a robust lncRNA Signature associated with HCC recurrence to improve prognosis prediction of HCC.METHODS Univariate COX regression analysis was performed to screen the lncRNAs significantly associated with recurrence-free survival(RFS) of HCC in GSE76427 for the least absolute shrinkage and selection operator(LASSO) modelling. The established lncRNA Signature was validated and developed in The Cancer Genome Atlas(TCGA) series using Kaplan-Meier curves. The expression values of the identified lncRNAs were compared between the tumor and non-tumor tissues. Pathway enrichment of these lncRNAs was conducted based on the significantly co-expressed genes. A prognostic nomogram combining the lncRNA Signature and clinical characteristics was constructed.RESULTS The lncRNA Signature consisted of six lncRNAs: MSC-AS1, POLR2 J4, EIF3 J-AS1,SERHL, RMST, and PVT1. This risk model was significantly associated with the RFS of HCC in the TCGA cohort with a hazard ratio(HR) being 1.807(95%CI[confidence interval]: 1.329-2.457) and log-rank P-value being less than 0.001. The best candidates of the six-lncRNA Signature were younger male patients with HBV infection in relatively early tumor-stage and better physical condition but with higher preoperative alpha-fetoprotein. All the lncRNAs were significantly upregulated in tumor samples compared to non-tumor samples(P < 0.05). The most significantly enriched pathways of the lncRNAs were TGF-β signaling pathway, cellular apoptosis-associated pathways, etc. The nomogr

关键词： Long non-coding RNAs Hepatocellular carcinoma Prognostic Signature Recurrence-free survival Least absolute shrinkage and selection operator

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Weak-value amplification for the optical Signature of topological phase transitions

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Photonics Research 2020年第12期8卷 I0015-I0022页

作者： WEIJIE WU SHIZHEN CHEN WENHAO XU ZHENXING LIU RUNNAN LOU LIHUA SHEN HAILU LUO SHUANGCHUN WEN XIAOBO YIN Laboratory for Spin Photonics School of Physics and ElectronicsHunan UniversityChangsha 410082China Department of Mechanical Engineering University of ColoradoBoulderColorado 80309USA Materials Science and Engineering Program University of ColoradoBoulderColorado 80309USA

We show that weak measurements can be used to measure the tiny Signature of topological phase transitions.The Signature is an in-plane photonic spin Hall effect,which can be described as a consequence of a Berry phase.It is also parallel to the propagation direction of a light beam.The imaginary part of the weak value can be used to analyze ultrasmall longitudinal phase shifts in different topological phases.These optical Signatures are related to the Chern number and bandgaps;we also use a preselection and postselection technique on the spin state to enhance the original Signature.The weak amplification technique offers a potential way to determine the spin and valley properties of charge carriers,Chern numbers,and topological phases by direct optical measurement.

关键词： Signature topological transitions

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