检索结果-南通市图书馆

The global integrative network:integration of signaling and metabolic pathways

aBIOTECH 2022年第4期3卷 281-291页

作者： Yuying Lin Shen Yan Xiao Chang Xiaoquan Qi Xu Chi Department of Dermatology Xuan Wu HospitalBeijing100053China Agricultural Information Institute Chinese Academy of Agricultural ScienceBeijing100081China Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing100093China The Innovative Academy of Seed Design Chinese Academy of SciencesBeijing100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing100101China

The crosstalk between signaling and metabolic pathways has been known to play key roles in human diseases and plant biological processes.The integration of signaling and metabolic pathways can provide an essential reference framework for crosstalk analysis.However,current databases use distinct structures to present signaling and metabolic pathways,which leads to the chaos in the integrated networks.Moreover,for the metabolic pathways,the metabolic enzymes and the reactions are disconnected by the current widely accepted layout of edges and nodes,which hinders the topological analysis of the integrated networks.Here,we propose a novel“meta-pathway”structure,which uses the uniformed structure to display the signaling and metabolic pathways,and resolves the difficulty in linking the metabolic enzymes to the reactions topologically.We compiled a comprehensive collection of global integrative networks(GINs)by merging the meta-pathways of 7077 species.We demonstrated the assembly of the signaling and metabolic pathways using the GINs of four species—human,mouse,Arabidopsis,and rice.Almost all of the nodes were assembled into one major network for each of the four species,which provided opportunities for robust crosstalk and topological analysis,and knowledge graph construction.

关键词： Signaling pathways Metabolic pathways Integration Crosstalk of pathways

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signaling pathways of adipose stem cell-derived exosomes promoting muscle regeneration

引用

Chinese Medical Journal 2022年第21期135卷 2525-2534页

作者： Aoxuan Zhu Na Liu Yujia Shang Yonghuan Zhen Yang An Department of Plastic Surgery Peking University Third HospitalBeijing 100191China Department of Natural Products Chemistry School of Traditional Chinese Materia MedicaKey Laboratory of Structure-Based Drug Design and DiscoveryMinistry of EducationShenyang Pharmaceutical UniversityShenyangLiaoning 110016China

Severe muscle injury is still a challenging clinical problem. Exosomes derived from adipose stem cells (ASC-exos) may be a potential therapeutic tool, but their mechanism is not completely clear. This review aims to elaborate the possible mechanism of ASC-exos in muscle regeneration from the perspective of signal pathways and provide guidance for further study. Literature cited in this review was acquired through PubMed using keywords or medical subject headings, including adipose stem cells, exosomes, muscle regeneration, myogenic differentiation, myogenesis, wingless/integrated (Wnt), mitogen-activated protein kinases, phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/Akt), Janus kinase/signal transducers and activators of transcription, and their combinations. We obtained the related signal pathways from proteomics analysis of ASC-exos in the literature, and identified that ASC-exos make different contributions to multiple stages of skeletal muscle regeneration by those signal pathways.

关键词： Adipose stem cells Exosomes Muscle regeneration Signaling pathways

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

L.reuteri ZJ617 inhibits inflammatory and autophagy Signaling pathways in gut-liver axis in piglet induced by lipopolysaccharide

引用

Journal of Animal Science and Biotechnology 2022年第2期13卷 551-566页

作者： Tao Zhu Jiangdi Mao Yifan Zhong Congxiang Huang Zhaoxi Deng Yanjun Cui Jianxin Liu Haifeng Wang The Key Laboratory of Molecular Animal Nutrition Ministry of EducationCollege of Animal ScienceZhejiang UniversityHangzhou 310058China Xixi Hospital of Hangzhou Hangzhou 310023China

Background:This study investigated the protective effects of L.reuteri ZJ617 on intestinal and liver injury and the underlying mechanisms in modulating inflammatory,autophagy,and apoptosis Signaling pathways in a piglet challenged with lipopolysaccharide(LPS).Methods:Duroc×Landrace×Large White piglets were assigned to 3 groups(n=6/group):control(CON)and LPS groups received oral phosphate-buffered saline for 2 weeks before intraperitoneal injection(i.p.)of physiological saline or LPS(25μg/kg body weight),respectively,while the ZJ617+LPS group was orally inoculated with ZJ617 for 2 weeks before i.***.of LPS.Piglets were sacrificed 4 h after LPS injection to determine intestinal integrity,serum biochemical parameters,inflammatory signaling involved in molecular and liver injury pathways.Results:Compared with controls,LPS stimulation significantly increased intestinal phosphorylated-p38 MAPK,phosphorylated-ERK and JNK protein levels and decreased IκBαprotein expression,while serum LPS,TNF-α,and IL-6 concentrations(P<0.05)increased.ZJ617 pretreatment significantly countered the effects induced by LPS alone,with the exception of p-JNK protein levels.Compared with controls,LPS stimulation significantly increased LC3,Atg5,and Beclin-1 protein expression(P<0.05)but decreased ZO-1,claudin-3,and occludin protein expression(P<0.05)and increased serum DAO and D-xylose levels,effects that were all countered by ZJ617 pretreatment.LPS induced significantly higher hepatic LC3,Atg5,Beclin-1,SOD-2,and Bax protein expression(P<0.05)and lower hepatic total bile acid(TBA)levels(P<0.05)compared with controls.ZJ617 pretreatment significantly decreased hepatic Beclin-1,SOD2,and Bax protein expression(P<0.05)and showed a tendency to decrease hepatic TBA(P=0.0743)induced by LPS treatment.Pretreatment of ZJ617 before LPS injection induced the production of 5 significant metabolites in the intestinal contents:capric acid,isoleucine 1TMS,glycerol-1-phosphate byproduct,linoleic acid,alanine-alanine(P<0.05).Conclusions:These results demonstrated

关键词： Gut-liver axis Hepatic injury Intestinal barrier Lactobacillus Piglet Signaling pathways

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Signaling pathways governing the behaviors of leukemia stem cells

引用

Genes & Diseases 2024年第2期11卷 830-846页

作者： Shirin Azizidoost Ava Nasrolahi Mohadeseh Sheykhi-Sabzehpoush Amir Anbiyaiee Seyed Esmaeil Khoshnam Maryam Farzaneh Shahab Uddin Atherosclerosis Research Center Ahvaz Jundishapur University of Medical SciencesAhvaz ***Iran Infectious Ophthalmologic Research Center Ahvaz Jundishapur University of Medical SciencesAhvaz ***Iran Department of Laboratory Imam Khomeini Hospital ComplexTehran University of Medical SciencesTehran ***Iran Department of Surgery School of MedicineAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Persian Gulf Physiology Research Center Medical Basic Sciences Research InstituteAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Fertility Infertility and Perinatology Research CenterAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Translational Research Institute and Dermatology Institute Academic Health SystemHamad Medical CorporationDoha 3050Qatar

Leukemia is a malignancy in the blood that develops from the lymphatic system and bone marrow.Although various treatment options have been used for different types of leukemia,understanding the molecular pathways involved in the development and progression of leukemia is necessary.Recent studies showed that leukemia stem cells(LSCs)play essential roles in the pathogenesis of leukemia by targeting several Signaling pathways,including Notch,Wnt,Hedgehog,and STAT3.LSCs are highly proliferative cells that stimulate tumor initiation,migration,EMT,and drug resistance.This review summarizes cellular pathways that stimulate and prevent LSCs'self-renewal,metastasis,and tumorigenesis.

关键词： Leukemia Leukemia stem cells Pathogenesis Signaling pathways Stem cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signaling pathways in cancer-associated fibroblasts:recent advances and future perspectives

引用

Cancer Communications 2023年第1期43卷 3-41页

作者： Zengli Fang Qingcai Meng Jin Xu Wei Wang Bo Zhang Jiang Liu Chen Liang Jie Hua Yingjun Zhao Xianjun Yu Si Shi Department of Pancreatic Surgery Fudan University Shanghai Cancer CenterShanghai 200032P.R.China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China Shanghai Pancreatic Cancer Institute Shanghai 200032P.R.China Pancreatic Cancer Institute Fudan UniversityShanghai 200032P.R.China Institutes of Biomedical Sciences Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China

As a critical component of the tumor microenvironment(TME),cancerassociated fibroblasts(CAFs)play important roles in cancer initiation and progression.Well-known Signaling pathways,including the transforming growth factor-β(TGF-β),Hedgehog(Hh),Notch,Wnt,Hippo,nuclear factor kappa-B(NF-κB),Janus kinase(JAK)/signal transducer and activator of transcription(STAT),mitogen-activated protein kinase(MAPK),and phosphoinositide 3-kinase(PI3K)/AKT pathways,as well as transcription factors,including hypoxia-inducible factor(HIF),heat shock transcription factor 1(HSF1),P53,Snail,and Twist,constitute complex regulatory networks in theTMEtomodulate the formation,activation,heterogeneity,metabolic characteristics and malignant phenotype of CAFs.Activated CAFs remodel the TME and influence the malignant biological processes of cancer cells by altering the transcriptional and secretory characteristics,and this modulation partially depends on the regulation of signaling cascades.The results of preclinical and clinical trials indicated that therapies targeting Signaling pathways in CAFs demonstrated promising efficacy but were also accompanied by some failures(e.g.,NCT01130142 and NCT01064622).Hence,a comprehensive understanding of the signaling cascades in CAFs might help us better understand the roles of CAFs and the TME in cancer progression and may facilitate the development of more efficient and safer stroma-targeted cancer therapies.Here,we review recent advances in studies of Signaling pathways in CAFs and briefly discuss some future perspectives on CAF research.

关键词： Signaling pathways Cancer-associated fibroblasts Cell-cell interaction Tumor microenvironment Therapeutic targets

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regulation of Signaling pathways in hair follicle stem cells

引用

Burns & Trauma 2022年第1期10卷 306-324页

作者： Xiaoxiang Wang Yinghui Liu Jia He Jingru Wang Xiaodong Chen Ronghua Yang Department of Burn Surgery The First People’s Hospital of FoshanFoshan 528000China Guangdong Medical University Zhanjiang524000China Department of Dermatology Dermatology HospitalSouthern Medical UniversityGuangzhou510091China

Hair follicle stem cells(HFSCs)reside in the bulge region of the outer root sheath of the hair follicle.They are considered slow-cycling cells that are endowed with multilineage differentiation potential and superior proliferative capacity.The normal morphology and periodic growth of HFSCs play a significant role in normal skin functions,wound repair and skin regeneration.The HFSCs involved in these pathophysiological processes are regulated by a series of cell signal transduction pathways,such as lymphoid enhancer factor/T-cell factor,Wnt/β-catenin,transforming growth factor-β/bone morphogenetic protein,Notch and Hedgehog.The mechanisms of the interactions among these Signaling pathways and their regulatory effects on HFSCs have been previously studied,but many mechanisms are still unclear.This article reviews the regulation of hair follicles,HFSCs and related Signaling pathways,with the aims of summarizing previous research results,revealing the regulatory mechanisms of HFSC proliferation and differentiation and providing important references and new ideas for treating clinical diseases.

关键词： Hair follicle stem cells Signaling pathways Proliferation Differentiation Regenerative Repair

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signaling pathways downstream to receptor tyrosine kinases:targets for cancer treatment

引用

Journal of Cancer Metastasis and Treatment 2020年第1期6卷 556-574页

作者： Emma Cordover Audrey Minden Susan Lehman Cullman Laboratory for Cancer Research Department of Chemical BiologyErnest Mario School of PharmacyRutgersThe State University of New JerseyPiscatawayNJ 08854USA

Mammalian cells have the ability to respond to a myriad of diverse extracellular stimuli that modulate cell function.This often involves ligands binding to cell surface receptors and subsequent activation of intracellular Signaling pathways.These pathways can lead to changes in gene expression patterns that in turn regulate cell growth,differentiation,migration,and function.One important type of cell surface receptor is the receptor tyrosine kinase(RTK).In response to in response to ligand binding,RTKs dimerize,then trans-phosphorylate each other,leading to activation of downstream pathways.While the signaling proteins in these pathways are important for normal cell growth control,when improperly regulated they can lead to uncontrolled growth and sometimes cancer.For this reason,they are often considered to be good candidates for drug targets for chemotherapeutic drugs.RTKs can activate multiple different Signaling pathways.Some of the signaling proteins in these pathways can have crosstalk with other RTK activated pathways,and some of them can be activated by multiple mechanisms in addition to activation by RTKs.While there is a wide array of different signaling proteins and pathways activated by RTKs,in this review we will discuss components of several key pathways including the MAPK pathway,the Her2/Neu pathway,mTOR,and Pak kinases.We provide an overview of the roles for these pathways in cell signaling and discuss how different components of these pathways are being considered as targets for cancer treatment.

关键词： Receptor tyrosine kinases Signaling pathways targeted cancer therapeutics oncogenes cell signaling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Auricularia polytricha and Flammulina velutipes ameliorate inflammation and modulate the gut microbiota via regulation of NF-κB and Keap1/Nrf2 Signaling pathways on DSS-induced inflammatory bowel disease

引用

Food Bioscience 2022年第3期47卷 356-370页

作者： Ivan Stève Nguepi Tsopmejio Miao Ding Jiali Wei Cong Zhao Yu Jiang Yuting Li Hui Song School of Life Science Jilin Agricultural UniversityJilinPR China Department of Animal Biology and Physiology University of Yaoundé ICameroon Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi ChangchunPR China

Flammulina velutipes and Auricularia polytricha are two popular dietary mushrooms,especially in the Northeast of China.They have revealed many pharmacological effects due to their bioactive compounds,but their possible mechanism of action involved in inflammation remains poorly known.Therefore,Inflammatory bowel disease(IBD)which is a chronic disease and progressive inflammation in the gastrointestinal tract were used to evaluate their anti-inflammatory and modulatory properties on the intestinal microbiota via the Signaling pathways involved by oral administration of F.velutipes(FVE)and A.polytricha(APE).Mice were daily received 3%DSS in the drinking water followed by the daily administration of FVE and APE.The food consumption,weight variation and DAI score were assessed during the experiment and inflammatory parameters,mRNA and protein expressions to determine the possible Signaling pathways involved,and the gut microbiota from the cecum by high-throughput sequencing.Data showed that APE and FVE improved clinical symptoms,inflammatory cytokines and oxidative markers.They also attenuated the mRNA and proteins expressions in colon tissue.Moreover,APE and FVE regulated DSS-induced intestinal dysbiosis and stimulated the SCFAs production.Overall,APE and FVE could improve DSS-induced IBD in mice suggesting that they represent novels therapeutic drugs and could be used as prebiotic to modulate the gut microbiota and preserve intestinal integrity.

关键词： Flammulina velutipes Auricularia polytricha Inflammatory bowel disease Signaling pathways Intestinal microbiota

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

TP53BP2:Roles in suppressing tumorigenesis and therapeutic opportunities

引用

Genes & Diseases 2023年第5期10卷 1982-1993页

作者： Yunfei Huo Ke Cao Buxin Kou Mengyin Chai Shuangshuang Dou Dexi Chen Ying Shi Xiaoni Liu Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China

Malignant tumor is still a major problem worldwide.During tumorigenesis or tumor development,tumor suppressor p53-binding protein 2(TP53BP2),also known as apoptosis stimulating protein 2 of p53(ASPP2),plays a critical role in p53 dependent and independent manner.Expression of TP53BP2 is highly correlated with the prognosis and survival rate of malignant tumor patients.TP53BP2 can interact with p53,NF-κB p65,Bcl-2,HCV core protein,PP1,YAP,CagA,RAS,PAR3,and other proteins to regulate cell function.Moreover,TP53BP2 can also regulate the proliferation,apoptosis,autophagy,migration,EMT and drug resistance of tumor cells through downstream Signaling pathways,such as NF-κB,RAS/MAPK,mevalonate,TGF-β1,PI3K/AKT,aPKC-ι/GLI1 and autophagy pathways.As a potential therapeutic target,TP53BP2 has been attracted more attention.We review the role of TP53BP2 in tumorigenesis or tumor development and the signal pathway involved in TP53BP2,which may provide more deep insight and strategies for tumor treatment.

关键词： Binding proteins Signaling pathways TP53 TP53BP2 Tumorigenesis Tumor development

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Emodin Ameliorates High Glucose-Induced Podocyte Apoptosis via Regulating AMPK/mTOR-Mediated Autophagy signaling Pathway

引用

Chinese Journal of Integrative Medicine 2023年第9期29卷 801-808页

作者： LIU Hong CHEN Wei-dong HU Yang-lin YANG Wen-qiang HU Tao-tao WANG Huan-lan ZHANG Yan-min Department of Nephrology Wuhan No.1 HospitalWuhan430022China Department of Central Laboratory Wuhan No.1 HospitalWuhan430022China

Objective To investigate the effect of emodin on high glucose(HG)-induced podocyte apoptosis and whether the potential anti-apoptotic mechanism of emodin is related to induction of adenosine-monophosphate-activated protein kinase(AMPK)/mammalian target of rapamycin(mTOR)-mediated autophagy in podocytes(MPC5 cells)in vitro.Methods MPC5 cells were treated with different concentrations of HG(2.5,5,10,20,40,80 and 160 mmol/L),emodin(2,4,8µmol/L),or HG(40 mmol/L)and emodin(4µmol/L)with or without rapamycin(Rap,100 nmol/L)and compound C(10µmol/L).The viability and apoptosis of MPC5 cells were detected using cell counting kit-8(CCK-8)assay and flow cytometry analysis,respectively.The expression levels of cleaved caspase-3,autophagy marker light chain 3(LC3)Ⅰ/Ⅱ,and AMPK/mTOR signaling pathway-related proteins were determined by Western blot.The changes of morphology and RFP-LC3 fluorescence were observed under microscopy.Results HG at 20,40,80 and 160 mmol/L dose-dependently induced cell apoptosis in MPC5 cells,whereas emodin(4µmol/L)significantly ameliorated HG-induced cell apoptosis and caspase-3 cleavage(Psignaling pathway,which might provide a potential therapeutic option for diabetic nephropathy.

关键词： emodin diabetic nephropathy autophagy podocyte apoptosis adenosine-monophosphate-activated protein kinase/mammalian target of rapamycin Signaling pathways

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：