检索结果-南通市图书馆

Performance of sickle scan<sup>®</sup>in the Screening of sickle Cell Disease in Kisangani Pregnant Women and Attitude towards Results

引用

Open Journal of Blood Diseases 2020年第2期10卷 23-36页

作者： Yvette Neema-Ufoy Mungu Jean Jeannot Juakali-Sihalikyolo Roland Djang’eing’a Marini Gédéon Katenga-Bosunga Hermane Avohou-Tonakpon Stéphane Leduc Franç ois Boemer Salomon Batina-Agasa Department of Obstetrics and Gynecology Kisangani University Clinics University of Kisangani Kisangani The Democratic Republic of the Congo Department of Pharmaceutical Sciences Faculty of Medicine and of Pharmacy Kisangani The Democratic Republic of the Congo Laboratory of Pharmaceutical and Analytical Chemistry Department of Pharmacy CIRM University of Liege Liege Belgium Laboratory of Biochemistry and Human Genetics University Hospital of Liege Liege Belgium Department of Internal Medicine Kisangani University Clinics Kisangani The Democratic Republic of the Congo

In the Democratic Republic of the Congo, the sickle cell trait carriage is estimated at 25%. Routine neonatal screening is not a common practice, leading to a very late diagnosis. In this study, the screening of pregnant women was assessed as well as their attitudes. This is an analytical cross-sectional study conducted in 245 pregnant women, sampled by convenience in four hospitals in Kisangani city (Democratic Republic of Congo) and screened using the sickle scan® test, from February 1 to July 31, 2019. The sensitivity and specificity of the latter were determined using liquid chromatography coupled with mass spectrometry as the gold standard. The attitudes of 240 pregnant women without previous screening history were assessed upon the announcement of the results. The sensitivity of screening for hemoglobin (Hb) AA and Hb AS was 96.69% and 98.39%, respectively;while the specificities were 99.43% and 96.32%, respectively. The Kappa coefficient (κ) was excellent. Concerning attitudes, Hb SS pregnant women and 55.17% of AS pregnant women worried when the results relating to their hemoglobin status were announced. The sickle scan® test was found reliable for sickle cell disease screening in Kisangani. The announcement of the results, mainly positive, raises worry among pregnant woman. Therefore, we recommend the involvement of a clinician psychologist for pre-screening counselling and for results announcement, as well as early newborns and unmarried teenage girls screening.

关键词： sickle scan® Liquid Chromatography Pregnant Women Attitudes Kisangani

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：