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Effects of Multiple Cleaning and Disinfection Interventions on Infectious Diseases in Children: A Group Randomized Trial in China

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Biomedical and Environmental Sciences 2015年第11期28卷 779-787页

作者： BAN Hai Qun LI Tao SHEN Jin LI Jin PENG Pin Zhang YE Heng Ping ZHANG Liu Bo Institute of Environment Health and Related Product Safety Center for Disease Control and Prevention of China Center for Disease Control and Prevention of Xiantao city

Objective To assess the effectiveness of multiple cleaning and disinfection interventions in the homes and kindergartens, in reducing gastrointestinal and respiratory illnesses of children. Methods From October 2010 to September 2011, we performed a prospective, controlled study in China. 408 children under 5 years old were recruited and group randomized into intervention and control groups. Families and kindergartens in the intervention group were provided with antibacterial products for hand hygiene and surface cleaning or disinfection for one year. Each child＇s illness symptoms and sick leave were recorded every day. Results A total of 393 children completed the study, with similar baseline demographics in each of the 2 groups. Except for abdominal pain, the odds of symptoms （fever, cough and expectoration, runny nose and nasal congestion, diarrhea）, illness （acute respiratory illness and gastrointestinal illness）, and sick leave per person each month were significantly reduced by interventions. The rates of fever, diarrhea, acute respiratory illness, gastrointestinal illness and sick leave per person per year were significantly decreased as well. Conclusion Not only the acute respiratory children were significantly reduced by multiple and gastrointestinal illness but the sick leave rate in interventions.

关键词： Communicable disease control Child daycare centers sick leave Antibacterial agents Hand hygiene Domestic hygiene Surface cleaning Surface disinfection

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Gastro esophageal reflux disease is associated with absence from work: Results from a prospective cohort study

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World Journal of Gastroenterology 2005年第45期11卷 7148-7151页

作者： Andreas Leodolter Marc Nocon Michael Kulig Stefan N Willich Peter Malfertheiner Joachim Labenz Department of Gastroenterology Institute of Social Medicine Ev.Jung-Stilling-Krankenhaus

AIM： To study the association of gastro-esophageal reflux disease （GERD） with the absence from work and to estimate the extent of loss in gross domestic product due to inability to work. METHODS： Analysis was based on the prospectively gathered data of a large European cohort study involving 6 215 symptomatic GERD patients （ProGERD）. Among these patients, 2 871 were initially employed. The calculation of the loss of gross domestic product was based on the assumption that the prevalence of GERD was about 15% in Germany. According to the German Federal Statistical Office, the mean gross wage of employees was 150 E/d in 2002. RESULTS： The data of 2 078 employed patients who were prospectively followed up for over 2 years were analyzed. At study entry, the patients reported a mean of 1.8 d per year of inability to work. During the prospective follow-up under routine clinical care, the proportion of patients reporting days with inability to work decreased from 14% to 6% and the mean number of days per year with inability to work decreased to 0.9 d. Assuming a prevalence of troublesome GERD of 15% in the employed German population, the loss of gross domestic product amounted to 668 million E/year in Germany. CONCLUSION： GERD causes a relevant impairment on the national economics by absence from work. The presented data demonstrate the importance of GERD, not only for patients and health insurance companies, but also for the community at large.

关键词： Gastro-esophageal reflux sick leave Medicale conomics

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