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Metabonomics delineates allergic reactions induced by shuang-huang-lian injection in rats using ultra performance liquid chromatography-mass spectrometry

引用

Chinese Journal of Natural Medicines 2018年第8期16卷 628-640页

作者： GU Yuan-Yuan SHI Lang ZHANG Dan-Dan huang Xin CHEN Da-Zhong Research Institute of Traditional Chinese Medicine Heilongjiang University of Chinese Medicine First Clinical Medical College Heilongjiang University of Chinese Medicine

shuang-huang-lian Injection(SHLI) is the first successfully developed drug from traditional Chinese medicine(TCM) powder for injection,since its use for the treatment of acute respiratory tract infection,pneumonia,influenza,*** the same time,its allergic reactions have also emerged,which limits clinical ***,few scholars pay attention to the mechanism of allergic *** this present study,metabonomics technology was used to explore the changes in endogenous metabolites in urine of the rat model of SHLI induced allergic reaction;we and analyzed the metabolites,metabolic pathway,and the mechanism which were closely related to the allergic *** levels of serum histamine and tryptase were examined and changes in histomorphology were also *** on the UPLC-Q-TOF/MS metabonomics,we carried out the pattern recognition analysis,selected potential biomarkers associated with allergic reactions,and explored the pathological mechanism for SHLI induced allergic reaction,which laid the foundation for the safety research of *** results showed that SHLI increased the levels of serum histamine and tryptase in rats with allergic reaction;we determined 15 biomarkers in rat allergic reaction model induced by SHLI and found multiple metabolic pathways involved,such as metabolism of linolenic acid,phenylalanine,amino acid,2-oxo acid,and purine and other metabolic pathways.

关键词： shuang-huang-lian injection Biomarker Metabonomics Allergic mechanism Metabolites

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Population pharmacokinetic analysis of baicalin after oral administration of different shuang-huang-lian formulations to rats

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Journal of Chinese Pharmaceutical Sciences 2008年第1期17卷 46-54页

作者：张关敏陈文倩李良胡渝慧张彦青易红杨华卢炜北京大学药学院药剂学系北京100083 中国中医科学院中药研究所北京100700

To investigate pharmacokinetics ofbaicalin after an oral administration of different shuang-huang-lian （SHL） formulations to rats. Different SIlL formulations were orally administered to rats. The concentrations of baicalin in rat plasma were determined by HPLC, the non-compartmental pharmacokinetic parameters and population pharmacokinetic parameters of baicalin were estimated by WinNonlin and NONMEM. The plasma concentration profiles of baicalin demonstrated double-peak phenomenon except for group microemulsion prescription 2. Population pharmacokinetic model developed includes four covariates, which were the effect of formulation （FORM） on CL/F and V/F, the effect of body weight （BW） on Ka, and the effect of gender （GEND） on V/F. Numbers 1 to 6 denote SHL formulation decoction, oral liquid, colloidal solution, microemulsion prescription 1, microemulsion prescription 2 and granule, respectively. The equations for the parameters are as following： CL/F = （0.432 ＋ 0.529）. e^ηCl L/h if formulation was 2 or 6, otherwise CL/F = 0.432. e^ηCl L/h ; V/F = （11.3- 4.03 - 3.87. GEND）. e^ηv L if formulation was 5, otherwise V/F = （11.3 - 3.87. GEND）. e^ηv L ; Ka = 0.475. [1 - 0.0223. （BW - 195.1）]. e^ηKah^-1. SHL formulations have significant effects on the nharmacokinefic narameters.

关键词： Baicalin Population pharmacokinetics Enterohepatic recirculation shuang-huang-lian

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