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Effect of Naloxone on Microcirculation During Irreversible hemorrhagic shock

Journal of Medical Colleges of PLA 1986年第1期 31-37页

作者：赵克森朱佐江吴坤莹黄绪亮 Department of Pathophysiology First Military Medical College Guangzhou

Thirty-six male Sprague-Dawley rats were used and divided into 3 groups(N=12):simple hemorrhagic shock group,salinetreated group,and naloxone-treated group.A new method by synchronous video tape recording with 2cameras simple was established to observe the relationship between the changeof blood pressure and that of microcirculation of cremaster *** wasshown that the plugging of WBC in capillaries might be the reason for noreflow in microvessels after transfusion and infusion during irreversibleshock *** of naloxone followed by reinfusion of the shedblood increased blood pressure and pulse *** the increase of pulsepressure a pulsed blood flow rushed the stationary of blood cells in capil-laries,which eventually pushed them away and led to reperfusion in *** made blood pressure and velocity of blood flow increase *** 24-hour survival rate was significantly increased in naloxone-treated group(10/12),as compared with that in saline-treated group(1/12).The mechanism of naloxone treatment was *** was suggested thatthe effects of cardiac and microcirculatory event may influence each other,which plays an important role in the pathogenesis of irreversible hemorrhagicshock.

关键词： shock,hemorrhagic blood pressure naloxone microcirculation disease model,aminal cremaster muscle

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Effects of CO2 pneumoperitoneum on blood flow vol-ume of abdominal organs of rabbits with controlled hem-orrhagic shock and liver impact injuries

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Chinese Journal of Traumatology 2009年第1期12卷 -页

作者： Lian-yang ZHANG[a] Song ZHAO[a] Yong LI[a] Xiao-lin MA[a] Department of Traumatic Surgery Research Institute of Surgery/Daping Hospital Third Military Medical UniversityChongqing 400042 China

Objective: To investigate the effects of CO2 pneumo-peritoneum on blood flow volume of abdominal organs of rabbits with controlled hemorrhagic shock model and liver impact ***: After controlled hemorrhagic shock and liver impact injuries, the rabbit model was established. Eighteen rabbits subjected to hemorrhagic shock and liver impact inju-ries were divided into 3 groups randomly according to the volume of lost blood: light hemorrhagic shock (blood loss volume was 10%, 6 ml/kg), moderate hemorrhagic shock (20%, 12 ml/kg) and severe hemorrhagic shock (40%, 22 ml/kg). Intraabdominal pressures of CO2 pneumoperitoneum was 10 mmHg. Color-labeled microspheres were used to mea-sure the blood flow volume of the liver, kidney and stomach before pneumoperitoneum at 30 minutes and 2 hours after pneumoperitoneum and 30 minutes after deflation. And the mortality and hepatic traumatic condition of rabbits were ***: Of the 18 rabbits, there were 9 with liver impact injuries at Grade Ⅰ, 8 at Grade Ⅱ and Ⅰ at Grade Ⅲ (according to AIS-2005). The mortality rate in light hemorrhagic shock group was 33.33%, and that in moderate or severe hemor-rhagic shock group was 100% within 30 minutes and 2 hours after pneumoperitoneum, respectively. The blood flow vol-ume in the organs detected decreased at 30 minutes under pneumoperitoneum in light and moderate hemorrhagic shock groups. At the same time, the blood flow volume of the liver in moderate hemorrhagic shock group decreased more sig-nificantly than that in light hemorrhagic shock ***: The blood flow volume of abdominal organs in rabbits is decreased obviously under CO2 pneumoperitoneum, with fairly high mortality rate. It is be-lieved that CO2 pneumoperitoneum should cautiously be used in abdominal injury accompanied with hemorrhagic shock, especially under non-resuscitation conditions.

关键词： Abdominal injuries shock,hemorrhagic Pneumoperitoneum,artificial Regional blood flow

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