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shizhenqing granule stimulates the hypothalamic-pituitary-adrenal axis and reduces serum pro-inflammatory factors in a rat model with chronic eczema

引用

Journal of Traditional Chinese Medical Sciences 2020年第4期7卷 386-392页

作者： Jinrui Lu Xiaoyan Liu Yao Xiao Shuran Ma Department of Pharmacy Qiannan Medical College for NationalitiesDuyun558013China College of Traditional Chinese Medicine Yunnan University of Chinese MedicineKunming650500China Ward Two Department of NephroendocrinologyDongzhimen Hospital Beijing University of Chinese MedicineBeijing100700China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China

Objective:In this study,we examined the effects of shizhenqing granule(SZQG)on hypothalamicpituitary-adrenal(HPA)axis and serum inflammatory factors in a rat model of chronic eczema,in order to explore the mechanism of action of SZQG in treatment of this ***:Sixty SpragueeDawley male rats were randomly divided into six groups(with 10 rats per group):blank group;model group;positive control group(prednisone);and the low-,medium-,and high-dose SZQG *** for the blank group,rats in all other groups were treated with 2,4-dinitrochlorobenzene to induce chronic *** rats were administered prednisone or SZQG for 7 consecutive days after successful establishment of the chronic eczema model,and samples were collected 12 h after the last *** degree of skin lesions and the changes in serum levels of corticotropin-releasing hormone(CRH),adrenocorticotropic hormone(ACTH),cortisol(CORT),interleukin(IL)-4,interferon(IFN)-g,IL-25,and IL-31 among the groups were ***:SZQG effectively increased the levels of CRH,ACTH,and CORT,which decreased in the serum of rats with chronic eczema,stimulated the function of the HPA axis,and promoted the expression of *** reduced the serum levels of inflammatory factors including IL-4,IL-25 and IL-31,which were overexpressed in rats with chronic eczema,and increased those of anti-inflammatory factor IFN-g,thereby alleviating the inflammatory symptoms and itching,and ameliorating the clinical symptoms of chronic ***:SZQG effectively alleviates skin lesions in the chronic eczema rat model by stimulating the function of the HPA axis.

关键词： shizhenqing granule Chronic eczema Hypothalamic-pituitary-adrenal axis Inflammatory factors

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