检索结果-南通市图书馆

Integrated UHPLC-MS and network pharmacology to explore the active constituents and pharmacological mechanisms of shenzao dripping pills against coronary heart disease

引用

Traditional Medicine Research 2022年第3期7卷 68-80页

作者： Tao Hu Ke-Ning Zheng Jia-Yin Liang Dan Tang Lu-Yong Zhang Ming-Hua Xian Shu-Mei Wang Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of Traditional Chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province Guangzhou 510006China School of Traditional Chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems Guangdong Pharmaceutical UniversityGuangzhou 510006China School of Pharmacy Guangdong Pharmaceutical UniversityGuangzhou 510006China

Background:shenzao dripping pills(SZDP)is an empirical prescription of traditional Chinese medicine that is mainly used to treat coronary heart ***,the chemical composition and pharmacological mechanisms of SZDP are ***:In this study,ultra-high performance liquid chromatography-quadruple-Exactive Orbitrap mass spectrometry was used to identify the chemical components in extracts and medicated plasma of ***,we performed network pharmacology methods,including target prediction by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine,protein-protein interaction network via STRING database;further,the key targets and compounds were screened using ***,the key targets and compounds were validated by molecular ***:72 chemical constituents were identified from SZDP by high performance liquid chromatography and mass spectrometry *** the components absorbed into plasma by SZDP,24 prototype components and 9 metabolized components were *** network pharmacology analysis of the prototype components showed that there are 13 key compounds(including ginsenoside Rc,Rb1,Rb2,ferulic acid,etc.),90 proteins(including proto-oncogene tyrosine-protein kinase Src,nuclear receptor subfamily 3 group C member 1,caspase-3,etc.),and 10 pathways(including estrogen,IL-17 and VEGF signaling pathway,etc.)that play an essential role in the treatment of coronary heart disease with *** addition,the results of molecular docking revealed that ginsenosides Rc,Rb2 and Rb1 have strong binding activities to the caspase-3,as well as ginsenoside Rb2 to the nuclear receptor subfamily 3 group C member ***:This study showed that SZDP might act through multiple chemical constituents and targets against coronary heart disease.

关键词： shenzao dripping pills coronary heart disease chemical constituents network pharmacology molecular docking

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：